Strain Name:
C57BL/6J-MtgxR0584Btlr/Mmmh
Stock Number:
038774-MU
Citation ID:
RRID:MMRRC_038774-MU
Other Names:
R0584 (G1), C57BL/6J-MtgxR0584Btlr
Major Collection:

Gene Information

Grp
Name: gastrin releasing peptide
Synonyms: BLP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225642
HGNC: HGNC:4605
Homologene: 1580
Prkci
Name: protein kinase C, iota
Synonyms: Pkcl, 2310021H13Rik, PKClambda, Prkcl, aPKClambda, Pkci
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18759
HGNC: HGNC:9404
Homologene: 37667
S1pr3
Name: sphingosine-1-phosphate receptor 3
Synonyms: S1P3, LPb3, Edg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13610
VEGA: 13
HGNC: HGNC:3167
Homologene: 3829
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: Gcn1l1, GCN1L, G431004K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Asxl2
Name: additional sex combs like 2, transcriptional regulator
Synonyms: 4930556B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75302
Homologene: 10102
Nop58
Name: NOP58 ribonucleoprotein
Synonyms: MSSP, Nol5, SIK similar protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 55989
Homologene: 7024
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, 4832420A03Rik, C030033M12Rik, XAP8, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skax26, ska26, Cd, skam26Jus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Umps
Name: uridine monophosphate synthetase
Synonyms: 1700095D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22247
Homologene: 319
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74015
Homologene: 22869
Casp12
Name: caspase 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12364
Homologene: 7654
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Mef2a
Name: myocyte enhancer factor 2A
Synonyms: A430079H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17258
HGNC: HGNC:6993
Homologene: 4080
Spag5
Name: sperm associated antigen 5
Synonyms: D11Bhm180e, Deepest, MAP126, Astrin, s17, Mastrin, S17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54141
Homologene: 4718
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Eh domain, SH3 domain regulator of endocytosis 2, Ese2, Sh3d1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Agtr1a
Name: angiotensin II receptor, type 1a
Synonyms: Agtr-1a, 1810074K20Rik, Angtr-1a, AT1a, Agtr1a, AT1, Agt1ar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11607
HGNC: HGNC:336
Homologene: 3556
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: FPC, tigmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, Ltbp1L, b2b1000Clo, 9430031G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Pde9a
Name: phosphodiesterase 9A
Synonyms: PDE9A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18585
HGNC: HGNC:8795
Homologene: 113565
Agfg2
Name: ArfGAP with FG repeats 2
Synonyms: Hrbl, A630095P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231801
HGNC: HGNC:5177
Homologene: 4430
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69047
Homologene: 73463
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68915
Homologene: 57502
Fam120b
Name: family with sequence similarity 120, member B
Synonyms: 4932442K08Rik, CCPG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67544
VEGA: 17
Homologene: 13033
Fam209
Name: family with sequence similarity 209
Synonyms: 1700029J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76426
Homologene: 19218
Ptprr
Name: protein tyrosine phosphatase, receptor type, R
Synonyms: PTP-SL, PTPBR7, RPTPRR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Sp6
Name: trans-acting transcription factor 6
Synonyms: Klf14, 1110025J03Rik, epiprofin, Epfn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83395
Homologene: 19879
Icosl
Name: icos ligand
Synonyms: GL50-B, GL50, B7RP-1, B7h, ICOS-L, B7-H2, LICOS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50723
VEGA: 10
Homologene: 49412
Olfr507
Name: olfactory receptor 507
Synonyms: MOR204-7, GA_x6K02T2PBJ9-10951546-10952496
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258738
Homologene: 27249
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: Ncrna00082, LOC381544, LOC381543, Gm1661
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381544
Homologene: 28727
Dppa3
Name: developmental pluripotency-associated 3
Synonyms: 2410075G02Rik, PGC7, stella
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73708
Homologene: 138189
Togaram1
Name: TOG array regulator of axonemal microtubules 1
Synonyms: A430041B07Rik, Fam179b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328108
VEGA: 12
Homologene: 15025
Abca7
Name: ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms: Abc51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Cyth4
Name: cytohesin 4
Synonyms: 2510004M07Rik, Pscd4, 5830469K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72318
VEGA: 15
HGNC: HGNC:9505
Homologene: 22750
Gm11563
Name: predicted gene 11563
Synonyms: 2310045F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040248
Homologene: 136093
Oscp1
Name: organic solute carrier partner 1
Synonyms: 6030436A01Rik, 1810007P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230751
Homologene: 71010
Ccl25
Name: chemokine (C-C motif) ligand 25
Synonyms: CKb15, TECK, Scya25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20300
Homologene: 4109
Gpd1l
Name: glycerol-3-phosphate dehydrogenase 1-like
Synonyms: 2210409H23Rik, D9Ertd660e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 333433
Homologene: 56097
Olfr775
Name: olfactory receptor 775
Synonyms: GA_x6K02T2PULF-10936819-10937757, Olfr1518, MOR111-7, MOR111-6, MOR111-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258538
Homologene: 115559
Sirt5
Name: sirtuin 5
Synonyms: 0610012J09Rik, 1500032M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68346
VEGA: 13
Homologene: 40825
Fitm1
Name: fat storage-inducing transmembrane protein 1
Synonyms: Cg10671, Fit1, 1110028A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68680
Homologene: 41695
H1f7
Name: H1.7 linker histone
Synonyms: H1T2, 1700026P10Rik, H1-7, H1fnt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70069
VEGA: 15
Fam98a
Name: family with sequence similarity 98, member A
Synonyms: 2810405J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72722
Homologene: 41042
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,239,436 bp
  • T to C, chromosome 1 at 24,224,490 bp
  • A to G, chromosome 1 at 59,706,760 bp
  • C to T, chromosome 2 at 172,474,161 bp
  • T to A, chromosome 3 at 31,025,140 bp
  • A to T, chromosome 4 at 117,229,850 bp
  • A to G, chromosome 4 at 126,083,594 bp
  • G to A, chromosome 5 at 115,595,015 bp
  • G to A, chromosome 5 at 137,667,730 bp
  • T to C, chromosome 6 at 122,629,992 bp
  • A to G, chromosome 6 at 134,456,076 bp
  • G to T, chromosome 7 at 67,235,148 bp
  • T to A, chromosome 7 at 97,662,128 bp
  • T to C, chromosome 7 at 108,622,415 bp
  • C to T, chromosome 8 at 4,354,085 bp
  • T to C, chromosome 8 at 71,715,725 bp
  • T to A, chromosome 8 at 119,738,418 bp
  • A to G, chromosome 9 at 5,352,268 bp
  • T to C, chromosome 9 at 42,347,908 bp
  • A to G, chromosome 9 at 114,914,344 bp
  • A to C, chromosome 9 at 119,670,531 bp
  • T to C, chromosome 10 at 78,071,875 bp
  • T to C, chromosome 10 at 80,011,730 bp
  • T to C, chromosome 10 at 116,251,158 bp
  • T to C, chromosome 10 at 129,250,948 bp
  • A to G, chromosome 11 at 65,990,489 bp
  • G to T, chromosome 11 at 67,360,374 bp
  • A to G, chromosome 11 at 78,304,095 bp
  • C to T, chromosome 11 at 97,022,265 bp
  • A to G, chromosome 11 at 99,658,625 bp
  • A to T, chromosome 12 at 3,496,632 bp
  • A to G, chromosome 12 at 4,697,180 bp
  • T to C, chromosome 12 at 64,967,505 bp
  • A to G, chromosome 13 at 30,381,034 bp
  • T to A, chromosome 13 at 43,394,728 bp
  • A to T, chromosome 13 at 51,419,661 bp
  • T to C, chromosome 14 at 55,576,656 bp
  • A to G, chromosome 15 at 78,609,878 bp
  • C to A, chromosome 15 at 98,257,077 bp
  • A to G, chromosome 16 at 33,959,124 bp
  • T to C, chromosome 17 at 15,402,122 bp
  • A to T, chromosome 17 at 31,459,977 bp
  • A to G, chromosome 17 at 35,666,686 bp
  • T to C, chromosome 17 at 75,363,472 bp
  • A to G, chromosome 17 at 75,544,777 bp
  • C to A, chromosome 18 at 65,873,695 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0584 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038774-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.