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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR0639Btlr/Mmmh
Stock Number:
038828-MU
Citation ID:
RRID:MMRRC_038828-MU
Other Names:
R0639 (G1), C57BL/6J-MtgxR0639Btlr
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Pou2f1
Name: POU domain, class 2, transcription factor 1
Synonyms: Oct-1C, Oct-1B, Oct-1A, oct-1, Otf-1, Otf1, 2810482H01Rik, Oct-1z, Oct1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18986
HGNC: HGNC:9212
Homologene: 37658

Additional Resources
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IMSR
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BioGPS
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KOMP Phenotyping
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Vcp
Name: valosin containing protein
Synonyms: CDC48, p97, p97/VCP, AAA ATPase p97
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269523
Homologene: 5168

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
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ClinGen
Acadl
Name: acyl-Coenzyme A dehydrogenase, long-chain
Synonyms: LCAD, C79855
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11363
HGNC: HGNC:88
Homologene: 37498

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Kat2b
Name: K(lysine) acetyltransferase 2B
Synonyms: A930006P13Rik, Pcaf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18519
HGNC: HGNC:8638
Homologene: 20834

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230935
Homologene: 14558

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,346,498 bp
  • G to A, chromosome 1 at 24,230,870 bp
  • T to A, chromosome 1 at 34,587,821 bp
  • C to T, chromosome 1 at 39,391,209 bp
  • T to C, chromosome 1 at 43,975,447 bp
  • T to A, chromosome 1 at 59,484,560 bp
  • T to C, chromosome 1 at 66,857,408 bp
  • C to T, chromosome 1 at 74,855,836 bp
  • T to C, chromosome 1 at 93,620,482 bp
  • T to C, chromosome 1 at 131,245,066 bp
  • T to A, chromosome 1 at 131,763,804 bp
  • A to C, chromosome 1 at 132,603,816 bp
  • T to C, chromosome 1 at 146,682,570 bp
  • T to C, chromosome 1 at 161,093,711 bp
  • A to T, chromosome 1 at 165,915,103 bp
  • T to A, chromosome 1 at 182,973,889 bp
  • C to A, chromosome 1 at 189,658,062 bp
  • T to C, chromosome 2 at 14,996,336 bp
  • A to G, chromosome 2 at 52,256,124 bp
  • A to G, chromosome 2 at 57,999,395 bp
  • A to T, chromosome 2 at 118,790,844 bp
  • A to G, chromosome 2 at 131,197,262 bp
  • T to C, chromosome 3 at 73,049,649 bp
  • T to C, chromosome 3 at 86,106,973 bp
  • T to C, chromosome 3 at 122,007,641 bp
  • C to T, chromosome 4 at 42,982,565 bp
  • A to G, chromosome 4 at 45,989,102 bp
  • T to C, chromosome 4 at 84,973,851 bp
  • T to C, chromosome 4 at 86,277,143 bp
  • A to G, chromosome 4 at 103,237,006 bp
  • T to C, chromosome 4 at 111,433,298 bp
  • T to C, chromosome 4 at 115,150,794 bp
  • T to C, chromosome 4 at 116,806,750 bp
  • A to G, chromosome 4 at 117,081,551 bp
  • C to A, chromosome 4 at 126,118,332 bp
  • A to T, chromosome 4 at 131,771,179 bp
  • A to C, chromosome 4 at 141,642,070 bp
  • T to A, chromosome 4 at 145,288,027 bp
  • C to G, chromosome 4 at 151,969,936 bp
  • A to G, chromosome 4 at 152,114,120 bp
  • T to C, chromosome 4 at 155,089,503 bp
  • T to C, chromosome 5 at 4,060,318 bp
  • C to T, chromosome 5 at 14,681,749 bp
  • C to T, chromosome 5 at 32,828,915 bp
  • T to C, chromosome 5 at 33,769,426 bp
  • T to C, chromosome 5 at 38,287,948 bp
  • T to C, chromosome 5 at 77,351,980 bp
  • C to T, chromosome 5 at 86,235,469 bp
  • C to T, chromosome 5 at 100,537,460 bp
  • A to G, chromosome 5 at 109,293,015 bp
  • A to T, chromosome 5 at 111,419,316 bp
  • T to A, chromosome 5 at 138,176,239 bp
  • G to T, chromosome 5 at 147,189,946 bp
  • T to A, chromosome 6 at 34,799,705 bp
  • A to C, chromosome 6 at 55,171,227 bp
  • T to C, chromosome 6 at 66,611,799 bp
  • T to A, chromosome 6 at 73,022,412 bp
  • G to T, chromosome 6 at 83,109,411 bp
  • A to T, chromosome 6 at 106,796,008 bp
  • A to T, chromosome 6 at 136,816,110 bp
  • T to A, chromosome 7 at 21,011,668 bp
  • A to G, chromosome 7 at 80,391,499 bp
  • A to T, chromosome 7 at 105,696,464 bp
  • A to G, chromosome 7 at 140,247,959 bp
  • A to G, chromosome 8 at 25,823,291 bp
  • T to C, chromosome 8 at 27,228,265 bp
  • G to T, chromosome 8 at 41,191,624 bp
  • A to T, chromosome 8 at 71,492,735 bp
  • T to G, chromosome 8 at 107,517,946 bp
  • G to A, chromosome 8 at 121,605,449 bp
  • A to G, chromosome 8 at 123,289,359 bp
  • A to G, chromosome 9 at 22,010,518 bp
  • G to A, chromosome 9 at 38,085,370 bp
  • T to A, chromosome 9 at 67,028,173 bp
  • A to T, chromosome 9 at 86,518,420 bp
  • T to A, chromosome 10 at 22,174,375 bp
  • A to C, chromosome 10 at 79,886,349 bp
  • C to A, chromosome 10 at 80,835,784 bp
  • T to G, chromosome 10 at 126,010,221 bp
  • G to A, chromosome 10 at 128,408,227 bp
  • T to A, chromosome 11 at 3,501,147 bp
  • A to G, chromosome 11 at 36,049,084 bp
  • T to A, chromosome 11 at 60,479,336 bp
  • T to C, chromosome 11 at 60,722,997 bp
  • T to A, chromosome 11 at 69,847,994 bp
  • T to C, chromosome 11 at 78,371,144 bp
  • T to C, chromosome 11 at 78,572,277 bp
  • A to G, chromosome 11 at 104,531,734 bp
  • A to T, chromosome 11 at 106,335,361 bp
  • C to A, chromosome 11 at 115,158,702 bp
  • T to G, chromosome 11 at 115,564,531 bp
  • T to C, chromosome 12 at 4,712,556 bp
  • A to T, chromosome 12 at 32,965,421 bp
  • A to G, chromosome 12 at 72,486,288 bp
  • A to C, chromosome 12 at 100,146,040 bp
  • G to A, chromosome 13 at 15,724,715 bp
  • C to A, chromosome 13 at 22,278,941 bp
  • T to C, chromosome 13 at 49,609,369 bp
  • T to A, chromosome 13 at 64,922,213 bp
  • A to T, chromosome 13 at 112,525,843 bp
  • A to G, chromosome 14 at 30,171,294 bp
  • A to T, chromosome 15 at 12,458,058 bp
  • A to G, chromosome 15 at 37,944,492 bp
  • A to G, chromosome 15 at 47,913,940 bp
  • A to T, chromosome 15 at 66,741,484 bp
  • T to C, chromosome 15 at 81,430,837 bp
  • G to A, chromosome 15 at 83,502,225 bp
  • T to A, chromosome 15 at 91,772,996 bp
  • T to A, chromosome 15 at 98,290,595 bp
  • T to C, chromosome 15 at 100,796,550 bp
  • C to A, chromosome 15 at 101,463,627 bp
  • A to T, chromosome 15 at 101,931,548 bp
  • A to G, chromosome 16 at 17,806,505 bp
  • C to T, chromosome 16 at 77,588,605 bp
  • C to A, chromosome 16 at 93,853,850 bp
  • A to G, chromosome 17 at 36,547,391 bp
  • C to T, chromosome 17 at 45,733,073 bp
  • C to A, chromosome 17 at 53,567,538 bp
  • T to A, chromosome 17 at 56,601,092 bp
  • T to A, chromosome 17 at 71,463,755 bp
  • C to T, chromosome 17 at 74,426,963 bp
  • T to C, chromosome 18 at 5,540,599 bp
  • T to A, chromosome 18 at 44,012,975 bp
  • T to A, chromosome 18 at 44,107,764 bp
  • A to T, chromosome 19 at 4,273,019 bp
  • C to A, chromosome 19 at 32,008,639 bp
  • G to A, chromosome 19 at 43,691,094 bp
  • A to G, chromosome 19 at 44,992,642 bp
  • T to C, chromosome 19 at 56,538,440 bp
Genotype Determination

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0639 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
038828-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.