Strain Name:
C57BL/6J-MtgxR0381Btlr/Mmmh
Stock Number:
038587-MU
Citation ID:
RRID:MMRRC_038587-MU
Other Names:
R0381 (G1), C57BL/6J-MtgxR0381Btlr
Major Collection:

Gene Information

Mitf
Name: melanogenesis associated transcription factor
Synonyms: bHLHe32, Gsfbcc2, mi, wh, BCC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17342
HGNC: HGNC:7105
Homologene: 4892
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: A630020C16Rik, 4930502N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74996
Homologene: 9929
Sephs1
Name: selenophosphate synthetase 1
Synonyms: SPS1, 1110046B24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109079
Homologene: 56558
Abcc8
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Synonyms: D930031B21Rik, Sur, SUR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, 2610202A04Rik, D16Ium21e, D16Ium21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22129
Homologene: 2487
Tasp1
Name: taspase, threonine aspartase 1
Synonyms: 4930485D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75812
Homologene: 9795
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: F730017H24Rik, sys, 1700094E19Rik, Fndc3, D14Ertd453e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319448
Homologene: 8952
Fnbp1
Name: formin binding protein 1
Synonyms: FBP17, FBP1, 1110057E06Rik, 2210010H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14269
Homologene: 100983
Kctd5
Name: potassium channel tetramerisation domain containing 5
Synonyms: 2610030N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69259
Homologene: 10363
Clca2
Name: chloride channel accessory 2
Synonyms: Clca5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229933
HGNC: HGNC:2016
Homologene: 4765
Eif4g1
Name: eukaryotic translation initiation factor 4, gamma 1
Synonyms: E030015G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208643
HGNC: HGNC:3296
Homologene: 110725
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: ELM2, Ten-m4, Odz4, Doc4, l7Rn3, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23966
Homologene: 8034
Klrb1c
Name: killer cell lectin-like receptor subfamily B member 1C
Synonyms: Ly55c, Nk1, NKR-P1C, Nkrp1-c, NKR-P1, Ly-59, CD161, Nk-1.2, NK-1.1, Nk-1, Nk1.1, NK-RP1, Ly59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17059
HGNC: HGNC:6373
Homologene: 84369
Fcrl5
Name: Fc receptor-like 5
Synonyms: mBXMH2, Fcrh3, BXMAS1-like protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329693
Homologene: 137404
Akap11
Name: A kinase (PRKA) anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Anpep
Name: alanyl (membrane) aminopeptidase
Synonyms: Cd13, aminopeptidase N, Apn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Dennd1c
Name: DENN/MADD domain containing 1C
Synonyms: 4432409M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70785
VEGA: 17
Homologene: 11773
Hmcn1
Name: hemicentin 1
Synonyms: EG545370, LOC240793
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: CD169, Siglec-1, Sn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20612
Homologene: 124458
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14918
Homologene: 71540
Trim34b
Name: tripartite motif-containing 34B
Synonyms: Gm15134, Trim34-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434218
Homologene: 128238
Ntsr2
Name: neurotensin receptor 2
Synonyms: NT2R, NTRL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18217
VEGA: 12
HGNC: HGNC:8040
Homologene: 7452
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22313
Homologene: 129751
Mmut
Name: methylmalonyl-Coenzyme A mutase
Synonyms: Mut, D230010K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17850
VEGA: 17
HGNC: HGNC:7526
Homologene: 20097
Mylk
Name: myosin, light polypeptide kinase
Synonyms: A930019C19Rik, nmMlck, Mlck, telokin, MLCK210, 9530072E15Rik, MLCK108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf13b, Cf-13b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Sypl2
Name: synaptophysin-like 2
Synonyms: Mg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17306
Homologene: 7421
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72277
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: Ccp2, Ccp2, A430081C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271813
Homologene: 11715
Mrm1
Name: mitochondrial rRNA methyltransferase 1
Synonyms: A530065E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217038
Homologene: 40307
Tcam1
Name: testicular cell adhesion molecule 1
Synonyms: 4930570F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75870
Homologene: 123944
Tmc1
Name: transmembrane channel-like gene family 1
Synonyms: Bth, Beethoven, 4933416G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13409
VEGA: 19
Homologene: 23670
Vmn1r201
Name: vomeronasal 1 receptor 201
Synonyms: V1ri4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171255
Homologene: 110880
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75721
Homologene: 138468
Ccdc66
Name: coiled-coil domain containing 66
Synonyms: E230015L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 320234
VEGA: 14
Homologene: 35309
Gm7592
Name: predicted gene 7592
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 101055758
Immp1l
Name: IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Synonyms: 2610528O17Rik, 1500034J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66541
Homologene: 41747
Wscd2
Name: WSC domain containing 2
Synonyms: C530024P05Rik, 4933413A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320916
Homologene: 35372
Mettl24
Name: methyltransferase like 24
Synonyms: 9030224M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327747
Homologene: 65335
BC048403
Name: cDNA sequence BC048403
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 270802
Homologene: 17580
Nab2
Name: Ngfi-A binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17937
HGNC: HGNC:7627
Homologene: 4353
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 85,526,716 bp
  • A to G, chromosome 1 at 139,510,859 bp
  • C to T, chromosome 1 at 150,603,811 bp
  • A to G, chromosome 2 at 4,899,560 bp
  • G to A, chromosome 2 at 14,307,909 bp
  • C to T, chromosome 2 at 31,033,029 bp
  • C to T, chromosome 2 at 68,716,126 bp
  • G to A, chromosome 2 at 69,521,705 bp
  • C to T, chromosome 2 at 90,784,098 bp
  • T to A, chromosome 2 at 105,965,252 bp
  • C to T, chromosome 2 at 131,074,525 bp
  • T to C, chromosome 2 at 139,951,483 bp
  • T to C, chromosome 3 at 87,446,460 bp
  • T to C, chromosome 3 at 108,226,157 bp
  • T to C, chromosome 3 at 145,086,533 bp
  • T to A, chromosome 5 at 113,551,131 bp
  • A to G, chromosome 6 at 97,993,143 bp
  • T to C, chromosome 6 at 128,785,921 bp
  • A to G, chromosome 7 at 46,108,434 bp
  • C to T, chromosome 7 at 79,838,230 bp
  • G to T, chromosome 7 at 96,905,881 bp
  • C to A, chromosome 7 at 98,459,002 bp
  • T to C, chromosome 7 at 104,329,855 bp
  • T to C, chromosome 7 at 112,063,393 bp
  • C to A, chromosome 10 at 40,746,390 bp
  • T to C, chromosome 10 at 121,745,375 bp
  • G to A, chromosome 10 at 127,665,067 bp
  • T to C, chromosome 11 at 84,818,683 bp
  • G to A, chromosome 11 at 106,284,078 bp
  • T to A, chromosome 12 at 16,659,718 bp
  • T to A, chromosome 13 at 22,475,023 bp
  • T to A, chromosome 14 at 27,491,933 bp
  • A to G, chromosome 14 at 72,556,627 bp
  • A to T, chromosome 14 at 78,513,550 bp
  • A to C, chromosome 15 at 99,942,174 bp
  • T to C, chromosome 16 at 20,688,966 bp
  • G to A, chromosome 16 at 34,784,974 bp
  • T to A, chromosome 16 at 94,454,538 bp
  • A to T, chromosome 17 at 20,048,002 bp
  • A to G, chromosome 17 at 24,059,220 bp
  • T to A, chromosome 17 at 40,937,258 bp
  • G to A, chromosome 17 at 57,073,822 bp
  • T to C, chromosome 19 at 20,799,045 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0381 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038587-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.