Strain Name:
C57BL/6J-MtgxR0490Btlr/Mmmh
Stock Number:
038688-MU
Citation ID:
RRID:MMRRC_038688-MU
Other Names:
R0490 (G1), C57BL/6J-MtgxR0490Btlr
Major Collection:

Gene Information

Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Synonyms: Kir4.1, BIRK-1, BIR10, Kir1.2, Kir4.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16513
HGNC: HGNC:6256
Homologene: 1689
Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CDO, CAM-related/down-regulated by oncogenes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57810
Homologene: 22996
Gsr
Name: glutathione reductase
Synonyms: Gr-1, Gr1, D8Ertd238e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14782
HGNC: HGNC:4623
Homologene: 531
Dst
Name: dystonin
Synonyms: Macf2, Bpag, athetoid, bullous pemphigoid antigen 1, nmf339, 2310001O04Rik, nmf203, A830042E19Rik, ah, Bpag1, BPAG1, BPAG1-n, bullous pemphigoid antigen 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: 2610204M12Rik, Mcaf1, AM, ATFa-associated Modulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54343
Homologene: 10051
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 404710
Homologene: 26400
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Lpl
Name: lipoprotein lipase
Synonyms: O 1-4-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16956
HGNC: HGNC:6677
Homologene: 200
Lnx1
Name: ligand of numb-protein X 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16924
HGNC: HGNC:6657
Homologene: 7819
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Dnahc8, P1-Loop, Hst6.7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Zswim1
Name: zinc finger SWIM-type containing 1
Synonyms: 2410003H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71971
Homologene: 12429
Gipc2
Name: GIPC PDZ domain containing family, member 2
Synonyms: Semcap2, 2200002N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54120
Homologene: 22994
Ank1
Name: ankyrin 1, erythroid
Synonyms: pale, Ank-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Epha5
Name: Eph receptor A5
Synonyms: Ehk1, Cek7, bsk, Rek7, Hek7, Els1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Rpgrip1l
Name: Rpgrip1-like
Synonyms: fantom, Nphp8, 1700047E16Rik, Ftm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244585
Homologene: 18296
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Slc1a1
Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Synonyms: EAAT3, D130048G10Rik, MEAAC1, EAAC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20510
Homologene: 20881
Adamts9
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
Synonyms: E030027K14Rik, UND3, Gsfund3, 1810011L16Rik, UND4, 8430403M15Rik, Mhdaund4, Mhdaund3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101401
Homologene: 18821
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Prkch
Name: protein kinase C, eta
Synonyms: Pkch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18755
HGNC: HGNC:9403
Homologene: 84384
Ccdc81
Name: coiled-coil domain containing 81
Synonyms: 4921513D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70884
Homologene: 128447
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, 1110001D15Rik, Vwa6, EG235580
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Pigs
Name: phosphatidylinositol glycan anchor biosynthesis, class S
Synonyms: LOC276846, LOC245087
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276846
Homologene: 41963
Pcdhb8
Name: protocadherin beta 8
Synonyms: PcdhbH, Pcdhb5C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93879
Homologene: 89038
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381260
Homologene: 124277
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74362
Homologene: 52601
Gtdc1
Name: glycosyltransferase-like domain containing 1
Synonyms: E330008O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227835
Homologene: 32590
Notch4
Name: notch 4
Synonyms: Int3, N4, Int-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Als2cl
Name: ALS2 C-terminal like
Synonyms: mRn.49018, D930044G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235633
Homologene: 17152
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381352
Homologene: 17102
Bean1
Name: brain expressed, associated with Nedd4, 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 65115
Homologene: 110172
Nek8
Name: NIMA (never in mitosis gene a)-related expressed kinase 8
Synonyms: 4632401F23Rik, b2b1449Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 140859
Homologene: 84442
Zfp948
Name: zinc finger protein 948
Synonyms: BC049807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381066
VEGA: 17
Hsdl2
Name: hydroxysteroid dehydrogenase like 2
Synonyms: 2610207I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72479
Olfr1499
Name: olfactory receptor 1499
Synonyms: MOR211-2, GA_x6K02T2RE5P-4147744-4146800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258792
Homologene: 17393
Mogat2
Name: monoacylglycerol O-acyltransferase 2
Synonyms: DGAT2L5, Mgat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233549
Homologene: 57020
9330159F19Rik
Name: RIKEN cDNA 9330159F19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212448
VEGA: 10
Homologene: 8804
Trim15
Name: tripartite motif-containing 15
Synonyms: 1810012B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69097
Homologene: 23819
Cd48
Name: CD48 antigen
Synonyms: BCM1, Bcm-1, Sgp-60, BLAST-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12506
HGNC: HGNC:1683
Homologene: 1347
Rita1
Name: RBPJ interacting and tubulin associated 1
Synonyms: 1110008J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100764
Homologene: 12585
Cers3
Name: ceramide synthase 3
Synonyms: CerS3, T3L, 4930550L11Rik, Lass3, related to TRH3, LOC233330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545975
Homologene: 18719
Zfy2
Name: zinc finger protein 2, Y-linked
Synonyms: Zfy-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22768
Homologene: 56456
Olfr1475
Name: olfactory receptor 1475
Synonyms: MOR202-36, GA_x6K02T2RE5P-3812807-3811863
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258298
Homologene: 77370
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Tas2r116
Name: taste receptor, type 2, member 116
Synonyms: Tas2r16, TRB1, TRB4, Tas2r7, mt2r56, T2R16, mGR16, Tas2r14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 112408
Homologene: 130070
Gng8
Name: guanine nucleotide binding protein (G protein), gamma 8
Synonyms: G(y)8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14709
Homologene: 7740
Olfr1373
Name: olfactory receptor 1373
Synonyms: GA_x6K02T2QP88-3283154-3284089, MOR256-69_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 211472
Homologene: 72463
AC166823.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Gsdmc3
Name: gasdermin C3
Synonyms: 9930109F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 270328
HGNC: HGNC:7151
Homologene: 69487
Dvl3
Name: dishevelled segment polarity protein 3
Synonyms: b2b2866Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13544
HGNC: HGNC:3087
Homologene: 20928
Olfr1457
Name: olfactory receptor 1457
Synonyms: GA_x6K02T2RE5P-3423041-3422097, MOR202-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258568
Homologene: 133676
Fxn
Name: frataxin
Synonyms: Frda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14297
HGNC: HGNC:3951
Homologene: 47908
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 34,307,368 bp
  • C to T, chromosome 1 at 59,558,234 bp
  • A to G, chromosome 1 at 171,704,877 bp
  • A to G, chromosome 1 at 172,369,452 bp
  • C to T, chromosome 2 at 25,563,581 bp
  • A to T, chromosome 2 at 44,635,040 bp
  • T to A, chromosome 2 at 76,708,830 bp
  • C to T, chromosome 2 at 76,747,532 bp
  • T to A, chromosome 2 at 127,046,186 bp
  • T to A, chromosome 2 at 164,825,283 bp
  • T to A, chromosome 2 at 180,180,169 bp
  • T to C, chromosome 3 at 88,114,056 bp
  • C to T, chromosome 3 at 99,982,411 bp
  • T to C, chromosome 3 at 103,886,179 bp
  • A to G, chromosome 3 at 152,102,654 bp
  • C to T, chromosome 4 at 59,612,814 bp
  • G to T, chromosome 5 at 41,821,892 bp
  • T to A, chromosome 5 at 74,620,347 bp
  • G to T, chromosome 5 at 84,107,974 bp
  • A to T, chromosome 5 at 120,611,565 bp
  • T to A, chromosome 6 at 92,872,866 bp
  • T to C, chromosome 6 at 104,833,918 bp
  • T to C, chromosome 6 at 132,856,021 bp
  • G to T, chromosome 6 at 136,609,192 bp
  • A to G, chromosome 7 at 16,894,983 bp
  • A to G, chromosome 7 at 66,773,690 bp
  • A to T, chromosome 7 at 89,887,762 bp
  • T to C, chromosome 7 at 99,223,144 bp
  • C to A, chromosome 8 at 23,107,874 bp
  • T to A, chromosome 8 at 33,671,512 bp
  • A to G, chromosome 8 at 68,896,691 bp
  • A to T, chromosome 8 at 91,299,845 bp
  • A to T, chromosome 8 at 104,215,028 bp
  • C to A, chromosome 9 at 35,452,682 bp
  • A to G, chromosome 9 at 66,484,999 bp
  • G to A, chromosome 9 at 106,013,770 bp
  • A to G, chromosome 9 at 110,895,346 bp
  • T to A, chromosome 10 at 29,227,342 bp
  • A to G, chromosome 11 at 52,144,666 bp
  • T to A, chromosome 11 at 78,167,729 bp
  • T to C, chromosome 11 at 78,335,625 bp
  • G to A, chromosome 12 at 64,472,887 bp
  • A to G, chromosome 12 at 73,759,676 bp
  • C to A, chromosome 14 at 52,744,550 bp
  • C to T, chromosome 15 at 63,860,250 bp
  • C to T, chromosome 16 at 20,527,423 bp
  • T to C, chromosome 17 at 21,588,034 bp
  • T to C, chromosome 17 at 30,700,419 bp
  • T to A, chromosome 17 at 34,582,890 bp
  • T to C, chromosome 17 at 36,866,355 bp
  • T to C, chromosome 18 at 37,356,780 bp
  • A to G, chromosome 19 at 13,094,812 bp
  • G to A, chromosome 19 at 13,479,493 bp
  • A to G, chromosome 19 at 13,814,855 bp
  • A to G, chromosome 19 at 24,277,179 bp
  • A to G, chromosome 19 at 28,897,531 bp
  • A to T, chromosome Y at 2,106,620 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0490 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038688-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.