Strain Name:
C57BL/6J-MtgxR0517Btlr/Mmmh
Stock Number:
038710-MU
Citation ID:
RRID:MMRRC_038710-MU
Other Names:
R0517 (G1), C57BL/6J-MtgxR0517Btlr
Major Collection:

Gene Information

Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms: Xrcc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22594
Homologene: 31368
Mapk1
Name: mitogen-activated protein kinase 1
Synonyms: p42mapk, MAPK2, Prkm1, Erk2, 9030612K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26413
HGNC: HGNC:6871
Homologene: 37670
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218693
Homologene: 4709
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain II-B, NMHC-B, SMemb, nonmuscle myosin heavy chain IIB, 9330167F11Rik, 5730504C04Rik, Myhn2, Myosin IIB, NMHC II-B, Myhn-2, myosin IIB, Fltn, Fltn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Dhx9
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Synonyms: leukophysin, nuclear DNA helicase II, RNA helicase, Ddx9, NDH II, NDHII, RHA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Trappc12
Name: trafficking protein particle complex 12
Synonyms: CGI-87, D930014A20Rik, Ttc15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217449
VEGA: 12
Homologene: 34805
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A930009A08Rik, Gpr48, A330106J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107515
Homologene: 10226
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 1600013L13Rik, 4930541M15Rik, Camsap1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67886
Homologene: 18927
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207932
Homologene: 45941
Slc44a1
Name: solute carrier family 44, member 1
Synonyms: CHTL1, CTL1, 4833416H08Rik, Cdw92, 2210409B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100434
Homologene: 11137
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Rbm15
Name: RNA binding motif protein 15
Synonyms: C230088J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229700
Homologene: 23383
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: VIa, sema, Sema6A-1, Semaq, A730020P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20358
Homologene: 32426
Mpzl1
Name: myelin protein zero-like 1
Synonyms: 1110007A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68481
HGNC: HGNC:7226
Homologene: 2939
Tars
Name: threonyl-tRNA synthetase
Synonyms: ThrRS, D15Wsu59e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110960
VEGA: 15
Homologene: 11852
Pros1
Name: protein S (alpha)
Synonyms: protein S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19128
HGNC: HGNC:9456
Homologene: 264
Tox4
Name: TOX high mobility group box family member 4
Synonyms: 5730589K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268741
Homologene: 8889
Supt3
Name: SPT3, SAGA and STAGA complex component
Synonyms: SPT3L, SPT3, 2310066G22Rik, Supt3h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 109115
Homologene: 121570
Glis2
Name: GLIS family zinc finger 2
Synonyms: Nkl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 83396
Homologene: 12821
Fbxo46
Name: F-box protein 46
Synonyms: 4932704E22Rik, 20D7-FC4, Fbxo34l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243867
Homologene: 18467
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20265
Homologene: 21375
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Exph5
Name: exophilin 5
Synonyms: slac2-b, B130009M24Rik, AC079869.22gm5, Slac2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320051
Homologene: 9007
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: D-LTCC, Cchl1a, Cchl1a2, Cacnl1a2, 8430418G19Rik, Cav1.3alpha1, C79217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Adamts7
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Acer1
Name: alkaline ceramidase 1
Synonyms: 2310024P18Rik, Cer1, Asah3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171168
VEGA: 17
Homologene: 15853
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Eps8l3
Name: EPS8-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99662
Homologene: 15878
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: 4930463I21Rik, Armc4, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Ubqlnl
Name: ubiquilin-like
Synonyms: LOC244179, 4922504M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244179
Homologene: 17034
Spata46
Name: spermatogenesis associated 46
Synonyms: 1700015E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76925
Homologene: 18799
Adamts1
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Synonyms: ADAM-TS1, METH1, METH-1, ADAMTS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Ceacam15
Name: CEA cell adhesion molecule 15
Synonyms: C430002N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101434
Homologene: 131210
Or13p8
Name: olfactory receptor family 13 subfamily P member 8
Synonyms: GA_x6K02T2QD9B-18823451-18822504, MOR258-6, Olfr1340
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258301
Homologene: 122779
Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms: 2210009K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72303
Homologene: 133566
Adcyap1r1
Name: adenylate cyclase activating polypeptide 1 receptor 1
Synonyms: PACAP1-R, PAC1, PAC1R, 2900024I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11517
HGNC: HGNC:242
Homologene: 870
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224916
Sgsm2
Name: small G protein signaling modulator 2
Synonyms: D630003G22Rik, Rutbc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 97761
Homologene: 14780
Cerk
Name: ceramide kinase
Synonyms: D330016D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223753
Homologene: 11247
Fgf14
Name: fibroblast growth factor 14
Synonyms: Fhf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14169
HGNC: HGNC:3671
Homologene: 3037
Mpp4
Name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Synonyms: DLG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227157
Homologene: 23296
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Or5m9
Name: olfactory receptor family 5 subfamily M member 9
Synonyms: MOR227-8P, GA_x6K02T2Q125-47521463-47522395, MOR227-8P, MOR245-14P, Olfr1533-ps1, Olfr1034
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258216
Homologene: 51741
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: 4932701A20Rik, Hyal-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Cyp27b1
Name: cytochrome P450, family 27, subfamily b, polypeptide 1
Synonyms: 1alpha(OH)ase, P450VD1alpha, 25-hydroxyvitamin D3 1alpha-hydroxylase, 25(OH)D 1alpha-hydroxylase, Pddr, Cyp1, VddrI, P450c1, Cyp27b, Vddr, Vdd1, Cp2b, Cyp40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13115
HGNC: HGNC:2606
Homologene: 37139
Asic5
Name: acid-sensing (proton-gated) ion channel family member 5
Synonyms: brain-liver-intestine amiloride-sensitive sodium channel, BLINaC, Accn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 58170
Homologene: 41171
Mpg
Name: N-methylpurine-DNA glycosylase
Synonyms: Mid1, Aag, 3-methyladenine DNA glycosylase, alkylpurine-DNA-N-glycosylase, APNG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268395
HGNC: HGNC:7211
Homologene: 1824
Dpysl5
Name: dihydropyrimidinase-like 5
Synonyms: Crmp5, CRMP-5, CRAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 65254
Homologene: 41347
Tas2r139
Name: taste receptor, type 2, member 139
Synonyms: mt2r34, Tas2r39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353148
Homologene: 52214
Vmn1r49
Name: vomeronasal 1, receptor 49
Synonyms: VRi2, V1r5, V1rb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 24112
Homologene: 113975
Pira2
Name: paired-Ig-like receptor A2
Synonyms: 6M23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18725
Homologene: 134028
Tc2n
Name: tandem C2 domains, nuclear
Synonyms: 4933406D09Rik, Tac2-N, Mtac2d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74413
Homologene: 12560
Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Synonyms: PI5, Spi1-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20704
HGNC: HGNC:8941
Homologene: 20103
Gm10000
Name: predicted gene 10000
Synonyms: Gm10000, DIGIT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 791311
VEGA: 12
Foxf2
Name: forkhead box F2
Synonyms: FREAC2, Fkh20, LUN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14238
HGNC: HGNC:3810
Homologene: 1115
2410137M14Rik
Name: RIKEN cDNA 2410137M14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76797
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 59,124,727 bp
  • G to T, chromosome 1 at 136,293,388 bp
  • C to T, chromosome 1 at 153,478,916 bp
  • T to C, chromosome 1 at 165,601,790 bp
  • A to G, chromosome 1 at 170,311,609 bp
  • T to G, chromosome 2 at 29,157,133 bp
  • T to G, chromosome 2 at 58,035,373 bp
  • T to A, chromosome 2 at 66,302,407 bp
  • T to C, chromosome 2 at 86,047,204 bp
  • T to C, chromosome 2 at 110,011,320 bp
  • A to G, chromosome 2 at 181,227,770 bp
  • A to T, chromosome 3 at 82,009,526 bp
  • A to T, chromosome 3 at 107,331,369 bp
  • T to C, chromosome 3 at 107,883,460 bp
  • T to C, chromosome 4 at 53,542,366 bp
  • T to A, chromosome 4 at 118,726,634 bp
  • A to G, chromosome 4 at 139,392,124 bp
  • A to G, chromosome 5 at 30,778,066 bp
  • A to G, chromosome 6 at 24,734,853 bp
  • A to C, chromosome 6 at 42,141,491 bp
  • T to A, chromosome 6 at 55,491,297 bp
  • A to G, chromosome 6 at 90,072,738 bp
  • A to T, chromosome 6 at 141,498,657 bp
  • A to T, chromosome 7 at 3,844,197 bp
  • A to C, chromosome 7 at 16,673,520 bp
  • A to G, chromosome 7 at 19,136,874 bp
  • C to T, chromosome 7 at 24,570,319 bp
  • G to T, chromosome 7 at 104,148,638 bp
  • A to G, chromosome 7 at 109,934,761 bp
  • A to G, chromosome 9 at 53,372,762 bp
  • T to C, chromosome 9 at 90,199,858 bp
  • T to C, chromosome 10 at 127,050,116 bp
  • A to T, chromosome 11 at 32,231,853 bp
  • A to G, chromosome 11 at 68,811,599 bp
  • G to T, chromosome 11 at 74,867,651 bp
  • T to C, chromosome 12 at 28,697,134 bp
  • C to T, chromosome 12 at 101,649,195 bp
  • G to A, chromosome 12 at 103,949,227 bp
  • T to G, chromosome 12 at 104,476,408 bp
  • T to A, chromosome 13 at 3,566,964 bp
  • C to T, chromosome 13 at 31,626,243 bp
  • T to A, chromosome 13 at 119,447,790 bp
  • A to T, chromosome 14 at 30,179,275 bp
  • A to T, chromosome 14 at 52,292,628 bp
  • G to A, chromosome 14 at 123,983,784 bp
  • T to A, chromosome 15 at 11,394,366 bp
  • G to A, chromosome 15 at 86,156,648 bp
  • T to C, chromosome 16 at 4,611,552 bp
  • A to T, chromosome 16 at 17,016,046 bp
  • A to G, chromosome 16 at 62,903,518 bp
  • C to A, chromosome 16 at 85,800,353 bp
  • G to A, chromosome 16 at 90,777,422 bp
  • T to A, chromosome 17 at 36,981,132 bp
  • T to C, chromosome 17 at 45,119,271 bp
  • T to C, chromosome 17 at 56,955,569 bp
  • T to C, chromosome 17 at 57,508,949 bp
  • A to C, chromosome 18 at 7,223,621 bp
  • A to G, chromosome 18 at 20,529,025 bp
  • G to A, chromosome 18 at 47,290,045 bp
  • T to C, chromosome 19 at 39,082,348 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0517 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038710-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.