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Strain Name:
C57BL/6J-MtgxR0591Btlr/Mmmh
Stock Number:
038781-MU
Citation ID:
RRID:MMRRC_038781-MU
Other Names:
R0591 (G1), C57BL/6J-MtgxR0591Btlr
Major Collection:

Strain Information

Ednrb
Name: endothelin receptor type B
Synonyms: ETb, Sox10m1, ETR-b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Agt
Name: angiotensinogen
Synonyms: Aogen, Serpina8, angiotensin precursor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11606
HGNC: HGNC:333
Homologene: 14
Plcb4
Name: phospholipase C, beta 4
Synonyms: C230058B11Rik, A930039J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Crabp1
Name: cellular retinoic acid binding protein I
Synonyms: Crabp-1, Rbp-5, CrabpI
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12903
HGNC: HGNC:2338
Homologene: 3222
Lrsam1
Name: leucine rich repeat and sterile alpha motif containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227738
Homologene: 44526
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik, Parp5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74493
Homologene: 11890
Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Synonyms: CS group B correcting gene, CSB, C130058G22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319955
VEGA: 14
HGNC: HGNC:3438
Homologene: 133552
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Apc1, 2610021O03Rik, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 2810429C13Rik, 1110031N14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235559
Homologene: 38262
Ccdc167
Name: coiled-coil domain containing 167
Synonyms: 1110021J02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68597
Homologene: 79796
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: DGKdelta, dgkd-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Nars1
Name: asparaginyl-tRNA synthetase 1
Synonyms: ASNRS, Nars
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70223
VEGA: 18
HGNC: HGNC:7643
Homologene: 68404
Golga3
Name: golgin A3
Synonyms: Mea-2, Mea2, 5430416E01Rik, G1-499-14, repro27
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: Dbs, C130040G20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17207
Homologene: 11804
Kcnj9
Name: potassium inwardly-rectifying channel, subfamily J, member 9
Synonyms: Kir3.3, Girk3, 1700085N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16524
HGNC: HGNC:6270
Homologene: 37989
Gpr12
Name: G-protein coupled receptor 12
Synonyms: Gpcr20, Gpcr12, Gpcr01
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14738
HGNC: HGNC:4466
Homologene: 3868
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Adam19
Name: ADAM metallopeptidase domain 19
Synonyms: Mltnb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11492
HGNC: HGNC:197
Homologene: 74925
Vezf1
Name: vascular endothelial zinc finger 1
Synonyms: db1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22344
Homologene: 5175
Pbrm1
Name: polybromo 1
Synonyms: BAF180, 2610016F04Rik, 2310032M22Rik, Pb1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66923
Homologene: 10044
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20259
Homologene: 36296
Katnal1
Name: katanin p60 subunit A-like 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231912
Homologene: 12942
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20536
Homologene: 129474
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr5, Jr4, ZIZ3, 9330153B10Rik, A630054M16Rik, Zizimin3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Inhba
Name: inhibin beta-A
Synonyms: activin beta-A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16323
VEGA: 13
HGNC: HGNC:6066
Homologene: 1653
Hikeshi
Name: heat shock protein nuclear import factor
Synonyms: l(7)6Rn, 1110002N09Rik, 0610007P06Rik, Hikeshi, l7Rn6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67669
Homologene: 6908
Slc44a5
Name: solute carrier family 44, member 5
Synonyms: LOC242259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242259
Homologene: 72094
Tcp11l2
Name: t-complex 11 (mouse) like 2
Synonyms: E430026E19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216198
Homologene: 17129
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Slc30a4
Name: solute carrier family 30 (zinc transporter), member 4
Synonyms: Znt4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22785
Homologene: 74984
Dglucy
Name: D-glutamate cyclase
Synonyms: 9030617O03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217830
Homologene: 11798
Tex10
Name: testis expressed gene 10
Synonyms: clone 18330, 2810462N03Rik, 2610206N19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269536
Homologene: 32361
Aadacl2fm2
Name: AADACL2 family member 2
Synonyms: Gm5538
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433597
Homologene: 79018
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Usp4
Name: ubiquitin specific peptidase 4 (proto-oncogene)
Synonyms: Unp, F730026I20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22258
Homologene: 20716
Iftap
Name: intraflagellar transport associated protein
Synonyms: NWC, B230118H07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68170
Homologene: 16348
Slc9b1
Name: solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
Synonyms: 4933424B12Rik, 1700094G20Rik, 4933425K02Rik, Nhedc1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74446
Homologene: 49914
Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Synonyms: 11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15483
HGNC: HGNC:5208
Homologene: 68471
Cactin
Name: cactin, spliceosome C complex subunit
Synonyms: 2510012J08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70312
VEGA: 10
Homologene: 69553
Vmn1r184
Name: vomeronasal 1 receptor, 184
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312477
Homologene: 74353
Ptdss1
Name: phosphatidylserine synthase 1
Synonyms: PtdSer Synthase-1, PSS-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19210
VEGA: 13
HGNC: HGNC:9587
Homologene: 7494
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Ceacam3
Name: CEA cell adhesion molecule 3
Synonyms: cea12, EG384557, Psg24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384557
HGNC: HGNC:1819
Homologene: 86971
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 252875
Homologene: 10371
Pnliprp1
Name: pancreatic lipase related protein 1
Synonyms: Plrp1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18946
VEGA: 19
HGNC: HGNC:9156
Homologene: 21253
BC051665
Name: cDNA sequence BC051665
Synonyms: cathepsin L-like
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218275
VEGA: 13
Homologene: 74298
Apol9a
Name: apolipoprotein L 9a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223672
VEGA: 15
Homologene: 77567
Or5ak23
Name: olfactory receptor family 5 subfamily AK member 23
Synonyms: GA_x6K02T2Q125-46891524-46890580, MOR203-2, Olfr993
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258427
Homologene: 79352
Ube4bos1
Name: ubiquitination factor E4B, opposite strand 1
Synonyms: A930028C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Rhcg
Name: Rhesus blood group-associated C glycoprotein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56315
Homologene: 32310
Sesn3
Name: sestrin 3
Synonyms: SEST3, 5630400E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75747
Homologene: 14386
Appl2
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Synonyms: Dip3b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216190
Homologene: 10046
Rap1b
Name: RAS related protein 1b
Synonyms: 2810443E11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215449
VEGA: 10
Homologene: 68719
Samm50
Name: SAMM50 sorting and assembly machinery component
Synonyms: 1110030L07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68653
VEGA: 15
Homologene: 41034
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,239,102 bp
  • G to T, chromosome 1 at 60,125,914 bp
  • C to T, chromosome 1 at 75,549,021 bp
  • C to T, chromosome 1 at 80,541,219 bp
  • T to A, chromosome 1 at 87,915,104 bp
  • T to C, chromosome 1 at 172,323,098 bp
  • T to C, chromosome 1 at 193,229,676 bp
  • A to G, chromosome 2 at 32,933,923 bp
  • A to G, chromosome 2 at 85,414,690 bp
  • A to T, chromosome 2 at 101,576,117 bp
  • A to T, chromosome 2 at 122,685,240 bp
  • G to T, chromosome 2 at 128,619,332 bp
  • A to G, chromosome 2 at 135,955,012 bp
  • A to G, chromosome 2 at 181,232,116 bp
  • C to A, chromosome 3 at 59,752,129 bp
  • A to G, chromosome 3 at 135,382,832 bp
  • G to T, chromosome 3 at 138,068,943 bp
  • T to A, chromosome 3 at 144,915,592 bp
  • C to T, chromosome 3 at 154,234,145 bp
  • C to T, chromosome 4 at 48,456,800 bp
  • A to C, chromosome 4 at 112,858,169 bp
  • T to G, chromosome 4 at 149,357,577 bp
  • A to C, chromosome 5 at 110,188,743 bp
  • A to G, chromosome 5 at 146,583,635 bp
  • A to T, chromosome 5 at 148,892,516 bp
  • T to C, chromosome 6 at 8,215,470 bp
  • G to A, chromosome 7 at 17,151,883 bp
  • A to T, chromosome 7 at 26,267,075 bp
  • G to A, chromosome 7 at 29,104,795 bp
  • T to A, chromosome 7 at 79,594,772 bp
  • A to T, chromosome 7 at 89,920,087 bp
  • T to G, chromosome 8 at 13,018,751 bp
  • A to T, chromosome 8 at 124,556,939 bp
  • T to C, chromosome 9 at 14,308,558 bp
  • T to A, chromosome 9 at 54,765,603 bp
  • T to A, chromosome 9 at 103,349,838 bp
  • G to A, chromosome 9 at 108,348,029 bp
  • A to G, chromosome 10 at 60,300,855 bp
  • G to T, chromosome 10 at 81,324,003 bp
  • A to T, chromosome 10 at 83,624,645 bp
  • A to T, chromosome 10 at 84,604,594 bp
  • G to A, chromosome 10 at 117,818,617 bp
  • T to C, chromosome 11 at 46,121,411 bp
  • A to T, chromosome 11 at 88,068,435 bp
  • T to A, chromosome 11 at 88,068,436 bp
  • A to G, chromosome 12 at 40,080,930 bp
  • A to T, chromosome 12 at 51,910,101 bp
  • T to C, chromosome 12 at 100,859,518 bp
  • A to T, chromosome 13 at 16,026,820 bp
  • A to G, chromosome 13 at 60,784,608 bp
  • A to G, chromosome 13 at 66,972,650 bp
  • A to G, chromosome 14 at 31,046,430 bp
  • T to C, chromosome 14 at 32,558,016 bp
  • A to T, chromosome 14 at 103,196,391 bp
  • A to T, chromosome 14 at 103,823,274 bp
  • G to A, chromosome 15 at 77,735,630 bp
  • G to A, chromosome 15 at 84,211,168 bp
  • A to G, chromosome 17 at 29,705,261 bp
  • A to T, chromosome 18 at 64,500,567 bp
  • T to A, chromosome 19 at 36,872,562 bp
  • A to G, chromosome 19 at 58,734,706 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0591 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038781-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.