Strain Name:
C57BL/6J-MtgxR0486Btlr/Mmmh
Stock Number:
038685-MU
Citation ID:
RRID:MMRRC_038685-MU
Other Names:
R0486 (G1), C57BL/6J-MtgxR0486Btlr
Major Collection:

Gene Information

Yes1
Name: YES proto-oncogene 1, Src family tyrosine kinase
Synonyms: Yes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22612
Homologene: 55900
Arl8b
Name: ADP-ribosylation factor-like 8B
Synonyms: 2610313E07Rik, 3100002J04Rik, Arl10c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67166
Homologene: 10056
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Foxo3
Name: forkhead box O3
Synonyms: Foxo3a, 2010203A17Rik, 1110048B16Rik, Fkhr2, FKHRL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56484
HGNC: HGNC:3821
Homologene: 31039
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: S1, P112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Anln
Name: anillin, actin binding protein
Synonyms: 1110037A17Rik, Scraps, 2900037I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68743
VEGA: 9
Homologene: 41281
G3bp1
Name: GTPase activating protein (SH3 domain) binding protein 1
Synonyms: GAP SH3 binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27041
Homologene: 38096
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 6720416K24Rik, 1110036I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14897
Homologene: 44226
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109331
Homologene: 5571
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CAP-D2, CNAP1, 2810465G24Rik, 2810406C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68298
Homologene: 6497
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Aco1
Name: aconitase 1
Synonyms: Aco-1, Irp1, Irebp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11428
HGNC: HGNC:117
Homologene: 1657
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66585
Homologene: 3538
Rnf165
Name: ring finger protein 165
Synonyms: G630064H08Rik, 2900024M11Rik, Ark2c, LOC225743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225743
Homologene: 79757
Tfap2a
Name: transcription factor AP-2, alpha
Synonyms: AP2alpha, Ap2, Ap-2 (a), AP-2 alpha, Ap2tf, Tcfap2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 21418
VEGA: 13
Homologene: 2421
Nop2
Name: NOP2 nucleolar protein
Synonyms: 120kDa, Nol1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110109
HGNC: HGNC:7867
Homologene: 135865
F11r
Name: F11 receptor
Synonyms: JAM-1, JAM-A, Ly106, Jcam1, BV11 antigen, ESTM33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16456
Homologene: 14255
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Cwf19l1
Name: CWF19-like 1, cell cycle control (S. pombe)
Synonyms: 2610528C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72502
VEGA: 19
Homologene: 41244
Haus8
Name: 4HAUS augmin-like complex, subunit 8
Synonyms: Hice1, 2410004L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76478
Homologene: 12644
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Nhlrc3
Name: NHL repeat containing 3
Synonyms: 8030451K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 212114
Homologene: 35239
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: MINOR, NOR-1, Nor1, TEC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Cyp4f18
Name: cytochrome P450, family 4, subfamily f, polypeptide 18
Synonyms: 1810054N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72054
HGNC: HGNC:2645
Homologene: 128623
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: mdfw, USH1D, ahl, nmf252, nmf181, nmf112, sals, bob, 4930542A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Fastkd2
Name: FAST kinase domains 2
Synonyms: 2810421I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75619
Homologene: 8957
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Piezo2, Fam38b2, Fam38b, 9430028L06Rik, 9030411M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Kdm5d
Name: lysine (K)-specific demethylase 5D
Synonyms: Smcy, HY, Jarid1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 20592
Homologene: 55838
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Birc1b, Naip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218865
Homologene: 41261
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75820
Homologene: 51634
Wdr31
Name: WD repeat domain 31
Synonyms: 5430402I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71354
Homologene: 11360
Arhgef11
Name: Rho guanine nucleotide exchange factor (GEF) 11
Synonyms: Prg, PDZ-RhoGEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213498
Homologene: 11409
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: Rw, B930011P16Rik, Dpp-6, LOC384168, In(5)6H-p, Peplb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Cd101
Name: CD101 antigen
Synonyms: Igsf2, LOC381460
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 630146
HGNC: HGNC:5949
Homologene: 3142
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: 2810043H12Rik, SNM1, SMN1a, mSNM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 55947
Homologene: 8920
Tas2r126
Name: taste receptor, type 2, member 126
Synonyms: T2R26, T2R12, Tas2r26, mGR26, mt2r35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387353
Homologene: 16412
Syce1l
Name: synaptonemal complex central element protein 1 like
Synonyms: 4930481F22Rik, mmrp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 668110
Homologene: 86343
Gbp7
Name: guanylate binding protein 7
Synonyms: 9830147J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229900
Homologene: 138296
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: 4732433M03Rik, CPSase I, CPS, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Glipr1
Name: GLI pathogenesis-related 1 (glioma)
Synonyms: 2410114O14Rik, RTVP-1, mRTVP-1, RTVP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73690
Homologene: 21357
Fam120b
Name: family with sequence similarity 120, member B
Synonyms: CCPG, 4932442K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67544
VEGA: 17
Homologene: 13033
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: MDC2, 2900022I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Pus1
Name: pseudouridine synthase 1
Synonyms: MPUS1, A730013B20Rik, mPus1p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56361
Homologene: 5931
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 104015
Homologene: 48252
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 626596
Homologene: 75047
Foxg1
Name: forkhead box G1
Synonyms: Hfh9, Bf1, Hfhbf1, BF-1, 2900064B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Cmtm2b
Name: CKLF-like MARVEL transmembrane domain containing 2B
Synonyms: 1700013O04Rik, Cklfsf2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75502
Homologene: 88915
Spam1
Name: sperm adhesion molecule 1
Synonyms: Ph-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20690
Homologene: 7547
Olfr881
Name: olfactory receptor 881
Synonyms: GA_x6K02T2PVTD-31676771-31677700, MOR162-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258413
Homologene: 74013
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: D8Ertd82e, NACK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244418
Homologene: 18256
Prpsap2
Name: phosphoribosyl pyrophosphate synthetase-associated protein 2
Synonyms: A230054F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 212627
HGNC: HGNC:9467
Homologene: 2073
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: G6pd1, Gpd-1, Gpd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Kcnj13
Name: potassium inwardly-rectifying channel, subfamily J, member 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040591
HGNC: HGNC:6259
Homologene: 55638
Ptpn7
Name: protein tyrosine phosphatase, non-receptor type 7
Synonyms: C920001D21Rik, LC-PTP, BPTP-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320139
HGNC: HGNC:9659
Homologene: 15411
Ccdc185
Name: coiled-coil domain containing 185
Synonyms: 4922505E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433386
Homologene: 17631
Gm11555
Name: predicted gene 11555
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 546511
BC051665
Name: cDNA sequence BC051665
Synonyms: cathepsin L-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218275
VEGA: 13
Homologene: 74298
Cyp4f17
Name: cytochrome P450, family 4, subfamily f, polypeptide 17
Synonyms: EG208285
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 208285
VEGA: 17
Homologene: 129713
Bloc1s2
Name: biogenesis of lysosomal organelles complex-1, subunit 2
Synonyms: BLOS2, Bloc1s2a, 2410089B13Rik, Bloc1s2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73689
VEGA: 19
Homologene: 45479
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 63,752,340 bp
  • T to C, chromosome 1 at 67,165,392 bp
  • C to A, chromosome 1 at 84,761,084 bp
  • T to A, chromosome 1 at 86,094,290 bp
  • C to A, chromosome 1 at 87,387,030 bp
  • T to A, chromosome 1 at 87,479,126 bp
  • C to T, chromosome 1 at 135,137,358 bp
  • T to A, chromosome 1 at 140,509,480 bp
  • T to C, chromosome 1 at 171,460,588 bp
  • T to C, chromosome 1 at 175,795,203 bp
  • T to G, chromosome 1 at 182,747,859 bp
  • T to C, chromosome 3 at 53,452,437 bp
  • T to A, chromosome 3 at 87,688,852 bp
  • T to C, chromosome 3 at 101,008,092 bp
  • C to A, chromosome 3 at 142,546,317 bp
  • T to C, chromosome 4 at 40,177,783 bp
  • T to C, chromosome 4 at 48,056,525 bp
  • C to A, chromosome 4 at 49,645,907 bp
  • A to G, chromosome 4 at 62,453,893 bp
  • C to G, chromosome 4 at 130,378,043 bp
  • G to A, chromosome 4 at 149,982,936 bp
  • A to T, chromosome 5 at 8,330,048 bp
  • T to C, chromosome 5 at 27,661,642 bp
  • T to A, chromosome 5 at 32,655,582 bp
  • A to T, chromosome 5 at 110,779,730 bp
  • A to T, chromosome 6 at 24,796,395 bp
  • A to T, chromosome 6 at 42,435,291 bp
  • A to T, chromosome 6 at 108,815,326 bp
  • A to G, chromosome 6 at 125,140,673 bp
  • G to A, chromosome 6 at 125,184,027 bp
  • A to T, chromosome 8 at 36,146,633 bp
  • C to A, chromosome 8 at 71,256,537 bp
  • C to T, chromosome 8 at 71,256,538 bp
  • C to A, chromosome 8 at 71,996,017 bp
  • A to T, chromosome 8 at 104,330,415 bp
  • A to T, chromosome 8 at 113,654,763 bp
  • T to C, chromosome 9 at 22,352,826 bp
  • A to G, chromosome 9 at 37,992,702 bp
  • A to G, chromosome 10 at 42,197,481 bp
  • C to A, chromosome 10 at 60,386,946 bp
  • T to C, chromosome 10 at 111,996,849 bp
  • T to C, chromosome 11 at 55,498,626 bp
  • A to G, chromosome 11 at 61,741,000 bp
  • A to G, chromosome 11 at 99,650,160 bp
  • T to C, chromosome 12 at 49,384,531 bp
  • G to A, chromosome 12 at 110,896,369 bp
  • G to T, chromosome 13 at 40,728,694 bp
  • C to T, chromosome 13 at 60,784,045 bp
  • A to C, chromosome 13 at 100,161,782 bp
  • T to C, chromosome 14 at 30,032,858 bp
  • C to T, chromosome 14 at 56,514,175 bp
  • A to T, chromosome 15 at 8,338,870 bp
  • A to G, chromosome 15 at 36,092,882 bp
  • T to C, chromosome 16 at 90,938,263 bp
  • C to T, chromosome 17 at 15,426,288 bp
  • G to A, chromosome 17 at 15,734,342 bp
  • T to C, chromosome 17 at 32,524,823 bp
  • A to C, chromosome 18 at 63,029,061 bp
  • T to A, chromosome 18 at 77,484,254 bp
  • A to G, chromosome 19 at 44,114,690 bp
  • A to G, chromosome 19 at 44,143,150 bp
  • A to G, chromosome 19 at 56,541,490 bp
  • A to G, chromosome Y at 927,107 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0486 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038685-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.