Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR0671Btlr/Mmmh
Stock Number:
038856-MU
Citation ID:
RRID:MMRRC_038856-MU
Other Names:
R0671 (G1), C57BL/6J-MtgxR0671Btlr
Major Collection:
Beutler Mutagenetix

Gene Information

Gene Details

Gene Symbol: Elp2 [MGI:1889642] (Mus musculus (mouse))
Name: elongator acetyltransferase complex subunit 2
Synonyms: Statip1, StIP1, Stat3-interacting protein
Chromosome: 18
Alteration at locus: Chemically Induced
Gene Symbol: Kmt2c [MGI:2444959] (Mus musculus (mouse))
Name: lysine (K)-specific methyltransferase 2C
Synonyms: Mll3, HALR, E330008K23Rik
Chromosome: 5
Alteration at locus: Chemically Induced
Gene Symbol: Bahcc1 [MGI:2679272] (Mus musculus (mouse))
Name: BAH domain and coiled-coil containing 1
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Hcn2 [MGI:1298210] (Mus musculus (mouse))
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Synonyms: trls, HAC1
Chromosome: 10
Alteration at locus: Chemically Induced
Gene Symbol: Ep400 [MGI:1276124] (Mus musculus (mouse))
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Chromosome: 5
Alteration at locus: Chemically Induced
Gene Symbol: Mga [MGI:1352483] (Mus musculus (mouse))
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Chromosome: 2
Alteration at locus: Chemically Induced
Gene Symbol: Cadm1 [MGI:1889272] (Mus musculus (mouse))
Name: cell adhesion molecule 1
Synonyms: SgIGSF, RA175C, RA175B, RA175A, Tslc1, 2900073G06Rik, Necl2, RA175N, SynCam, Igsf4a, Igsf4, 3100001I08Rik
Chromosome: 9
Alteration at locus: Chemically Induced
See All Alterations
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,155,128 bp
  • T to C, chromosome 1 at 78,664,735 bp
  • C to A, chromosome 1 at 88,242,420 bp
  • G to T, chromosome 1 at 89,993,171 bp
  • T to G, chromosome 1 at 185,356,611 bp
  • C to T, chromosome 2 at 36,153,698 bp
  • A to C, chromosome 2 at 111,204,137 bp
  • A to T, chromosome 2 at 119,919,910 bp
  • A to G, chromosome 2 at 160,908,329 bp
  • A to G, chromosome 3 at 59,264,929 bp
  • G to A, chromosome 3 at 62,493,741 bp
  • T to C, chromosome 3 at 79,663,293 bp
  • T to C, chromosome 3 at 94,472,239 bp
  • G to A, chromosome 3 at 142,565,390 bp
  • T to A, chromosome 4 at 34,630,505 bp
  • A to G, chromosome 4 at 43,002,998 bp
  • G to T, chromosome 4 at 43,291,672 bp
  • A to G, chromosome 4 at 90,223,919 bp
  • A to G, chromosome 4 at 96,071,695 bp
  • G to T, chromosome 4 at 112,255,777 bp
  • A to G, chromosome 4 at 137,553,280 bp
  • G to A, chromosome 4 at 141,195,239 bp
  • T to C, chromosome 4 at 151,028,831 bp
  • T to C, chromosome 4 at 152,307,468 bp
  • A to T, chromosome 5 at 25,404,365 bp
  • A to G, chromosome 5 at 34,748,267 bp
  • T to C, chromosome 5 at 64,954,592 bp
  • T to C, chromosome 5 at 65,807,437 bp
  • T to A, chromosome 5 at 81,560,905 bp
  • G to A, chromosome 5 at 110,688,196 bp
  • T to C, chromosome 5 at 112,692,766 bp
  • C to T, chromosome 5 at 125,049,387 bp
  • G to T, chromosome 6 at 48,490,391 bp
  • A to G, chromosome 6 at 65,597,363 bp
  • A to T, chromosome 6 at 71,871,557 bp
  • A to G, chromosome 6 at 87,375,818 bp
  • T to A, chromosome 6 at 115,249,853 bp
  • G to A, chromosome 6 at 115,803,805 bp
  • A to G, chromosome 6 at 122,954,034 bp
  • T to C, chromosome 6 at 129,740,208 bp
  • T to G, chromosome 6 at 133,036,350 bp
  • A to T, chromosome 7 at 21,260,511 bp
  • T to C, chromosome 7 at 31,109,160 bp
  • A to T, chromosome 7 at 35,197,333 bp
  • A to T, chromosome 7 at 38,221,402 bp
  • T to C, chromosome 7 at 55,923,962 bp
  • A to T, chromosome 7 at 80,320,217 bp
  • A to T, chromosome 7 at 82,523,182 bp
  • C to A, chromosome 7 at 108,104,156 bp
  • A to G, chromosome 7 at 140,667,677 bp
  • T to C, chromosome 7 at 143,781,517 bp
  • T to C, chromosome 8 at 84,003,008 bp
  • T to A, chromosome 8 at 85,875,693 bp
  • T to A, chromosome 8 at 94,548,342 bp
  • G to A, chromosome 9 at 21,804,627 bp
  • T to A, chromosome 9 at 27,087,477 bp
  • T to A, chromosome 9 at 38,085,127 bp
  • T to A, chromosome 9 at 47,813,806 bp
  • A to G, chromosome 9 at 70,765,941 bp
  • G to T, chromosome 9 at 73,075,433 bp
  • G to T, chromosome 9 at 77,786,798 bp
  • A to T, chromosome 9 at 79,819,390 bp
  • A to T, chromosome 9 at 90,222,505 bp
  • T to C, chromosome 9 at 121,448,955 bp
  • G to C, chromosome 10 at 79,734,232 bp
  • A to T, chromosome 10 at 79,761,607 bp
  • A to G, chromosome 10 at 88,443,304 bp
  • T to A, chromosome 10 at 94,799,332 bp
  • G to A, chromosome 11 at 23,665,831 bp
  • A to T, chromosome 11 at 29,805,065 bp
  • T to A, chromosome 11 at 58,841,855 bp
  • G to A, chromosome 11 at 86,152,667 bp
  • A to T, chromosome 11 at 87,762,809 bp
  • A to G, chromosome 11 at 96,107,528 bp
  • T to C, chromosome 11 at 98,230,109 bp
  • A to G, chromosome 11 at 116,108,352 bp
  • T to A, chromosome 11 at 117,873,157 bp
  • A to G, chromosome 11 at 120,287,320 bp
  • A to T, chromosome 12 at 4,249,758 bp
  • A to G, chromosome 12 at 36,317,341 bp
  • A to T, chromosome 12 at 51,412,628 bp
  • G to A, chromosome 12 at 77,475,017 bp
  • C to T, chromosome 12 at 91,740,466 bp
  • A to T, chromosome 13 at 56,638,726 bp
  • T to C, chromosome 14 at 45,469,319 bp
  • T to C, chromosome 14 at 50,892,394 bp
  • A to G, chromosome 14 at 51,105,050 bp
  • T to A, chromosome 14 at 63,011,838 bp
  • A to T, chromosome 14 at 103,194,588 bp
  • A to G, chromosome 15 at 75,928,958 bp
  • T to C, chromosome 15 at 81,616,134 bp
  • A to G, chromosome 15 at 89,157,981 bp
  • A to G, chromosome 15 at 100,621,852 bp
  • T to C, chromosome 16 at 10,241,879 bp
  • T to A, chromosome 16 at 20,550,487 bp
  • T to C, chromosome 16 at 29,602,207 bp
  • T to C, chromosome 16 at 34,116,408 bp
  • T to C, chromosome 16 at 84,734,394 bp
  • A to T, chromosome 16 at 90,720,673 bp
  • T to C, chromosome 17 at 14,928,396 bp
  • A to G, chromosome 17 at 24,281,249 bp
  • G to A, chromosome 17 at 25,113,165 bp
  • G to T, chromosome 17 at 25,167,285 bp
  • T to G, chromosome 17 at 25,728,524 bp
  • T to C, chromosome 17 at 25,846,393 bp
  • T to G, chromosome 17 at 46,590,312 bp
  • G to A, chromosome 17 at 48,166,656 bp
  • T to A, chromosome 17 at 52,978,113 bp
  • A to G, chromosome 17 at 74,339,451 bp
  • C to T, chromosome 18 at 10,474,303 bp
  • T to C, chromosome 18 at 12,477,590 bp
  • T to C, chromosome 18 at 24,612,442 bp
  • T to C, chromosome 18 at 37,307,742 bp
  • A to G, chromosome 19 at 4,626,188 bp
  • A to G, chromosome 19 at 37,686,561 bp
  • G to T, chromosome 19 at 40,937,667 bp
Genotype Determination
ES Cell Line
N/A

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
MeSH Terms
    Strain Development
    C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
    Suggested Control Mice
    Wild-type littermates or C57BL/6J mice

    Strain Origin

    Donor
    Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
    Primary Reference
    MUTAGENETIX record for R0671 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

    Colony and Husbandry Information

    Health Status Report

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .

    Appearance

    Coat Color
    Black

    Breeding

    MMRRC Breeding System
    Random intra-strain mating
    Breeding Scheme(s)
    When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
    Overall Breeding Performance
    Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

    Reproductive Statistics

    Average litter size
    Undetermined
    Recommended wean age
    3 weeks

    Order Request Information

    Availability Level

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Conditions of Distribution

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Fees

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    038856-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.


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