Strain Name:
C57BL/6J-MtgxR0583Btlr/Mmmh
Stock Number:
038773-MU
Citation ID:
RRID:MMRRC_038773-MU
Other Names:
R0583 (G1), C57BL/6J-MtgxR0583Btlr
Major Collection:

Gene Information

Cdk6
Name: cyclin-dependent kinase 6
Synonyms: Crk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12571
HGNC: HGNC:1777
Homologene: 963
Crlf3
Name: cytokine receptor-like factor 3
Synonyms: cytor4, Creme9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54394
Homologene: 9327
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319493
Homologene: 32254
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231452
Homologene: 6036
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Cast
Name: calpastatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12380
VEGA: 13
HGNC: HGNC:1515
Homologene: 7658
Pacrgl
Name: PARK2 co-regulated-like
Synonyms: 4933428G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66768
VEGA: 5
Homologene: 12030
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74015
Homologene: 22869
Mef2a
Name: myocyte enhancer factor 2A
Synonyms: A430079H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17258
HGNC: HGNC:6993
Homologene: 4080
Ikzf5
Name: IKAROS family zinc finger 5
Synonyms: Zfpn1a5, 2610034F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67143
Homologene: 23363
Cd274
Name: CD274 antigen
Synonyms: Pdcd1lg1, PD-L1, B7-H1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 60533
Homologene: 8560
Cadm3
Name: cell adhesion molecule 3
Synonyms: Igsf4b, Tsll1, BIgR, Necl-1, Necl1, SynCAM3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94332
Homologene: 10919
Clec4e
Name: C-type lectin domain family 4, member e
Synonyms: Mincle, Clecsf9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56619
Homologene: 22809
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: ATP-dependent metalloprotease FtsH1, Ftsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27377
Homologene: 31996
Cyb5r1
Name: cytochrome b5 reductase 1
Synonyms: 1500005G05Rik, Nqo3a2, B5R.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72017
Homologene: 96059
2700081O15Rik
Name: RIKEN cDNA 2700081O15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 108899
Homologene: 52179
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
Sec24b
Name: Sec24 related gene family, member B (S. cerevisiae)
Synonyms: SEC24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99683
Homologene: 55968
Ubxn7
Name: UBX domain protein 7
Synonyms: Ubxd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224111
VEGA: 16
Homologene: 45585
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: Vdu1, 9830169D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170822
Homologene: 8996
Cep95
Name: centrosomal protein 95
Synonyms: Ccdc45, 4732496G21Rik, F630025I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320162
Homologene: 16297
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Tatdn2
Name: TatD DNase domain containing 2
Synonyms: mKIAA0218
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381801
Homologene: 8848
Ciita
Name: class II transactivator
Synonyms: C2ta, Gm9475
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12265
VEGA: 16
HGNC: HGNC:7067
Homologene: 207
Adgrf4
Name: adhesion G protein-coupled receptor F4
Synonyms: 4632435A09Rik, Gpr115
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78249
Homologene: 51953
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237954
Homologene: 138824
Mrgbp
Name: MRG/MORF4L binding protein
Synonyms: 1600027N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73247
Homologene: 10104
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17876
Homologene: 69079
Fhad1
Name: forkhead-associated (FHA) phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329977
Homologene: 77947
Nalcn
Name: sodium leak channel, non-selective
Synonyms: Vgcnl1, A530023G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, Heatr7b1, OTTMUSG00000020804
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224572
Homologene: 115024
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Tex10
Name: testis expressed gene 10
Synonyms: 2810462N03Rik, clone 18330, 2610206N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269536
Homologene: 32361
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 666002
Homologene: 86604
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49q1, Ly-49Q, Ly49Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170733
Olfr1085
Name: olfactory receptor 1085
Synonyms: MOR191-1, GA_x6K02T2Q125-48147264-48146323
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258583
Rnf19a
Name: ring finger protein 19A
Synonyms: XYbp, XY body protein, Dorfin, Rnf19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 30945
VEGA: 15
Homologene: 8501
Zfp692
Name: zinc finger protein 692
Synonyms: Zfp692-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103836
Homologene: 9889
Ccdc154
Name: coiled-coil domain containing 154
Synonyms: ntl, LOC207209
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 207209
Homologene: 19361
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Themis3
Name: thymocyte selection associated family member 3
Synonyms: 9130404H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74556
Homologene: 137389
Klhl11
Name: kelch-like 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217194
Homologene: 10030
Ilvbl
Name: ilvB (bacterial acetolactate synthase)-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216136
VEGA: 10
HGNC: HGNC:6041
Homologene: 68532
Pak3
Name: p21 (RAC1) activated kinase 3
Synonyms: PAK-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 18481
HGNC: HGNC:8592
Homologene: 55664
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Nfu1
Name: NFU1 iron-sulfur cluster scaffold
Synonyms: Hirip5, 0610006G17Rik, CGI-33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56748
Homologene: 6369
Prh1
Name: proline rich protein HaeIII subfamily 1
Synonyms: MP2, Prp, A-type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19131
Cblc
Name: Casitas B-lineage lymphoma c
Synonyms: 2310076I21Rik, 2310079L19Rik, Cbl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80794
Homologene: 8108
Olfr516
Name: olfactory receptor 516
Synonyms: GA_x6K02T2PBJ9-11176324-11175380, MOR268-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258720
HGNC: HGNC:8162
Homologene: 138316
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: WI-16786, WI-18508, Nope, 9330155G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
AW822073
Name: expressed sequence AW822073
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100504180
Homologene: 134545
Kcns3
Name: potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
Synonyms: D12Ertd137e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238076
VEGA: 12
HGNC: HGNC:6302
Homologene: 20518
Fastkd3
Name: FAST kinase domains 3
Synonyms: 2310010B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69577
VEGA: 13
Homologene: 11457
Nkx2-6
Name: NK2 homeobox 6
Synonyms: tinman, Nkx2.6, Tix, Nkx-2.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18092
Homologene: 22604
Ribc2
Name: RIB43A domain with coiled-coils 2
Synonyms: 4930579A10Rik, Trib
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67747
VEGA: 15
Homologene: 9230
Myg1
Name: melanocyte proliferating gene 1
Synonyms: Gamm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 60315
Homologene: 5853
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • GT to GTT, chromosome 1 at 88,256,166 bp
  • T to A, chromosome 1 at 134,407,601 bp
  • T to G, chromosome 1 at 173,341,171 bp
  • T to C, chromosome 2 at 23,186,250 bp
  • T to A, chromosome 2 at 86,658,360 bp
  • T to C, chromosome 2 at 125,097,981 bp
  • A to G, chromosome 2 at 180,584,446 bp
  • G to T, chromosome 3 at 130,041,311 bp
  • C to A, chromosome 3 at 152,368,254 bp
  • A to C, chromosome 4 at 48,451,952 bp
  • C to T, chromosome 4 at 141,903,990 bp
  • A to G, chromosome 5 at 3,473,183 bp
  • A to G, chromosome 5 at 48,380,128 bp
  • A to G, chromosome 5 at 92,305,064 bp
  • T to C, chromosome 6 at 87,009,952 bp
  • A to G, chromosome 6 at 104,776,314 bp
  • A to G, chromosome 6 at 113,702,525 bp
  • A to G, chromosome 6 at 123,283,694 bp
  • T to A, chromosome 6 at 129,868,693 bp
  • A to T, chromosome 6 at 132,571,833 bp
  • C to A, chromosome 7 at 19,792,561 bp
  • G to T, chromosome 7 at 67,235,148 bp
  • C to T, chromosome 7 at 108,845,414 bp
  • A to G, chromosome 7 at 131,391,785 bp
  • C to A, chromosome 7 at 141,807,608 bp
  • T to A, chromosome 7 at 141,856,698 bp
  • C to A, chromosome 8 at 3,439,477 bp
  • T to C, chromosome 8 at 71,715,725 bp
  • A to G, chromosome 9 at 57,257,643 bp
  • T to C, chromosome 9 at 65,121,813 bp
  • G to A, chromosome 10 at 58,223,388 bp
  • T to A, chromosome 10 at 78,583,267 bp
  • A to G, chromosome 11 at 58,310,348 bp
  • A to T, chromosome 11 at 80,059,281 bp
  • T to C, chromosome 11 at 100,464,324 bp
  • T to C, chromosome 11 at 103,498,437 bp
  • T to C, chromosome 11 at 106,814,623 bp
  • T to G, chromosome 12 at 11,091,478 bp
  • T to A, chromosome 12 at 80,199,029 bp
  • T to A, chromosome 13 at 68,585,166 bp
  • T to C, chromosome 13 at 74,713,678 bp
  • A to T, chromosome 14 at 69,174,779 bp
  • T to C, chromosome 14 at 123,294,343 bp
  • C to A, chromosome 15 at 36,253,005 bp
  • A to T, chromosome 15 at 85,132,914 bp
  • C to T, chromosome 15 at 102,337,790 bp
  • T to C, chromosome 16 at 10,523,804 bp
  • T to C, chromosome 16 at 32,375,914 bp
  • T to C, chromosome 16 at 93,755,486 bp
  • T to A, chromosome 17 at 19,676,781 bp
  • C to T, chromosome 17 at 22,618,949 bp
  • ATTT to ATT, chromosome 17 at 23,290,932 bp
  • T to A, chromosome 17 at 25,168,424 bp
  • T to C, chromosome 17 at 42,662,336 bp
  • T to C, chromosome 17 at 66,559,753 bp
  • A to G, chromosome 19 at 7,420,274 bp
  • T to A, chromosome 19 at 29,382,590 bp
  • TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC to TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC, chromosome X at 143,743,893 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0583 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038773-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.