Strain Name:
C57BL/6J-MtgxR0317Btlr/Mmmh
Stock Number:
038527-MU
Citation ID:
RRID:MMRRC_038527-MU
Other Names:
R0317 (G1), C57BL/6J-MtgxR0317Btlr
Major Collection:

Strain Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: D11Ertd530e, 2610028O16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Slc6a12
Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Synonyms: BGT1, Gabt2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14411
Homologene: 128225
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: Cla-1, D5Ertd460e, Hdlq1, Chohd1, Hlb398, SRBI, Srb1, Cd36l1, Chohd1, SR-BI
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Chgb
Name: chromogranin B
Synonyms: secretogranin I, Scg-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12653
HGNC: HGNC:1930
Homologene: 1375
Nms
Name: neuromedin S
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433292
Homologene: 67775
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Alp145, 140kDa, RFC140, Recc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Fry
Name: FRY microtubule binding protein
Synonyms: 9330186A19Rik, cg003
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Kifbp
Name: kinesin family binding protein
Synonyms: 2510003E04Rik, Kif1bp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72320
Homologene: 9223
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Ets2
Name: E26 avian leukemia oncogene 2, 3' domain
Synonyms: Ets-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23872
HGNC: HGNC:3489
Homologene: 3838
Arfip2
Name: ADP-ribosylation factor interacting protein 2
Synonyms: Arfaptin 2, 2310002N04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76932
Homologene: 8234
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Med29
Name: mediator complex subunit 29
Synonyms: 2810405O22Rik, Ixl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67224
Homologene: 12102
Pgr
Name: progesterone receptor
Synonyms: PR-A, 9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: Pumm2, 5730503J23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80913
Homologene: 69183
Cnpy4
Name: canopy FGF signaling regulator 4
Synonyms: 2610019P18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66455
Homologene: 15196
Recql5
Name: RecQ protein-like 5
Synonyms: Recq5b, Recql5b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Rbl2
Name: RB transcriptional corepressor like 2
Synonyms: p130, retinoblastoma-like 2, Rb2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19651
HGNC: HGNC:9894
Homologene: 4098
Rab11a
Name: RAB11A, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53869
HGNC: HGNC:9760
Homologene: 37903
Cert1
Name: ceramide transporter 1
Synonyms: GPBP, Cert, Col4a3bp, 9230101K08Rik, 2810404O15Rik, ceramide transport protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68018
VEGA: 13
HGNC: HGNC:2205
Homologene: 4173
Tmco1
Name: transmembrane and coiled-coil domains 1
Synonyms: 1190006A08Rik, ESTM39, 4930403O06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68944
Homologene: 10384
Clmn
Name: calmin
Synonyms: 9330188N17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94040
VEGA: 12
Homologene: 11683
Phactr4
Name: phosphatase and actin regulator 4
Synonyms: 3110001B12Rik, C330013F19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100169
Homologene: 41537
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100317
Homologene: 11764
Wdcp
Name: WD repeat and coiled coil containing
Synonyms: BC068281
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238037
VEGA: 12
Homologene: 49822
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Vmn1r206
Name: vomeronasal 1 receptor 206
Synonyms: V1rh7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171250
Homologene: 110880
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Tub
Name: TUB bipartite transcription factor
Synonyms: tub, rd5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22141
Homologene: 31147
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242505
Homologene: 28424
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Mfsd12
Name: major facilitator superfamily domain containing 12
Synonyms: gr, Wdt1, F630110N24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73822
Homologene: 45488
Pgm5
Name: phosphoglucomutase 5
Synonyms: aciculin, 9530034F03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226041
HGNC: HGNC:8908
Homologene: 74881
Lysmd4
Name: LysM, putative peptidoglycan-binding, domain containing 4
Synonyms: 4930506D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75099
Homologene: 45123
Ces1f
Name: carboxylesterase 1F
Synonyms: TGH-2, CesML1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234564
HGNC: HGNC:1863
Homologene: 134311
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: EG56544, V2r83
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56544
Homologene: 84832
Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Synonyms: Oatp1, Oatp1a1, Slc21a1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28248
Homologene: 137261
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: IId, IId/x, Myhs-f2, A530084A17Rik, MyHC-IId/x, Myhs-f, Myhsf2, MYHC-IIX, myosin heavy chain 2X
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: Anr1, OATP-D, 5830414C08Rik, Slc21a11, MJAM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108116
Homologene: 40862
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69847
Homologene: 13020
Ggn
Name: gametogenetin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243897
Homologene: 45139
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Or8g30
Name: olfactory receptor family 8 subfamily G member 30
Synonyms: MOR171-45, Olfr948, MOR171-51, GA_x6K02T2PVTD-33016899-33015934
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257912
VEGA: 9
HGNC: HGNC:8484
Homologene: 79377
Arhgef26
Name: Rho guanine nucleotide exchange factor 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 622434
Homologene: 9204
Lrrc15
Name: leucine rich repeat containing 15
Synonyms: 5430427N11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74488
Homologene: 26080
Pdhx
Name: pyruvate dehydrogenase complex, component X
Synonyms: Pdx1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27402
Homologene: 55757
Ces1e
Name: carboxylesterase 1E
Synonyms: egasyn, Es-22, Es22, Eg
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13897
HGNC: HGNC:1863
Homologene: 115660
Rpl27
Name: ribosomal protein L27
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19942
Homologene: 105144
Zkscan16
Name: zinc finger with KRAB and SCAN domains 16
Synonyms: Zfp483
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041581
Homologene: 26419
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 260305
Homologene: 9024
Slc2a4
Name: solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms: Glut-4, twgy, Glut4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20528
Homologene: 74381
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21897
Homologene: 20694
Cab39
Name: calcium binding protein 39
Synonyms: MO25alpha, 39kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12283
Homologene: 69212
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: 2810471M23Rik, Veph
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72789
Homologene: 11624
Cela2a
Name: chymotrypsin-like elastase family, member 2A
Synonyms: Ela-2, Ela2, Ela2a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13706
Homologene: 40598
Ufsp2
Name: UFM1-specific peptidase 2
Synonyms: 1810047C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 192169
Homologene: 10151
Crlf1
Name: cytokine receptor-like factor 1
Synonyms: cytokine receptor like molecule 3, CLF-1, CRLM3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12931
HGNC: HGNC:2364
Homologene: 3489
Gadd45gip1
Name: growth arrest and DNA-damage-inducible, gamma interacting protein 1
Synonyms: 2310040G17Rik, Crif1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102060
Homologene: 33474
4930538E20Rik
Name: RIKEN cDNA 4930538E20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78200
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Fam196b, Gm6041
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Nid1
Name: nidogen 1
Synonyms: entactin 1, entactin-1, entactin, nidogen-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Zfp503
Name: zinc finger protein 503
Synonyms: Zpo2, ZNF503, Nolz1, B830002A16Rik, Nolz-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218820
Homologene: 41888
Gm5239
Name: predicted pseudogene 5239
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 383341
VEGA: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 14,881,632 bp
  • A to G, chromosome 1 at 38,947,607 bp
  • T to A, chromosome 1 at 46,134,656 bp
  • A to G, chromosome 1 at 85,849,160 bp
  • T to C, chromosome 1 at 167,325,893 bp
  • A to G, chromosome 2 at 103,028,280 bp
  • A to G, chromosome 2 at 132,793,811 bp
  • C to T, chromosome 3 at 19,971,095 bp
  • T to C, chromosome 3 at 62,423,544 bp
  • T to C, chromosome 3 at 64,081,819 bp
  • T to C, chromosome 3 at 66,171,975 bp
  • T to G, chromosome 3 at 76,589,114 bp
  • G to A, chromosome 4 at 58,957,602 bp
  • T to C, chromosome 4 at 73,748,562 bp
  • G to A, chromosome 4 at 126,837,429 bp
  • T to A, chromosome 4 at 132,386,930 bp
  • A to T, chromosome 4 at 141,821,700 bp
  • T to A, chromosome 4 at 152,551,931 bp
  • C to A, chromosome 5 at 31,072,321 bp
  • T to C, chromosome 5 at 43,706,901 bp
  • G to T, chromosome 5 at 64,925,967 bp
  • A to T, chromosome 5 at 65,296,052 bp
  • A to G, chromosome 5 at 125,289,692 bp
  • C to T, chromosome 5 at 138,192,812 bp
  • T to C, chromosome 5 at 150,471,468 bp
  • A to G, chromosome 6 at 121,358,625 bp
  • A to G, chromosome 6 at 141,911,942 bp
  • T to C, chromosome 7 at 28,386,859 bp
  • T to A, chromosome 7 at 29,171,090 bp
  • A to G, chromosome 7 at 67,226,297 bp
  • A to C, chromosome 7 at 74,504,426 bp
  • T to C, chromosome 7 at 81,463,681 bp
  • G to A, chromosome 7 at 105,637,223 bp
  • A to T, chromosome 7 at 109,020,927 bp
  • G to A, chromosome 8 at 43,652,251 bp
  • G to A, chromosome 8 at 45,992,233 bp
  • A to G, chromosome 8 at 70,498,599 bp
  • G to A, chromosome 8 at 84,834,116 bp
  • A to G, chromosome 8 at 91,087,144 bp
  • A to C, chromosome 8 at 93,224,039 bp
  • A to T, chromosome 8 at 93,263,391 bp
  • A to T, chromosome 9 at 8,965,022 bp
  • A to G, chromosome 9 at 39,319,461 bp
  • A to G, chromosome 9 at 64,725,553 bp
  • A to T, chromosome 10 at 62,578,082 bp
  • G to T, chromosome 10 at 81,357,799 bp
  • T to C, chromosome 11 at 9,293,459 bp
  • A to T, chromosome 11 at 24,172,697 bp
  • C to A, chromosome 11 at 34,402,826 bp
  • T to C, chromosome 11 at 67,217,512 bp
  • C to T, chromosome 11 at 69,946,356 bp
  • T to A, chromosome 11 at 79,999,078 bp
  • T to C, chromosome 11 at 101,268,804 bp
  • G to A, chromosome 11 at 101,443,495 bp
  • A to G, chromosome 11 at 115,894,673 bp
  • A to G, chromosome 12 at 4,851,583 bp
  • T to A, chromosome 12 at 8,728,754 bp
  • C to T, chromosome 12 at 104,780,708 bp
  • C to T, chromosome 13 at 13,499,796 bp
  • A to G, chromosome 13 at 22,620,960 bp
  • C to T, chromosome 13 at 96,634,121 bp
  • T to C, chromosome 14 at 21,986,459 bp
  • A to T, chromosome 16 at 30,273,743 bp
  • G to A, chromosome 16 at 95,712,149 bp
  • A to G, chromosome 18 at 35,536,916 bp
  • A to G, chromosome 19 at 24,824,399 bp
  • A to G, chromosome 19 at 46,254,020 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0317 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038527-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.