Strain Name:
C57BL/6J-MtgxR0319Btlr/Mmmh
Stock Number:
038529-MU
Citation ID:
RRID:MMRRC_038529-MU
Other Names:
R0319 (G1), C57BL/6J-MtgxR0319Btlr
Major Collection:

Gene Information

Draxin
Name: dorsal inhibitory axon guidance protein
Synonyms: Neucrin, 2610109H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70433
Homologene: 19233
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: LOC237877, C130052G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237877
Homologene: 32611
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Anapc5
Name: anaphase-promoting complex subunit 5
Synonyms: 2510006G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 59008
Homologene: 41118
Kif20b
Name: kinesin family member 20B
Synonyms: N-6 kinesin, C330014J10Rik, Kif20b, Mphosph1, 33cex, magoo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240641
VEGA: 19
HGNC: HGNC:7212
Homologene: 9418
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Atxn10
Name: ataxin 10
Synonyms: TEG-169, E46, Sca10, Tex169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54138
VEGA: 15
Homologene: 40858
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: 5230400C17Rik, Pip5k3, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18711
Homologene: 32115
Slc49a4
Name: solute carrier family 49 member 4
Synonyms: RCC4, Dirc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224132
Homologene: 13137
Tpd52
Name: tumor protein D52
Synonyms: mD52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 21985
Homologene: 38007
Exosc7
Name: exosome component 7
Synonyms: 2610002K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66446
Homologene: 8994
Kdelr2
Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Synonyms: 1110007A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66913
HGNC: HGNC:6305
Homologene: 129146
Tor1aip1
Name: torsin A interacting protein 1
Synonyms: LAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208263
Homologene: 9208
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Rtp1
Name: receptor transporter protein 1
Synonyms: LOC239766, LOC385871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239766
VEGA: 16
Homologene: 17806
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Casr-rs2, EG637873, Gprc2a-rs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637873
Homologene: 129683
Dbn1
Name: drebrin 1
Synonyms: drebrin E2, drebrin A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56320
HGNC: HGNC:2695
Homologene: 3236
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Abcb1b
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms: Mdr1, Mdr1b, mdr, Pgy1, Pgy-1, Abcb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18669
Homologene: 69084
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: RIP3, p116Rip, p116 Rho interacting protein, Rhoip3, Gm34094
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26936
Homologene: 9034
Slc17a3
Name: solute carrier family 17 (sodium phosphate), member 3
Synonyms: Npt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105355
Homologene: 21319
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: 4632428N09Rik, Aof1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218214
Homologene: 14695
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74711
Homologene: 41769
Trim67
Name: tripartite motif-containing 67
Synonyms: D130049O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330863
Homologene: 45699
Zfp595
Name: zinc finger protein 595
Synonyms: A230042K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218314
Homologene: 120258
Kcnv2
Name: potassium channel, subfamily V, member 2
Synonyms: KV11.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240595
Homologene: 26423
Ankmy2
Name: ankyrin repeat and MYND domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217473
VEGA: 12
Homologene: 10662
Cpne9
Name: copine family member IX
Synonyms: A730016F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 211232
Homologene: 84686
Kcnip1
Name: Kv channel-interacting protein 1
Synonyms: 2900046L02Rik, KCHIP1, 3202002F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70357
Homologene: 22824
Rpl27
Name: ribosomal protein L27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19942
Homologene: 105144
Zfp759
Name: zinc finger protein 759
Synonyms: Rslcan-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 268670
VEGA: 13
Arhgef19
Name: Rho guanine nucleotide exchange factor (GEF) 19
Synonyms: 6430573B13Rik, WGEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 213649
Homologene: 17710
Spdl1
Name: spindle apparatus coiled-coil protein 1
Synonyms: 1700018I02Rik, 2810049B11Rik, 2600001J17Rik, Ccdc99
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70385
Homologene: 9837
Actg2
Name: actin, gamma 2, smooth muscle, enteric
Synonyms: SMGA, Act-4, Act4, Acta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11468
HGNC: HGNC:145
Homologene: 123845
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: CD106, Vcam-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22329
Homologene: 838
Sgk2
Name: serum/glucocorticoid regulated kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27219
Homologene: 8446
Klhl9
Name: kelch-like 9
Synonyms: C530050O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242521
Homologene: 23125
Cyp3a13
Name: cytochrome P450, family 3, subfamily a, polypeptide 13
Synonyms: IIIAm2, steroid inducible
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13113
HGNC: HGNC:2640
Homologene: 133564
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171200
Homologene: 134034
Mgst1
Name: microsomal glutathione S-transferase 1
Synonyms: 1500002K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56615
HGNC: HGNC:7061
Homologene: 10544
Lmo3
Name: LIM domain only 3
Synonyms: Rbtn-3, Rbtn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109593
HGNC: HGNC:6643
Homologene: 38552
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330450
Homologene: 69247
Zfp109
Name: zinc finger protein 109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56869
9130023H24Rik
Name: RIKEN cDNA 9130023H24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043133
Ankk1
Name: ankyrin repeat and kinase domain containing 1
Synonyms: 9930020N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244859
VEGA: 9
Homologene: 18258
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: DNF15S2h, D9H3F15S2, D3F15S2h, Hgfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15235
HGNC: HGNC:7380
Homologene: 7360
Mob3a
Name: MOB kinase activator 3A
Synonyms: 5330417K06Rik, Mobkl2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 208228
VEGA: 10
Homologene: 41587
Lgals3bp
Name: lectin, galactoside-binding, soluble, 3 binding protein
Synonyms: CyCAP, MAC-2BP, 90K, Ppicap, Tango10b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19039
HGNC: HGNC:6564
Homologene: 4067
Ggps1
Name: geranylgeranyl diphosphate synthase 1
Synonyms: GGPP synthase, 9530089B04Rik, 1810026C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14593
VEGA: 13
HGNC: HGNC:4249
Homologene: 31267
Rcbtb2
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Synonyms: 2810420M18Rik, 2610028E02Rik, Chc1l, Rc/btb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105670
HGNC: HGNC:1914
Homologene: 970
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 210530
Homologene: 10062
Lvrn
Name: laeverin
Synonyms: 4833403I15Rik, Aqpep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74574
VEGA: 18
Homologene: 51352
Olfr1437
Name: olfactory receptor 1437
Synonyms: GA_x6K02T2RE5P-2658227-2657289, MOR214-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258117
Homologene: 83129
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 65,246,331 bp
  • T to C, chromosome 1 at 90,807,704 bp
  • T to C, chromosome 1 at 136,070,717 bp
  • T to C, chromosome 1 at 156,007,181 bp
  • T to C, chromosome 1 at 188,948,374 bp
  • C to A, chromosome 2 at 153,000,098 bp
  • T to C, chromosome 2 at 162,995,672 bp
  • T to C, chromosome 3 at 8,953,689 bp
  • T to C, chromosome 3 at 116,116,060 bp
  • A to T, chromosome 4 at 88,720,454 bp
  • A to T, chromosome 4 at 141,256,399 bp
  • A to G, chromosome 4 at 148,115,972 bp
  • A to G, chromosome 5 at 8,827,428 bp
  • A to G, chromosome 5 at 122,818,856 bp
  • G to A, chromosome 5 at 137,898,862 bp
  • T to A, chromosome 5 at 143,412,517 bp
  • T to A, chromosome 6 at 57,404,615 bp
  • T to A, chromosome 6 at 83,520,743 bp
  • G to A, chromosome 6 at 113,294,693 bp
  • A to G, chromosome 6 at 138,156,157 bp
  • G to A, chromosome 6 at 138,377,311 bp
  • A to G, chromosome 6 at 148,157,470 bp
  • A to T, chromosome 7 at 24,234,470 bp
  • T to A, chromosome 7 at 42,300,517 bp
  • A to C, chromosome 7 at 128,237,190 bp
  • A to T, chromosome 8 at 124,823,227 bp
  • T to G, chromosome 9 at 49,416,071 bp
  • A to G, chromosome 9 at 108,082,513 bp
  • T to A, chromosome 9 at 123,130,960 bp
  • A to T, chromosome 10 at 80,689,985 bp
  • T to C, chromosome 11 at 33,651,529 bp
  • T to C, chromosome 11 at 34,823,520 bp
  • T to A, chromosome 11 at 59,697,038 bp
  • T to A, chromosome 11 at 80,120,790 bp
  • A to G, chromosome 11 at 100,504,982 bp
  • G to A, chromosome 11 at 101,443,495 bp
  • A to G, chromosome 11 at 118,393,521 bp
  • T to C, chromosome 12 at 36,165,899 bp
  • C to T, chromosome 12 at 76,064,162 bp
  • A to C, chromosome 13 at 14,053,877 bp
  • C to T, chromosome 13 at 23,855,858 bp
  • C to T, chromosome 13 at 47,053,719 bp
  • C to T, chromosome 13 at 55,474,916 bp
  • A to G, chromosome 13 at 67,140,292 bp
  • G to A, chromosome 13 at 67,316,513 bp
  • G to A, chromosome 14 at 73,178,469 bp
  • T to C, chromosome 15 at 85,365,282 bp
  • G to A, chromosome 16 at 23,431,460 bp
  • T to A, chromosome 16 at 25,970,931 bp
  • T to C, chromosome 16 at 35,750,514 bp
  • T to A, chromosome 17 at 73,906,101 bp
  • C to A, chromosome 18 at 46,864,753 bp
  • A to T, chromosome 19 at 12,322,316 bp
  • A to T, chromosome 19 at 27,324,024 bp
  • G to A, chromosome 19 at 34,947,732 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0319 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038529-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.