Strain Name:
C57BL/6J-MtgxR0548Btlr/Mmmh
Stock Number:
038740-MU
Citation ID:
RRID:MMRRC_038740-MU
Other Names:
R0548 (G1), C57BL/6J-MtgxR0548Btlr
Major Collection:

Gene Information

Fiz1
Name: Flt3 interacting zinc finger protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23877
Homologene: 22663
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap5, LC1, MAP5, Mtap-5, Mtap1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Maco1
Name: macoilin 1
Synonyms: Tmem57, 9230118A01Rik, 1110007C24Rik, C61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66146
Homologene: 14449
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: 6720401E04Rik, NuMA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20133
Homologene: 806
Rrp15
Name: ribosomal RNA processing 15 homolog (S. cerevisiae)
Synonyms: 5430437H21Rik, 2810430M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67223
Homologene: 32293
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: 2610024N01Rik, Tarsl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71807
Homologene: 23520
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: an, 2900018K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214444
Homologene: 49533
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, Ki67, D630048A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Agfg1
Name: ArfGAP with FG repeats 1
Synonyms: Hrb, D730048C23Rik, Rip, C130049H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15463
HGNC: HGNC:5175
Homologene: 37929
Mphosph10
Name: M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
Synonyms: 2810453H10Rik, 5730405D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67973
HGNC: HGNC:7213
Homologene: 134741
N4bp2
Name: NEDD4 binding protein 2
Synonyms: LOC386488, B3bp, LOC333789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333789
Homologene: 32396
Epm2aip1
Name: EPM2A (laforin) interacting protein 1
Synonyms: A930003G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77781
Homologene: 8875
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, Rw1, D1Bwg0491e, YR-23, 2610524E03Rik, Neg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56030
Homologene: 32428
Nsd2
Name: nuclear receptor binding SET domain protein 2
Synonyms: 9430010A17Rik, 5830445G22Rik, Whsc1l, D930023B08Rik, C130020C13Rik, D030027O06Rik, Whsc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 107823
Homologene: 26175
Htt
Name: huntingtin
Synonyms: htt, HD, C430023I11Rik, Hdh, huntingtin, IT15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Tln1
Name: talin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21894
Homologene: 21267
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Fam72a
Name: family with sequence similarity 72, member A
Synonyms: P17, 2700049P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108900
Homologene: 82352
Asxl3
Name: additional sex combs like 3, transcriptional regulator
Synonyms: C230079D11Rik, LOC381127, D430002O22Rik, D930044O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211961
Homologene: 19371
Lct
Name: lactase
Synonyms: Lphl, LOC226413, LPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Enam
Name: enamelin
Synonyms: abte
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13801
HGNC: HGNC:3344
Homologene: 9698
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269959
Homologene: 18912
Marco
Name: macrophage receptor with collagenous structure
Synonyms: Scara2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17167
HGNC: HGNC:6895
Homologene: 4928
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232875
Homologene: 122136
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: Cmya3, mXin beta, myomaxin, 2310003D02Rik, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: Heatr7b1, OTTMUSG00000020804, ENSMUSG00000044873
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434341
Homologene: 88935
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: testase 9, 1700056P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Serping1
Name: serine (or cysteine) peptidase inhibitor, clade G, member 1
Synonyms: C1INH, C1nh, C1 inhibitor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12258
HGNC: HGNC:1228
Homologene: 44
Olfr1225
Name: olfactory receptor 1225
Synonyms: MOR233-11, GA_x6K02T2Q125-50650037-50649102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258893
Homologene: 17427
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mar, Mor1, Mart1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74521
Homologene: 12571
Postn
Name: periostin, osteoblast specific factor
Synonyms: peri, A630052E07Rik, Periostin, Osf2, OSF-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 50706
Homologene: 4730
Mylk
Name: myosin, light polypeptide kinase
Synonyms: MLCK108, nmMlck, MLCK210, Mlck, 9530072E15Rik, telokin, A930019C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Olfr144
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Mmp15
Name: matrix metallopeptidase 15
Synonyms: MT2-MMP, Membrane type 2-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17388
HGNC: HGNC:7161
Homologene: 20549
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: Esdn, 1700055P21Rik, CLCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73379
Homologene: 12499
Gm7589
Name: predicted gene 7589
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665330
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218441
Homologene: 8826
Tmem232
Name: transmembrane protein 232
Synonyms: E130009J12Rik, LOC381107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: G6pd1, Gpd-1, Gpd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Padi4
Name: peptidyl arginine deiminase, type IV
Synonyms: PAD type IV, Pad4, Pdi4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18602
Homologene: 7883
Rxrg
Name: retinoid X receptor gamma
Synonyms: Nr2b3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20183
Homologene: 21373
Wdr20rt
Name: WD repeat domain 20, retrogene
Synonyms: Wdr20b, 4921538B03Rik, 4930427E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70948
VEGA: 12
Vmn1r7
Name: vomeronasal 1 receptor 7
Synonyms: V1rc31, Gm5568
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434016
Homologene: 83427
Car5b
Name: carbonic anhydrase 5b, mitochondrial
Synonyms: 7330410H16Rik, D730005F19Rik, CAVB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 56078
HGNC: HGNC:1378
Homologene: 21413
RP23-208E23.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm10355
Name: predicted gene 10355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100043490
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68274
Homologene: 130753
Smo
Name: smoothened, frizzled class receptor
Synonyms: E130215L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319757
Homologene: 4115
Olfr437
Name: olfactory receptor 437
Synonyms: MOR261-11, GA_x6K02T2P3E9-4391088-4390156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258293
Homologene: 122778
Ankrd37
Name: ankyrin repeat domain 37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 654824
Homologene: 35347
Cox10
Name: heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
Synonyms: 2410004F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70383
HGNC: HGNC:2260
Homologene: 80170
Gm11595
Name: predicted gene 11595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Il33
Name: interleukin 33
Synonyms: NF-HEV, 9230117N10Rik, Il-33, Il1f11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 77125
Homologene: 14126
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,838,038 bp
  • A to G, chromosome 1 at 82,886,431 bp
  • C to A, chromosome 1 at 88,242,420 bp
  • T to C, chromosome 1 at 120,492,038 bp
  • T to C, chromosome 1 at 128,285,195 bp
  • T to A, chromosome 1 at 131,533,861 bp
  • T to C, chromosome 1 at 167,631,219 bp
  • A to G, chromosome 1 at 186,736,234 bp
  • C to T, chromosome 2 at 67,514,414 bp
  • G to A, chromosome 2 at 69,537,638 bp
  • T to C, chromosome 2 at 84,770,081 bp
  • C to A, chromosome 2 at 89,170,648 bp
  • T to C, chromosome 2 at 112,335,924 bp
  • A to G, chromosome 2 at 180,197,030 bp
  • C to A, chromosome 3 at 54,367,576 bp
  • T to C, chromosome 3 at 95,742,659 bp
  • C to T, chromosome 3 at 101,307,060 bp
  • T to C, chromosome 4 at 43,542,709 bp
  • G to A, chromosome 4 at 52,612,140 bp
  • A to T, chromosome 4 at 70,349,142 bp
  • T to C, chromosome 4 at 134,806,660 bp
  • GCTGCGTACCTCCAC to GC, chromosome 4 at 140,748,449 bp
  • A to T, chromosome 4 at 149,981,616 bp
  • T to A, chromosome 5 at 33,893,538 bp
  • T to C, chromosome 5 at 34,870,746 bp
  • G to T, chromosome 5 at 65,808,153 bp
  • A to T, chromosome 5 at 88,503,105 bp
  • C to A, chromosome 5 at 150,544,935 bp
  • A to T, chromosome 6 at 29,759,586 bp
  • A to T, chromosome 6 at 32,158,015 bp
  • T to A, chromosome 6 at 43,167,187 bp
  • A to T, chromosome 6 at 57,025,081 bp
  • A to T, chromosome 7 at 5,009,168 bp
  • G to T, chromosome 7 at 12,774,176 bp
  • T to A, chromosome 7 at 64,378,800 bp
  • T to C, chromosome 7 at 82,528,983 bp
  • T to C, chromosome 7 at 101,995,524 bp
  • G to T, chromosome 7 at 102,467,067 bp
  • T to A, chromosome 7 at 135,695,256 bp
  • A to T, chromosome 7 at 135,696,908 bp
  • T to G, chromosome 8 at 40,826,467 bp
  • C to T, chromosome 8 at 45,998,396 bp
  • C to A, chromosome 8 at 94,521,783 bp
  • T to C, chromosome 8 at 95,372,351 bp
  • A to T, chromosome 9 at 39,238,371 bp
  • T to G, chromosome 9 at 59,146,156 bp
  • T to C, chromosome 9 at 111,273,341 bp
  • T to C, chromosome 9 at 119,665,928 bp
  • A to T, chromosome 11 at 63,976,352 bp
  • T to C, chromosome 11 at 83,982,188 bp
  • A to T, chromosome 11 at 99,772,141 bp
  • A to T, chromosome 12 at 8,006,282 bp
  • T to A, chromosome 12 at 65,227,315 bp
  • A to T, chromosome 12 at 103,612,815 bp
  • T to A, chromosome 12 at 109,591,655 bp
  • T to C, chromosome 13 at 92,494,944 bp
  • T to C, chromosome 13 at 99,431,683 bp
  • C to T, chromosome 14 at 33,042,621 bp
  • A to T, chromosome 16 at 17,307,718 bp
  • G to C, chromosome 16 at 34,879,475 bp
  • A to T, chromosome 16 at 58,455,145 bp
  • G to A, chromosome 17 at 65,382,620 bp
  • T to A, chromosome 18 at 22,521,792 bp
  • T to C, chromosome 19 at 29,954,647 bp
  • G to A, chromosome X at 163,979,301 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0548 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038740-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.