Strain Name:
C57BL/6J-MtgxR0580Btlr/Mmmh
Stock Number:
038770-MU
Citation ID:
RRID:MMRRC_038770-MU
Other Names:
R0580 (G1), C57BL/6J-MtgxR0580Btlr
Major Collection:

Gene Information

Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: Spna2, alpha-fodrin, alphaII-spectrin, 2610027H02Rik, Spna-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20740
Homologene: 2353
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 0610009J05Rik, 2610019N13Rik, Sfrs11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69207
Homologene: 36164
Srgap2
Name: SLIT-ROBO Rho GTPase activating protein 2
Synonyms: FBP2, 9930124L22Rik, Fnbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14270
Homologene: 52683
Net1
Name: neuroepithelial cell transforming gene 1
Synonyms: mNET1, 0610025H04Rik, 9530071N24Rik, Net1 homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56349
VEGA: 13
Homologene: 4283
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: AD013, 1810014J18Rik, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Akap12
Name: A kinase (PRKA) anchor protein (gravin) 12
Synonyms: SSeCKS, Tsga12, Srcs5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F37S1, D7H15F32S1, D15F32S1h, jdf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Chchd3
Name: coiled-coil-helix-coiled-coil-helix domain containing 3
Synonyms: 0610041L09Rik, 1700039J09Rik, Micos19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66075
Homologene: 9851
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 6330407G04Rik, CHMP family, member 7, 4930596K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105513
VEGA: 14
Homologene: 14613
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 58996
Homologene: 104145
Lyzl1
Name: lysozyme-like 1
Synonyms: 1700038F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67328
Homologene: 81913
Adgrg5
Name: adhesion G protein-coupled receptor G5
Synonyms: LOC382045, Gpr114, PGR27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382045
Homologene: 17828
Ext2
Name: exostosin glycosyltransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14043
HGNC: HGNC:3513
Homologene: 345
Extl3
Name: exostosin-like glycosyltransferase 3
Synonyms: 2900009G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54616
VEGA: 14
HGNC: HGNC:3518
Homologene: 1103
Carm1
Name: coactivator-associated arginine methyltransferase 1
Synonyms: Prmt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 59035
Homologene: 10990
Ino80
Name: INO80 complex subunit
Synonyms: 2310079N15Rik, INO80, 4632409L19Rik, Inoc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68142
Homologene: 75070
Slc7a5
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Synonyms: LAT1, TA1, Gm42049, D0H16S474E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20539
Homologene: 55759
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Mlxipl
Name: MLX interacting protein-like
Synonyms: bHLHd14, Wbscr14, ChREBP, WS-bHLH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 58805
Homologene: 32507
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Bpi
Name: bactericidal permeablility increasing protein
Synonyms: Bpifd1, 9230105K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329547
HGNC: HGNC:1095
Homologene: 37519
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Olfr711
Name: olfactory receptor 711
Synonyms: MOR103-4, GA_x6K02T2PBJ9-9352783-9351839
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259037
Homologene: 128111
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: mGluR8, Gprc1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Syt10
Name: synaptotagmin X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54526
Homologene: 10303
Nnmt
Name: nicotinamide N-methyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18113
HGNC: HGNC:7861
Homologene: 4496
Iqce
Name: IQ motif containing E
Synonyms: 1700028P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74239
Homologene: 49912
AC165412.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: F830032C23Rik, Nlrc2, Card15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 433070
Abcc10
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms: Mrp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Dtx2
Name: deltex 2, E3 ubiquitin ligase
Synonyms: 2610524D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74198
Homologene: 56904
AC238840.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Olfr92
Name: olfactory receptor 92
Synonyms: MOR256-29, GA_x6K02T2PSCP-1552066-1551128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258448
HGNC: HGNC:8253
Homologene: 115562
AC145553.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10, Col10a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Olfr1393
Name: olfactory receptor 1393
Synonyms: MOR256-24, GA_x6K02T2QP88-6154577-6153642, MOR256-67_i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258463
Homologene: 81347
Cpeb3
Name: cytoplasmic polyadenylation element binding protein 3
Synonyms: 4831444O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 208922
Homologene: 40992
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 88,243,950 bp
  • A to C, chromosome 1 at 105,591,694 bp
  • A to G, chromosome 1 at 131,349,501 bp
  • A to G, chromosome 2 at 30,007,575 bp
  • A to T, chromosome 2 at 93,795,725 bp
  • G to A, chromosome 2 at 119,383,481 bp
  • A to T, chromosome 2 at 158,258,295 bp
  • T to A, chromosome 3 at 59,877,049 bp
  • C to T, chromosome 3 at 158,012,067 bp
  • G to A, chromosome 5 at 123,803,669 bp
  • A to G, chromosome 5 at 135,123,975 bp
  • A to T, chromosome 5 at 136,032,326 bp
  • A to G, chromosome 5 at 140,665,401 bp
  • A to G, chromosome 6 at 27,761,371 bp
  • A to C, chromosome 6 at 32,893,390 bp
  • A to T, chromosome 7 at 33,278,570 bp
  • C to A, chromosome 7 at 38,448,275 bp
  • T to A, chromosome 7 at 56,138,791 bp
  • A to G, chromosome 7 at 106,972,240 bp
  • A to T, chromosome 8 at 15,910,528 bp
  • T to A, chromosome 8 at 88,664,406 bp
  • T to C, chromosome 8 at 90,994,563 bp
  • T to C, chromosome 8 at 94,937,344 bp
  • A to T, chromosome 8 at 121,885,116 bp
  • C to T, chromosome 9 at 21,583,584 bp
  • T to C, chromosome 9 at 48,592,300 bp
  • A to T, chromosome 10 at 4,354,741 bp
  • A to G, chromosome 10 at 34,394,952 bp
  • T to A, chromosome 11 at 49,280,622 bp
  • AGAGGAGGAGGAGGAGG to AGAGGAGGAGGAGG, chromosome 11 at 97,446,536 bp
  • A to G, chromosome 13 at 3,886,612 bp
  • A to G, chromosome 14 at 65,075,729 bp
  • C to T, chromosome 14 at 69,719,450 bp
  • A to T, chromosome 15 at 89,827,176 bp
  • T to C, chromosome 17 at 18,582,638 bp
  • G to C, chromosome 17 at 37,111,455 bp
  • C to T, chromosome 17 at 46,305,956 bp
  • A to C, chromosome 18 at 4,181,134 bp
  • T to C, chromosome 19 at 37,174,035 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0580 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038770-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.