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Strain Name:
C57BL/6J-MtgxR0359Btlr/Mmmh
Stock Number:
038565-MU
Citation ID:
RRID:MMRRC_038565-MU
Other Names:
R0359 (G1), C57BL/6J-MtgxR0359Btlr
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Glrx3
Name: glutaredoxin 3
Synonyms: PKC interacting cousin of thioredoxin, PICOT, Txnl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30926
Homologene: 4769
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Ppp1r1a
Name: protein phosphatase 1, regulatory inhibitor subunit 1A
Synonyms: I-1, protein phosphatase inhibitor-1, inhibitor-1, 0610038N18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58200
VEGA: 15
HGNC: HGNC:9286
Homologene: 4905
Diaph3
Name: diaphanous related formin 3
Synonyms: p134MDia2, mDia2, 4930417P13Rik, Drf3, Diap3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Kpna2
Name: karyopherin subunit alpha 2
Synonyms: pendulin, m-importin, m-importin-alpha-P1, Rch1, 2410044B12Rik, Importin alpha, importin alpha 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16647
HGNC: HGNC:6395
Homologene: 1708
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 36,069,185 bp
  • T to A, chromosome 1 at 74,920,601 bp
  • T to A, chromosome 1 at 98,466,697 bp
  • T to G, chromosome 1 at 164,179,449 bp
  • G to A, chromosome 2 at 76,719,057 bp
  • T to A, chromosome 2 at 170,491,699 bp
  • A to T, chromosome 3 at 41,661,570 bp
  • T to C, chromosome 3 at 122,255,620 bp
  • C to T, chromosome 4 at 3,904,546 bp
  • A to G, chromosome 4 at 55,013,689 bp
  • G to T, chromosome 4 at 63,314,727 bp
  • G to A, chromosome 4 at 135,778,143 bp
  • T to C, chromosome 4 at 141,516,870 bp
  • A to G, chromosome 4 at 141,793,910 bp
  • G to A, chromosome 5 at 22,048,800 bp
  • T to C, chromosome 5 at 87,250,584 bp
  • A to T, chromosome 5 at 87,964,596 bp
  • G to A, chromosome 5 at 96,762,590 bp
  • T to C, chromosome 5 at 100,790,200 bp
  • T to A, chromosome 5 at 145,045,371 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • G to A, chromosome 6 at 12,352,031 bp
  • T to A, chromosome 6 at 22,973,176 bp
  • G to A, chromosome 6 at 25,771,680 bp
  • A to T, chromosome 6 at 126,934,741 bp
  • G to A, chromosome 6 at 140,591,747 bp
  • A to T, chromosome 7 at 10,527,274 bp
  • T to A, chromosome 7 at 12,259,950 bp
  • T to C, chromosome 7 at 19,579,939 bp
  • C to T, chromosome 7 at 80,391,284 bp
  • A to T, chromosome 7 at 104,893,314 bp
  • C to T, chromosome 7 at 108,565,514 bp
  • T to C, chromosome 7 at 137,453,485 bp
  • T to C, chromosome 7 at 144,485,192 bp
  • G to T, chromosome 8 at 15,042,540 bp
  • A to T, chromosome 8 at 43,130,505 bp
  • T to C, chromosome 8 at 93,328,535 bp
  • T to C, chromosome 8 at 110,893,259 bp
  • T to C, chromosome 8 at 121,085,003 bp
  • T to G, chromosome 8 at 122,478,193 bp
  • G to T, chromosome 9 at 8,972,436 bp
  • C to T, chromosome 9 at 89,699,789 bp
  • T to A, chromosome 9 at 105,997,146 bp
  • C to T, chromosome 9 at 108,111,846 bp
  • A to G, chromosome 10 at 78,917,343 bp
  • G to A, chromosome 11 at 69,529,531 bp
  • A to G, chromosome 11 at 71,766,866 bp
  • G to A, chromosome 11 at 76,212,162 bp
  • A to G, chromosome 11 at 102,406,569 bp
  • A to G, chromosome 11 at 106,991,322 bp
  • A to T, chromosome 11 at 108,397,373 bp
  • T to A, chromosome 12 at 38,216,031 bp
  • A to G, chromosome 12 at 118,940,332 bp
  • T to G, chromosome 13 at 74,157,607 bp
  • T to C, chromosome 14 at 86,969,502 bp
  • A to T, chromosome 14 at 121,255,396 bp
  • A to G, chromosome 14 at 123,299,168 bp
  • A to G, chromosome 15 at 55,407,868 bp
  • A to G, chromosome 15 at 100,211,993 bp
  • T to A, chromosome 15 at 103,533,488 bp
  • A to G, chromosome 16 at 37,216,078 bp
  • A to G, chromosome 16 at 73,978,623 bp
  • A to G, chromosome 16 at 90,791,160 bp
  • A to G, chromosome 17 at 34,610,577 bp
  • G to T, chromosome 17 at 47,341,136 bp
  • T to C, chromosome 18 at 12,148,949 bp
  • A to G, chromosome 19 at 16,641,577 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0359 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038565-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.