Strain Name:
C57BL/6J-MtgxR0345Btlr/Mmmh
Stock Number:
038552-MU
Citation ID:
RRID:MMRRC_038552-MU
Other Names:
R0345 (G1), C57BL/6J-MtgxR0345Btlr
Major Collection:

Gene Information

Chrnb4
Name: cholinergic receptor, nicotinic, beta polypeptide 4
Synonyms: Acrb-4, Acrb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108015
VEGA: 9
HGNC: HGNC:1964
Homologene: 20196
Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Prdm16
Name: PR domain containing 16
Synonyms: Mel1, 5730557K01Rik, line 27, csp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70673
Homologene: 11139
Sntb2
Name: syntrophin, basic 2
Synonyms: Snt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20650
Homologene: 4911
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22222
Homologene: 7582
Ap2a2
Name: adaptor-related protein complex 2, alpha 2 subunit
Synonyms: alpha-C adaptin, alpha-adaptin C, L25, Adtab, 2410074K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11772
HGNC: HGNC:562
Homologene: 5335
Nckap1
Name: NCK-associated protein 1
Synonyms: mh19, Hem-2, H19, Nap1, Hem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, 6530403D07Rik, D2Ertd145e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 51869
Homologene: 41231
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229681
Homologene: 14910
Aff4
Name: AF4/FMR2 family, member 4
Synonyms: Alf4, Laf4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 93736
Homologene: 8683
Bcl7c
Name: B cell CLL/lymphoma 7C
Synonyms: C230096E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12055
HGNC: HGNC:1006
Homologene: 3498
Syt13
Name: synaptotagmin XIII
Synonyms: 5730409J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80976
Homologene: 10823
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109242
Homologene: 52346
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: mSiglec-F, Siglec5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233186
Homologene: 50482
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Zscan10
Name: zinc finger and SCAN domain containing 10
Synonyms: Zscan10, Zfp206
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 332221
Homologene: 13122
Chia1
Name: chitinase, acidic 1
Synonyms: AMCase, YNL, 2200003E03Rik, Chia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 81600
Homologene: 75168
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195046
Homologene: 133820
Synm
Name: synemin, intermediate filament protein
Synonyms: 4930412K21Rik, Synemin, Dmn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233335
Homologene: 9081
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Stap2
Name: signal transducing adaptor family member 2
Synonyms: STAP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106766
VEGA: 17
Homologene: 9798
Chmp6
Name: charged multivesicular body protein 6
Synonyms: 2400004G01Rik, chromatin modifying protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 208092
Homologene: 11607
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Egflam
Name: EGF-like, fibronectin type III and laminin G domains
Synonyms: nectican, pikachurin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268780
Homologene: 65044
Fam228b
Name: family with sequence similarity 228, member B
Synonyms: A830093I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207921
VEGA: 12
Homologene: 116108
Or52e18
Name: olfactory receptor family 52 subfamily E member 18
Synonyms: GA_x6K02T2PBJ9-7589577-7588639, MOR32-8, Olfr670
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384703
Homologene: 105163
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: t2md1, LLGL4, A830015P08Rik, insulin level locus 1, tomosyn-2, T2dm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207227
Homologene: 18173
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Or5ak22
Name: olfactory receptor family 5 subfamily AK member 22
Synonyms: GA_x6K02T2Q125-46877170-46876241, MOR203-1, Olfr992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258865
Homologene: 121517
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
1700129C05Rik
Name: RIKEN cDNA 1700129C05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67932
Homologene: 130749
Tubb2a
Name: tubulin, beta 2A class IIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 22151
VEGA: 13
Homologene: 134314
Sorcs2
Name: sortilin-related VPS10 domain containing receptor 2
Synonyms: VPS10 domain receptor protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 81840
Homologene: 56899
Or2ag2b
Name: olfactory receptor family 2 subfamily AG member 2B
Synonyms: 4932441H21Rik, GA_x6K02T2PBJ9-9195805-9196755, MOR283-1, 4933433E02Rik, Olfr701
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66786
Homologene: 12558
Nol4l
Name: nucleolar protein 4-like
Synonyms: LOC381396, 8430427H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329540
Homologene: 129589
Fam205a1
Name: family with sequence similarity 205, member A1
Synonyms: Gm12429
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433698
Homologene: 79022
Or5h26
Name: olfactory receptor family 5 subfamily H member 26
Synonyms: GA_x54KRFPKG5P-55389051-55388122, MOR183-1, Olfr196
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258775
Homologene: 74113
Zyg11b
Name: zyg-ll family member B, cell cycle regulator
Synonyms: LOC242610, 1110046I03Rik, D4Mgi23, 2810482G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 414872
Homologene: 14600
Gbp2b
Name: guanylate binding protein 2b
Synonyms: Mag-1, Gbp-1, Mpa-1, Mpa1, Gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14468
HGNC: HGNC:4183
Homologene: 137233
Tent5b
Name: terminal nucleotidyltransferase 5B
Synonyms: 4732473B16Rik, Fam46b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100342
Homologene: 24928
Sgce
Name: sarcoglycan, epsilon
Synonyms: e-SG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20392
Homologene: 31205
AC150897.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Ttll13
Name: tubulin tyrosine ligase-like family, member 13
Synonyms: 1700111A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269954
Homologene: 136186
Ctnna3
Name: catenin (cadherin associated protein), alpha 3
Synonyms: Vr22, Catna3, 4930429L08Rik, alphaT-catenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Cd7
Name: CD7 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12516
HGNC: HGNC:1695
Homologene: 4471
Dydc2
Name: DPY30 domain containing 2
Synonyms: 4933428D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71200
VEGA: 14
Homologene: 49996
Kcnq3
Name: potassium voltage-gated channel, subfamily Q, member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110862
HGNC: HGNC:6297
Homologene: 20949
Cyp2d37-ps
Name: cytochrome P450, family 2, subfamily d, polypeptide 37, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 627860
VEGA: 15
Themis3
Name: thymocyte selection associated family member 3
Synonyms: 9130404H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74556
Homologene: 137389
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • GCCACCA to GCCA, chromosome 2 at 52,110,324 bp
  • G to T, chromosome 2 at 80,544,977 bp
  • T to C, chromosome 2 at 85,400,341 bp
  • A to C, chromosome 2 at 92,946,067 bp
  • T to C, chromosome 2 at 120,904,103 bp
  • T to A, chromosome 2 at 153,411,752 bp
  • T to C, chromosome 3 at 104,895,809 bp
  • T to C, chromosome 3 at 106,122,439 bp
  • T to C, chromosome 3 at 142,608,183 bp
  • A to T, chromosome 4 at 41,428,413 bp
  • T to C, chromosome 4 at 42,851,116 bp
  • A to G, chromosome 4 at 108,266,407 bp
  • A to T, chromosome 4 at 133,486,211 bp
  • A to T, chromosome 4 at 145,117,625 bp
  • T to C, chromosome 4 at 154,341,111 bp
  • C to T, chromosome 5 at 36,027,874 bp
  • G to A, chromosome 6 at 4,718,019 bp
  • A to G, chromosome 6 at 23,016,165 bp
  • T to C, chromosome 6 at 73,021,257 bp
  • T to C, chromosome 6 at 121,638,272 bp
  • T to C, chromosome 7 at 43,351,944 bp
  • C to T, chromosome 7 at 45,259,248 bp
  • C to T, chromosome 7 at 67,735,821 bp
  • T to A, chromosome 7 at 80,247,336 bp
  • T to A, chromosome 7 at 104,960,181 bp
  • T to C, chromosome 7 at 106,818,701 bp
  • A to T, chromosome 7 at 127,708,463 bp
  • T to A, chromosome 7 at 141,631,293 bp
  • T to C, chromosome 8 at 107,001,538 bp
  • C to T, chromosome 8 at 123,304,813 bp
  • T to A, chromosome 9 at 42,384,218 bp
  • A to G, chromosome 9 at 55,035,594 bp
  • A to G, chromosome 9 at 75,297,419 bp
  • A to G, chromosome 10 at 63,566,840 bp
  • A to G, chromosome 10 at 127,087,895 bp
  • T to A, chromosome 11 at 53,372,881 bp
  • C to A, chromosome 11 at 71,123,675 bp
  • T to C, chromosome 11 at 100,757,681 bp
  • A to G, chromosome 11 at 115,849,992 bp
  • T to C, chromosome 11 at 119,918,046 bp
  • T to C, chromosome 11 at 121,038,186 bp
  • C to T, chromosome 12 at 4,748,351 bp
  • A to C, chromosome 13 at 34,076,637 bp
  • C to A, chromosome 14 at 41,061,946 bp
  • T to C, chromosome 14 at 59,139,630 bp
  • T to A, chromosome 14 at 101,876,877 bp
  • G to T, chromosome 15 at 7,289,994 bp
  • A to T, chromosome 15 at 66,020,305 bp
  • A to G, chromosome 15 at 74,543,349 bp
  • G to T, chromosome 15 at 76,177,167 bp
  • A to T, chromosome 15 at 80,372,462 bp
  • A to T, chromosome 15 at 82,689,774 bp
  • A to T, chromosome 16 at 37,288,308 bp
  • G to A, chromosome 16 at 59,167,906 bp
  • T to A, chromosome 17 at 23,610,082 bp
  • A to G, chromosome 17 at 56,000,097 bp
  • A to T, chromosome 17 at 66,559,545 bp
  • A to T, chromosome 19 at 38,024,345 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0345 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038552-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.