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Strain Name:
C57BL/6J-MtgxR0629Btlr/Mmmh
Stock Number:
038818-MU
Citation ID:
RRID:MMRRC_038818-MU
Other Names:
R0629 (G1), C57BL/6J-MtgxR0629Btlr
Major Collection:

Strain Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik, D630049N15
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, sAC, 4930431D04Rik, Sacy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Oxsr1
Name: oxidative-stress responsive 1
Synonyms: 2810422B09Rik, 2210022N24Rik, Osr1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108737
HGNC: HGNC:8508
Homologene: 31288
Bclaf1
Name: BCL2-associated transcription factor 1
Synonyms: 2700025J07Rik, 2810454G14Rik, 2610102K23Rik, 5730534O06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72567
Homologene: 8832
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 136,172,157 bp
  • A to G, chromosome 1 at 150,101,037 bp
  • A to G, chromosome 1 at 157,564,863 bp
  • A to G, chromosome 1 at 162,958,227 bp
  • T to C, chromosome 1 at 163,060,636 bp
  • A to G, chromosome 1 at 165,543,105 bp
  • A to G, chromosome 1 at 191,831,317 bp
  • T to C, chromosome 2 at 76,828,130 bp
  • T to A, chromosome 2 at 86,676,529 bp
  • T to A, chromosome 2 at 158,439,547 bp
  • G to A, chromosome 3 at 22,210,401 bp
  • C to A, chromosome 3 at 53,479,064 bp
  • A to G, chromosome 3 at 129,788,302 bp
  • T to A, chromosome 3 at 145,072,239 bp
  • T to G, chromosome 4 at 43,669,896 bp
  • T to A, chromosome 4 at 94,638,252 bp
  • T to C, chromosome 4 at 135,925,644 bp
  • C to A, chromosome 5 at 124,885,595 bp
  • C to T, chromosome 6 at 102,203,976 bp
  • A to C, chromosome 7 at 98,085,466 bp
  • A to G, chromosome 7 at 104,487,655 bp
  • C to T, chromosome 8 at 4,677,769 bp
  • T to C, chromosome 8 at 5,098,562 bp
  • C to T, chromosome 8 at 15,027,572 bp
  • T to A, chromosome 8 at 15,069,783 bp
  • A to G, chromosome 8 at 70,594,708 bp
  • T to C, chromosome 8 at 72,753,536 bp
  • A to G, chromosome 8 at 120,088,046 bp
  • A to T, chromosome 8 at 124,674,366 bp
  • A to C, chromosome 9 at 21,140,768 bp
  • A to G, chromosome 9 at 21,914,686 bp
  • A to G, chromosome 9 at 45,721,418 bp
  • A to T, chromosome 9 at 63,425,382 bp
  • G to A, chromosome 9 at 89,984,269 bp
  • A to T, chromosome 9 at 105,727,165 bp
  • A to G, chromosome 9 at 119,241,784 bp
  • A to T, chromosome 9 at 121,367,167 bp
  • T to A, chromosome 9 at 121,660,171 bp
  • A to T, chromosome 10 at 6,832,604 bp
  • T to C, chromosome 10 at 20,333,426 bp
  • G to A, chromosome 10 at 61,211,624 bp
  • T to C, chromosome 10 at 68,516,278 bp
  • G to A, chromosome 11 at 16,869,333 bp
  • T to C, chromosome 11 at 35,853,472 bp
  • A to G, chromosome 11 at 94,409,543 bp
  • A to C, chromosome 12 at 11,092,558 bp
  • G to A, chromosome 12 at 29,811,485 bp
  • T to C, chromosome 12 at 70,883,762 bp
  • A to T, chromosome 12 at 86,988,297 bp
  • T to G, chromosome 12 at 119,202,481 bp
  • T to C, chromosome 13 at 22,827,874 bp
  • A to G, chromosome 13 at 90,000,905 bp
  • T to A, chromosome 14 at 115,552,239 bp
  • A to T, chromosome 16 at 19,565,980 bp
  • T to C, chromosome 16 at 32,793,421 bp
  • A to G, chromosome 17 at 33,135,807 bp
  • A to T, chromosome 17 at 45,507,547 bp
  • A to G, chromosome 17 at 56,708,200 bp
  • G to T, chromosome 17 at 63,471,414 bp
  • A to T, chromosome 17 at 66,338,142 bp
  • A to T, chromosome 18 at 12,419,245 bp
  • G to A, chromosome 18 at 61,078,648 bp
  • T to A, chromosome 18 at 62,933,970 bp
  • G to A, chromosome X at 7,620,434 bp
  • G to C, chromosome X at 71,938,773 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0629 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038818-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.