Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR0390Btlr/Mmmh
Stock Number:
038596-MU
Citation ID:
RRID:MMRRC_038596-MU
Other Names:
R0390 (G1), C57BL/6J-MtgxR0390Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Sigmar1
Name: sigma non-opioid intracellular receptor 1
Synonyms: mSigmaR1, Oprs1, Sig1R
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18391
HGNC: HGNC:8157
Homologene: 39965
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Ap2m1
Name: adaptor-related protein complex 2, mu 1 subunit
Synonyms: clathrin-associated AP-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11773
HGNC: HGNC:564
Homologene: 3000
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: Sumo-1 activating enzyme subunit 2, UBA2, anthracycline-associated resistance, Arx, SAE2, Uble1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50995
Homologene: 4018
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,248,634 bp
  • T to A, chromosome 1 at 11,089,706 bp
  • C to T, chromosome 1 at 22,596,526 bp
  • A to G, chromosome 1 at 24,289,655 bp
  • T to G, chromosome 1 at 87,184,730 bp
  • T to C, chromosome 1 at 125,585,095 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • T to C, chromosome 1 at 135,449,966 bp
  • G to A, chromosome 1 at 138,122,575 bp
  • G to A, chromosome 1 at 162,538,889 bp
  • A to C, chromosome 1 at 169,525,297 bp
  • A to G, chromosome 1 at 178,957,573 bp
  • A to G, chromosome 2 at 5,046,195 bp
  • T to A, chromosome 2 at 6,018,894 bp
  • C to T, chromosome 2 at 30,108,213 bp
  • T to C, chromosome 2 at 76,756,931 bp
  • T to C, chromosome 2 at 94,114,990 bp
  • C to T, chromosome 2 at 101,688,588 bp
  • T to A, chromosome 2 at 124,658,490 bp
  • T to C, chromosome 2 at 125,576,869 bp
  • T to C, chromosome 2 at 157,114,231 bp
  • G to T, chromosome 2 at 160,752,366 bp
  • T to A, chromosome 3 at 93,200,355 bp
  • A to T, chromosome 3 at 98,853,039 bp
  • T to G, chromosome 3 at 122,835,583 bp
  • C to T, chromosome 4 at 41,741,243 bp
  • T to A, chromosome 4 at 65,351,613 bp
  • C to A, chromosome 4 at 112,389,179 bp
  • C to T, chromosome 4 at 119,368,025 bp
  • T to C, chromosome 4 at 128,133,673 bp
  • A to T, chromosome 4 at 129,657,804 bp
  • A to G, chromosome 4 at 134,578,315 bp
  • T to A, chromosome 4 at 143,811,699 bp
  • T to A, chromosome 5 at 87,464,148 bp
  • A to T, chromosome 5 at 138,607,225 bp
  • T to C, chromosome 6 at 30,447,412 bp
  • T to G, chromosome 6 at 36,524,111 bp
  • A to G, chromosome 6 at 115,774,653 bp
  • T to C, chromosome 6 at 123,823,181 bp
  • T to A, chromosome 6 at 125,626,361 bp
  • A to G, chromosome 6 at 129,093,468 bp
  • T to C, chromosome 7 at 10,388,778 bp
  • C to T, chromosome 7 at 24,104,707 bp
  • A to G, chromosome 7 at 25,621,029 bp
  • G to A, chromosome 7 at 28,403,977 bp
  • A to G, chromosome 7 at 29,145,860 bp
  • T to A, chromosome 7 at 34,151,021 bp
  • T to C, chromosome 7 at 35,281,381 bp
  • T to C, chromosome 7 at 65,314,990 bp
  • A to G, chromosome 7 at 67,251,724 bp
  • T to A, chromosome 7 at 85,233,249 bp
  • C to G, chromosome 7 at 85,233,258 bp
  • G to T, chromosome 7 at 106,330,454 bp
  • T to A, chromosome 7 at 121,131,341 bp
  • A to T, chromosome 8 at 22,128,729 bp
  • C to T, chromosome 8 at 24,674,054 bp
  • T to C, chromosome 8 at 105,091,502 bp
  • C to T, chromosome 8 at 114,706,278 bp
  • A to G, chromosome 9 at 7,451,320 bp
  • T to A, chromosome 9 at 21,991,708 bp
  • G to A, chromosome 9 at 31,349,268 bp
  • A to G, chromosome 9 at 31,388,897 bp
  • T to A, chromosome 9 at 35,020,163 bp
  • A to G, chromosome 9 at 37,422,177 bp
  • A to G, chromosome 9 at 44,201,005 bp
  • A to C, chromosome 9 at 44,298,948 bp
  • T to A, chromosome 9 at 50,621,046 bp
  • A to C, chromosome 9 at 65,001,022 bp
  • T to C, chromosome 9 at 72,452,804 bp
  • A to G, chromosome 9 at 72,844,958 bp
  • T to A, chromosome 9 at 106,885,998 bp
  • G to T, chromosome 9 at 114,629,150 bp
  • T to C, chromosome 10 at 12,710,060 bp
  • A to G, chromosome 10 at 100,508,758 bp
  • T to C, chromosome 10 at 115,174,109 bp
  • T to C, chromosome 10 at 123,007,021 bp
  • T to C, chromosome 11 at 51,988,602 bp
  • A to T, chromosome 11 at 55,310,777 bp
  • A to T, chromosome 11 at 100,699,264 bp
  • A to T, chromosome 12 at 7,988,678 bp
  • C to T, chromosome 12 at 40,214,094 bp
  • G to C, chromosome 12 at 71,975,304 bp
  • A to G, chromosome 12 at 83,133,677 bp
  • T to C, chromosome 12 at 103,601,360 bp
  • C to T, chromosome 12 at 109,591,386 bp
  • T to A, chromosome 13 at 9,158,107 bp
  • T to A, chromosome 13 at 40,015,313 bp
  • T to C, chromosome 13 at 49,662,152 bp
  • T to C, chromosome 13 at 53,337,612 bp
  • T to C, chromosome 13 at 64,210,192 bp
  • T to C, chromosome 13 at 96,088,708 bp
  • A to G, chromosome 14 at 16,418,442 bp
  • G to A, chromosome 14 at 61,205,640 bp
  • T to C, chromosome 14 at 73,178,547 bp
  • G to T, chromosome 15 at 38,030,672 bp
  • A to T, chromosome 15 at 39,086,764 bp
  • A to T, chromosome 15 at 80,003,419 bp
  • T to C, chromosome 15 at 81,640,116 bp
  • A to T, chromosome 15 at 85,066,277 bp
  • T to A, chromosome 15 at 100,193,913 bp
  • T to C, chromosome 15 at 103,453,883 bp
  • C to A, chromosome 16 at 9,579,585 bp
  • A to G, chromosome 16 at 17,650,476 bp
  • T to C, chromosome 16 at 20,541,099 bp
  • A to G, chromosome 16 at 22,081,801 bp
  • G to T, chromosome 16 at 34,875,620 bp
  • A to G, chromosome 16 at 59,149,299 bp
  • A to T, chromosome 16 at 59,622,421 bp
  • A to T, chromosome 17 at 46,528,589 bp
  • A to T, chromosome 18 at 4,169,175 bp
  • A to T, chromosome 18 at 12,407,563 bp
  • C to T, chromosome 18 at 23,597,501 bp
  • C to A, chromosome 18 at 49,879,362 bp
  • T to A, chromosome 18 at 59,075,688 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0390 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038596-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.