Strain Name:
C57BL/6J-MtgxR0313Btlr/Mmmh
Stock Number:
038523-MU
Citation ID:
RRID:MMRRC_038523-MU
Other Names:
R0313 (G1), C57BL/6J-MtgxR0313Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Ppp1r37
Name: protein phosphatase 1, regulatory subunit 37
Synonyms: Lrrc68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232947
Homologene: 17851
Pcif1
Name: phosphorylated CTD interacting factor 1
Synonyms: 2310022K11Rik, F730014I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228866
Homologene: 11134
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4631402N15Rik, 4833420O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74841
Homologene: 12367
Prmt1
Name: protein arginine N-methyltransferase 1
Synonyms: 6720434D09Rik, Hrmt1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15469
HGNC: HGNC:5187
Homologene: 21477
Fbxl17
Name: F-box and leucine-rich repeat protein 17
Synonyms: Fbx13, C130023C01Rik, 6330576B01Rik, Fbxo13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50758
Homologene: 79859
Esyt2
Name: extended synaptotagmin-like protein 2
Synonyms: 2410017M09Rik, 4921504I16Rik, 2310058N22Rik, D12Ertd551e, Fam62b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 52635
VEGA: 12
Homologene: 32699
Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Synonyms: Bcrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26357
HGNC: HGNC:74
Homologene: 55852
Wdr12
Name: WD repeat domain 12
Synonyms: Ytm1, Ytm1p, 4933402C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57750
Homologene: 10098
Ska2
Name: spindle and kinetochore associated complex subunit 2
Synonyms: 1110001A07Rik, Fam33a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66140
Homologene: 11926
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230249
Homologene: 6056
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 6430549P11Rik, 2310047C04Rik, 2A-HUB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224170
Homologene: 8771
Cldn18
Name: claudin 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56492
HGNC: HGNC:2039
Homologene: 9489
Slc39a7
Name: solute carrier family 39 (zinc transporter), member 7
Synonyms: Ke-4, H-2Ke4, KE4, Ring5, H2-Ke4, Zip7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14977
HGNC: HGNC:4927
Homologene: 5072
Rasa1
Name: RAS p21 protein activator 1
Synonyms: p120-rasGAP, Gap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218397
HGNC: HGNC:9871
Homologene: 2168
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Xylt2
Name: xylosyltransferase II
Synonyms: E030002B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217119
Homologene: 23349
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5c, Nav1.5, mH1, SkM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20271
Homologene: 22738
Haspin
Name: histone H3 associated protein kinase
Synonyms: Gsg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14841
Homologene: 49236
Vmn2r5
Name: vomeronasal 2, receptor 5
Synonyms: EG667060
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 667060
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329421
Homologene: 51393
Stox2
Name: storkhead box 2
Synonyms: 4933409N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71069
Homologene: 18414
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Ncf1
Name: neutrophil cytosolic factor 1
Synonyms: p47phox, NADPH oxidase subunit (47kDa), Ncf-1, NOXO2, p47phox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17969
HGNC: HGNC:7660
Homologene: 30964
Tcam1
Name: testicular cell adhesion molecule 1
Synonyms: 4930570F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75870
Homologene: 123944
Lcp1
Name: lymphocyte cytosolic protein 1
Synonyms: L-fimbrin, Pls2, D14Ertd310e, L-plastin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18826
HGNC: HGNC:6528
Homologene: 80174
Mcmdc2
Name: minichromosome maintenance domain containing 2
Synonyms: 6030422M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240697
Homologene: 18309
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241158
Homologene: 9561
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319876
Homologene: 8933
Ssrp1
Name: structure specific recognition protein 1
Synonyms: T160, Hmgi-rs3, Hmg1-rs1, Hmgox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20833
Homologene: 110735
Olfr1297
Name: olfactory receptor 1297
Synonyms: GA_x6K02T2Q125-72673494-72672556, MOR248-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258890
Homologene: 115545
Ebf4
Name: early B cell factor 4
Synonyms: Olf-1/EBF-like 4, O/E-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228598
Homologene: 65064
Cc2d1a
Name: coiled-coil and C2 domain containing 1A
Synonyms: Freud-1, Tape
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212139
Homologene: 23040
Olfr250
Name: olfactory receptor 250
Synonyms: GA_x6K02T2MYUG-19447-18473, MOR170-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404312
VEGA: 9
Homologene: 74151
Uqcrc1
Name: ubiquinol-cytochrome c reductase core protein 1
Synonyms: 1110032G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22273
Homologene: 2525
Ltv1
Name: LTV1 ribosome biogenesis factor
Synonyms: 2610020N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 353258
VEGA: 10
Homologene: 6338
Olfr765
Name: olfactory receptor 765
Synonyms: GA_x6K02T2PULF-10732607-10731678, MOR115-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 544748
Homologene: 105186
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 9,932,141 bp
  • A to G, chromosome 1 at 46,207,643 bp
  • A to T, chromosome 1 at 60,082,579 bp
  • C to T, chromosome 1 at 92,886,221 bp
  • G to A, chromosome 2 at 65,095,744 bp
  • T to A, chromosome 2 at 70,348,959 bp
  • T to A, chromosome 2 at 85,041,554 bp
  • C to T, chromosome 2 at 111,621,600 bp
  • T to C, chromosome 2 at 130,306,787 bp
  • A to T, chromosome 2 at 164,884,419 bp
  • T to A, chromosome 3 at 64,503,827 bp
  • A to G, chromosome 4 at 58,811,892 bp
  • T to C, chromosome 5 at 14,678,873 bp
  • T to C, chromosome 5 at 25,344,930 bp
  • T to C, chromosome 5 at 134,229,567 bp
  • A to G, chromosome 6 at 58,672,097 bp
  • G to A, chromosome 7 at 19,533,998 bp
  • T to C, chromosome 7 at 44,978,748 bp
  • C to T, chromosome 8 at 47,192,134 bp
  • A to T, chromosome 8 at 80,984,442 bp
  • G to A, chromosome 8 at 84,136,969 bp
  • T to C, chromosome 9 at 38,368,304 bp
  • T to C, chromosome 9 at 99,698,914 bp
  • C to A, chromosome 9 at 108,948,574 bp
  • T to C, chromosome 9 at 119,534,571 bp
  • C to T, chromosome 10 at 13,182,860 bp
  • C to A, chromosome 10 at 26,993,398 bp
  • A to G, chromosome 10 at 129,046,826 bp
  • T to C, chromosome 11 at 69,735,080 bp
  • A to G, chromosome 11 at 73,136,298 bp
  • A to G, chromosome 11 at 87,117,814 bp
  • C to T, chromosome 11 at 94,669,894 bp
  • G to A, chromosome 11 at 106,284,078 bp
  • T to C, chromosome 12 at 116,347,808 bp
  • A to G, chromosome 13 at 85,258,312 bp
  • A to G, chromosome 14 at 75,199,433 bp
  • G to T, chromosome 16 at 48,937,061 bp
  • G to A, chromosome 17 at 34,029,544 bp
  • G to A, chromosome 17 at 63,356,851 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0313 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038523-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.