Strain Name:
C57BL/6J-MtgxR0589Btlr/Mmmh
Stock Number:
038779-MU
Citation ID:
RRID:MMRRC_038779-MU
Other Names:
R0589 (G1), C57BL/6J-MtgxR0589Btlr
Major Collection:

Gene Information

Dct
Name: dopachrome tautomerase
Synonyms: tyrosinase-related protein-2, TRP-2, Tyrp-2, Tyrp2, TRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13190
VEGA: 14
HGNC: HGNC:2709
Homologene: 1447
Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Synonyms: alpha-CaMKII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12322
HGNC: HGNC:1460
Homologene: 56577
Sox10
Name: SRY (sex determining region Y)-box 10
Synonyms: Sox21, gt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20665
VEGA: 15
Homologene: 5055
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Maco1
Name: macoilin 1
Synonyms: 9230118A01Rik, C61, 1110007C24Rik, Tmem57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66146
Homologene: 14449
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68070
Homologene: 23393
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: DIF-3, Zfp403, D330017P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217039
Homologene: 11750
Dhx9
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Synonyms: leukophysin, nuclear DNA helicase II, RNA helicase, Ddx9, NDH II, NDHII, RHA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Ints14
Name: integrator complex subunit 14
Synonyms: 2010321M09Rik, Vwa9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69882
VEGA: 9
Homologene: 12774
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbin, Erbb2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 59079
Homologene: 41282
Stat3
Name: signal transducer and activator of transcription 3
Synonyms: Aprf, 1110034C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20848
Homologene: 7960
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, D14Abb1e, MommeD6, Fam208a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Ddb1
Name: damage specific DNA binding protein 1
Synonyms: p127-Ddb1, damage-specific DNA-binding protein, DNA repair, DNA repair protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13194
VEGA: 19
HGNC: HGNC:2717
Homologene: 1448
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Mef2a
Name: myocyte enhancer factor 2A
Synonyms: A430079H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17258
HGNC: HGNC:6993
Homologene: 4080
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, 1110067M05Rik, Thrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327987
Homologene: 21067
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: lysyl hydroxylase 2, LH2, Plod-2, D530025C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237553
Homologene: 75007
Gpx3
Name: glutathione peroxidase 3
Synonyms: GPx, plasma GPx, extracellular GPx, EGPx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14778
HGNC: HGNC:4555
Homologene: 20480
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Grcb, Leprel2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14789
Homologene: 8401
Dnai3
Name: dynein axonemal intermediate chain 3
Synonyms: 4931433A13Rik, IC140, Ida7, Wdr63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242253
Homologene: 44922
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: MyHC-pn, Myhs-p, Myhsp, 4832426G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Ints11
Name: integrator complex subunit 11
Synonyms: 2410006F12Rik, Cpsf3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71957
Homologene: 9894
Abcc12
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Synonyms: MRP9, 4930467B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244562
Homologene: 57211
Rtcb
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: HSPC117, D10Wsu52e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 28088
Homologene: 36344
Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Synonyms: P450-3, CP12, aromatic compound inducible
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13077
VEGA: 9
HGNC: HGNC:2596
Homologene: 68082
Stard9
Name: START domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Olfr1105
Name: olfactory receptor 1105
Synonyms: GA_x6K02T2Q125-48521031-48520093, MOR172-7, MOR0-6P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258085
Homologene: 121541
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68915
Homologene: 57502
Heatr9
Name: HEAT repeat containing 9
Synonyms: Gm11435
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 629303
Homologene: 51895
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: LOC268884, 5530401I02Rik, 9530025L16Rik, 4632417D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77446
Homologene: 35276
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cbf, CBF2, Cebpa-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12607
VEGA: 17
Homologene: 4210
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234135
Homologene: 56960
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf-13b, Cf13b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Grk3
Name: G protein-coupled receptor kinase 3
Synonyms: beta ARK2, Bark-2, Adrbk-2, 4833444A01Rik, Adrbk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320129
HGNC: HGNC:290
Homologene: 21072
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Trh4, CerS5, Lass5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71949
Homologene: 23634
Olfr531
Name: olfactory receptor 531
Synonyms: GA_x6K02T2PBJ9-42551260-42550346, MOR251-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258955
Pgbd1
Name: piggyBac transposable element derived 1
Synonyms: 4921509E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319207
Homologene: 130030
Mrpl45
Name: mitochondrial ribosomal protein L45
Synonyms: 2600005P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67036
Homologene: 32647
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70866
Homologene: 86643
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434234
Homologene: 12803
Slc35c1
Name: solute carrier family 35, member C1
Synonyms: FUCT1, E430007K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228368
Homologene: 41258
Tle6
Name: transducin-like enhancer of split 6
Synonyms: Grg6, 1810057E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 114606
Homologene: 11701
Rassf5
Name: Ras association (RalGDS/AF-6) domain family member 5
Synonyms: 1300019G20Rik, Nore1B, Nore1A, Rapl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54354
Homologene: 10296
Tex44
Name: testis expressed 44
Synonyms: 1700019O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71863
Homologene: 51874
Olfr1220
Name: olfactory receptor 1220
Synonyms: GA_x6K02T2Q125-50579531-50578596, MOR233-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258902
Homologene: 74242
Fam166b
Name: family with sequence similarity 166, member B
Synonyms: 4833436C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329831
Homologene: 52229
Phtf2
Name: putative homeodomain transcription factor 2
Synonyms: 9530062N20Rik, 1110054G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68770
Homologene: 10713
Tmod2
Name: tropomodulin 2
Synonyms: NTMOD, N-Tmod, neural tropomodulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 50876
VEGA: 9
Homologene: 22817
Atf4
Name: activating transcription factor 4
Synonyms: TAXREB67, C/ATF, CREB2, Atf-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11911
VEGA: 15
HGNC: HGNC:786
Homologene: 1266
Trem1
Name: triggering receptor expressed on myeloid cells 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58217
Homologene: 10243
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,132,883 bp
  • A to G, chromosome 1 at 86,427,731 bp
  • A to T, chromosome 1 at 98,499,747 bp
  • C to T, chromosome 1 at 131,244,983 bp
  • T to C, chromosome 1 at 139,506,933 bp
  • G to T, chromosome 1 at 153,472,291 bp
  • A to T, chromosome 2 at 76,965,245 bp
  • A to T, chromosome 2 at 87,034,115 bp
  • A to G, chromosome 2 at 89,097,262 bp
  • A to G, chromosome 2 at 92,454,514 bp
  • A to G, chromosome 2 at 120,698,547 bp
  • A to G, chromosome 3 at 146,062,331 bp
  • T to C, chromosome 4 at 43,427,355 bp
  • C to A, chromosome 4 at 134,828,217 bp
  • A to T, chromosome 4 at 155,886,886 bp
  • T to A, chromosome 5 at 20,813,251 bp
  • A to G, chromosome 5 at 112,928,763 bp
  • T to A, chromosome 6 at 124,841,681 bp
  • G to T, chromosome 7 at 67,235,148 bp
  • A to G, chromosome 7 at 119,845,383 bp
  • T to G, chromosome 7 at 140,400,900 bp
  • T to C, chromosome 8 at 25,641,287 bp
  • A to T, chromosome 8 at 86,560,472 bp
  • T to A, chromosome 9 at 42,345,634 bp
  • T to A, chromosome 9 at 53,490,192 bp
  • T to C, chromosome 9 at 57,679,062 bp
  • T to C, chromosome 9 at 64,979,831 bp
  • T to C, chromosome 9 at 75,576,759 bp
  • T to A, chromosome 9 at 92,593,746 bp
  • A to G, chromosome 10 at 81,595,419 bp
  • A to C, chromosome 10 at 85,951,451 bp
  • A to T, chromosome 10 at 114,448,324 bp
  • A to G, chromosome 11 at 54,909,503 bp
  • A to G, chromosome 11 at 67,298,627 bp
  • T to C, chromosome 11 at 83,514,690 bp
  • A to T, chromosome 11 at 84,836,451 bp
  • A to G, chromosome 11 at 86,283,249 bp
  • A to T, chromosome 11 at 97,323,888 bp
  • A to T, chromosome 11 at 100,908,083 bp
  • G to T, chromosome 11 at 109,942,268 bp
  • G to A, chromosome 13 at 21,434,430 bp
  • G to T, chromosome 13 at 103,886,287 bp
  • T to C, chromosome 14 at 27,461,150 bp
  • G to T, chromosome 14 at 118,043,270 bp
  • A to G, chromosome 15 at 12,376,299 bp
  • T to G, chromosome 15 at 79,163,285 bp
  • T to A, chromosome 15 at 80,256,439 bp
  • A to T, chromosome 15 at 99,740,956 bp
  • C to A, chromosome 16 at 14,142,055 bp
  • T to G, chromosome 16 at 33,731,707 bp
  • T to C, chromosome 17 at 35,659,176 bp
  • A to G, chromosome 17 at 46,801,596 bp
  • A to G, chromosome 17 at 48,237,217 bp
  • G to A, chromosome 17 at 78,936,879 bp
  • A to G, chromosome 18 at 37,146,474 bp
  • G to A, chromosome 18 at 60,963,964 bp
  • T to G, chromosome 19 at 10,621,716 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0589 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038779-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.