Strain Name:
C57BL/6J-MtgxR0515Btlr/Mmmh
Stock Number:
038709-MU
Citation ID:
RRID:MMRRC_038709-MU
Other Names:
R0515 (G1), C57BL/6J-MtgxR0515Btlr
Major Collection:

Gene Information

App
Name: amyloid beta (A4) precursor protein
Synonyms: Adap, Abeta, appican, betaAPP, E030013M08Rik, Cvap, protease nexin II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11820
VEGA: 16
HGNC: HGNC:620
Homologene: 56379
Gtf2i
Name: general transcription factor II I
Synonyms: 6030441I21Rik, TFII-I, BAP-135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 78757
VEGA: 15
Homologene: 34317
Cltc
Name: clathrin, heavy polypeptide (Hc)
Synonyms: CHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: Depdc2, 6230420N16Rik, C030045D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109294
Homologene: 23523
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: 2900041G10Rik, AATYK2, KPI-2, cprk, KPI2, A330101P12Rik, BREK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231876
Homologene: 8948
Hvcn1
Name: hydrogen voltage-gated channel 1
Synonyms: 0610039P13Rik, BTS, mVSOP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74096
Homologene: 12535
Dennd4c
Name: DENN/MADD domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329877
Homologene: 23057
Dcp2
Name: decapping mRNA 2
Synonyms: 2410015D23Rik, 5730537H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 70640
Homologene: 13968
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: Adprtl1, VPARP, C030027K23Rik, E230037B21Rik, VAULT3, PH5P, p193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Sema6A-1, sema, A730020P05Rik, VIa, Semaq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20358
Homologene: 32426
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: mSiglec-F, Siglec5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233186
Homologene: 50482
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: ECaC1, CaT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: Gm1027, LOC381538, Heatr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381538
Homologene: 19633
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244646
Homologene: 14627
Olfr1500
Name: olfactory receptor 1500
Synonyms: MOR212-4P, GA_x6K02T2RE5P-4160554-4159619
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258097
Homologene: 72644
4930402H24Rik
Name: RIKEN cDNA 4930402H24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228602
Homologene: 12623
Arhgef38
Name: Rho guanine nucleotide exchange factor (GEF) 38
Synonyms: 9130221D24Rik, D630013G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 77669
Homologene: 137396
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74978
Homologene: 46007
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: Sdccag33, NY-CO-33, teashirt1, Tsh1, 5730407I04Rik, D18Bwg1409e, Mtsh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 110796
Homologene: 4227
Gm11360
Name: predicted gene 11360
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 100041036
Slco1b2
Name: solute carrier organic anion transporter family, member 1b2
Synonyms: Slc21a6, 7330442B20Rik, mlst-1, Oatp1b2, Slc21a10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 28253
Homologene: 75119
Prl8a8
Name: prolactin family 8, subfamily a, member 81
Synonyms: PLP-Cgamma, Prlpc3, 1600032B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 74188
Homologene: 137338
Cd96
Name: CD96 antigen
Synonyms: Tactile, 1700109I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 84544
Homologene: 68489
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: LOC384050, C130004B06Rik, 1110020C03Rik, Wdr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68625
Homologene: 51350
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 104015
Homologene: 48252
Mapk8ip1
Name: mitogen-activated protein kinase 8 interacting protein 1
Synonyms: Skip, IB1, mjip-2a, Prkm8ip, MAPK8IP1, Jip1, JIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19099
HGNC: HGNC:6882
Homologene: 31314
Tent5b
Name: terminal nucleotidyltransferase 5B
Synonyms: Fam46b, 4732473B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100342
Homologene: 24928
Olfr889
Name: olfactory receptor 889
Synonyms: MOR162-2, GA_x6K02T2PVTD-31795028-31795957
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258475
Homologene: 138311
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228482
Homologene: 8862
Mill1
Name: MHC I like leukocyte 1
Synonyms: 5530400I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 266815
Homologene: 105329
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: 4933405P16Rik, Als2cr12, 4933425F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108812
Homologene: 51399
Sox13
Name: SRY (sex determining region Y)-box 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20668
Homologene: 4159
Cyp3a41a
Name: cytochrome P450, family 3, subfamily a, polypeptide 41A
Synonyms: Cyp3a41, steroid inducible
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 53973
HGNC: HGNC:2638
Homologene: 133568
Klk1b5
Name: kallikrein 1-related peptidase b5
Synonyms: mGK-5, Klk5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16622
HGNC: HGNC:6364
Homologene: 68141
Nfe2
Name: nuclear factor, erythroid derived 2
Synonyms: p45, p45nf-e2, p45NFE2, NF-E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18022
HGNC: HGNC:7780
Homologene: 4491
Gpank1
Name: G patch domain and ankyrin repeats 1
Synonyms: G5, Bat4, D17H6S54E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 81845
Homologene: 13035
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 11,199,874 bp
  • A to G, chromosome 1 at 58,659,113 bp
  • A to T, chromosome 1 at 133,383,719 bp
  • A to T, chromosome 2 at 92,387,356 bp
  • G to A, chromosome 2 at 113,837,471 bp
  • A to G, chromosome 2 at 130,740,488 bp
  • T to G, chromosome 3 at 133,149,540 bp
  • T to C, chromosome 4 at 86,813,466 bp
  • T to A, chromosome 4 at 106,691,664 bp
  • A to G, chromosome 4 at 118,620,402 bp
  • A to T, chromosome 4 at 133,486,139 bp
  • A to G, chromosome 5 at 122,233,519 bp
  • C to A, chromosome 5 at 134,242,919 bp
  • A to G, chromosome 5 at 144,174,991 bp
  • A to T, chromosome 5 at 145,718,000 bp
  • T to A, chromosome 6 at 41,674,211 bp
  • T to C, chromosome 6 at 141,669,410 bp
  • T to C, chromosome 7 at 18,264,873 bp
  • T to C, chromosome 7 at 43,355,631 bp
  • A to G, chromosome 7 at 44,218,533 bp
  • C to G, chromosome 8 at 109,623,649 bp
  • T to C, chromosome 9 at 38,116,017 bp
  • A to T, chromosome 10 at 103,068,968 bp
  • A to G, chromosome 11 at 86,709,039 bp
  • T to A, chromosome 13 at 27,508,367 bp
  • T to A, chromosome 13 at 27,956,160 bp
  • T to C, chromosome 14 at 56,613,667 bp
  • C to T, chromosome 15 at 6,769,301 bp
  • T to A, chromosome 15 at 103,249,427 bp
  • A to G, chromosome 16 at 46,063,905 bp
  • C to T, chromosome 16 at 85,103,344 bp
  • C to T, chromosome 16 at 90,994,022 bp
  • G to T, chromosome 17 at 35,123,499 bp
  • C to T, chromosome 18 at 44,399,731 bp
  • G to A, chromosome 18 at 47,290,045 bp
  • A to G, chromosome 18 at 84,015,965 bp
  • T to C, chromosome 19 at 13,827,821 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0515 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038709-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.