Strain Name:
C57BL/6J-MtgxR0674Btlr/Mmmh
Stock Number:
038859-MU
Citation ID:
RRID:MMRRC_038859-MU
Other Names:
R0674 (G1), C57BL/6J-MtgxR0674Btlr
Major Collection:

Gene Information

Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Synonyms: (a)3, alpha 3, neuronal nicotinic acetylcholine receptor, alpha 3 subunit, Acra-3, Acra3, A730007P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110834
VEGA: 9
HGNC: HGNC:1957
Homologene: 591
Ptx3
Name: pentraxin related gene
Synonyms: TSG-14, pentraxin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19288
HGNC: HGNC:9692
Homologene: 7500
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C030017F07Rik, C130076O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Cd2ap
Name: CD2-associated protein
Synonyms: METS-1, Mets1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12488
VEGA: 17
Homologene: 7663
Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 1190003A07Rik, U5-102K, ANT-1, 2610031L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68879
Homologene: 5368
Tiparp
Name: TCDD-inducible poly(ADP-ribose) polymerase
Synonyms: DDF1, PARP-7, PARP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99929
Homologene: 9167
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: aldosterone synthase, Cyp11b-2, Cyp11b, steroid-11-beta-hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13072
Homologene: 128035
Nek6
Name: NIMA (never in mitosis gene a)-related expressed kinase 6
Synonyms: 1300007C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59126
HGNC: HGNC:7749
Homologene: 49379
Luzp1
Name: leucine zipper protein 1
Synonyms: Luzp, 2700072H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269593
Homologene: 11545
Fus
Name: fused in sarcoma
Synonyms: translocated in liposarcoma, Tls, hnRNP P2, pigpen, D930039C12Rik, D430004D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233908
HGNC: HGNC:4010
Homologene: 134091
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99633
Homologene: 22712
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, 2900054P12Rik, Gcap14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72972
Homologene: 10367
Ptprm
Name: protein tyrosine phosphatase, receptor type, M
Synonyms: RPTPmu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Oas1d
Name: 2'-5' oligoadenylate synthetase 1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100535
HGNC: HGNC:8086
Homologene: 110815
Pisd
Name: phosphatidylserine decarboxylase
Synonyms: 9030221M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320951
HGNC: HGNC:8999
Homologene: 81653
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Tcp1
Name: t-complex protein 1
Synonyms: Ccta, c-cpn, TRic, CCT, Tcp-1, Tp63, p63, Cct1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21454
Homologene: 5656
Ralbp1
Name: ralA binding protein 1
Synonyms: Rip1, RLIP76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19765
VEGA: 17
HGNC: HGNC:9841
Homologene: 4940
Maml1
Name: mastermind like transcriptional coactivator 1
Synonyms: Mam-1, D930008C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103806
Homologene: 8845
Cd2bp2
Name: CD2 cytoplasmic tail binding protein 2
Synonyms: 2410024K20Rik, 1500011B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70233
HGNC: HGNC:1656
Homologene: 4455
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Atp2a3
Name: ATPase, Ca++ transporting, ubiquitous
Synonyms: Serca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53313
HGNC: HGNC:813
Homologene: 69131
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: ADAR1, mZaADAR, Adar1p150, Adar1p110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Ddr1
Name: discoidin domain receptor family, member 1
Synonyms: CD167a, Cak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12305
HGNC: HGNC:2730
Homologene: 68212
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: D330020E01Rik, pcy, nephrocystin 3, 3632410F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Itgam
Name: integrin alpha M
Synonyms: complement component receptor 3 alpha, CD11B (p170), Mac-1 alpha, Mac-1, complement receptor type 3, CR3, CD11b/CD18, Mac-1a, F730045J24Rik, Ly-40, Cd11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224572
Homologene: 115024
Zpr1
Name: ZPR1 zinc finger
Synonyms: ZPR1, Zfp259
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22687
Homologene: 2900
Krt81
Name: keratin 81
Synonyms: Krt2-19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64818
VEGA: 15
HGNC: HGNC:6458
Homologene: 55645
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74441
Homologene: 65259
Vsig10
Name: V-set and immunoglobulin domain containing 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231668
Homologene: 10414
Nr1d2
Name: nuclear receptor subfamily 1, group D, member 2
Synonyms: Rev-erb beta, RVR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 353187
HGNC: HGNC:7963
Homologene: 3763
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Pex5l
Name: peroxisomal biogenesis factor 5-like
Synonyms: 1700016J08Rik, PXR2, TRIP8b, Pex2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 58869
Homologene: 9562
Tssk2
Name: testis-specific serine kinase 2
Synonyms: Tsk2, SPOGA2, DGS-G, Stk22b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22115
VEGA: 16
Homologene: 31512
Bace2
Name: beta-site APP-cleaving enzyme 2
Synonyms: 1110059C24Rik, CEAP1, CDA13, ASP21, ALP56, BAE2, ARP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 56175
VEGA: 16
HGNC: HGNC:934
Homologene: 22696
Zfp52
Name: zinc finger protein 52
Synonyms: zfec29, Zfp-52, KRAB11, Zfp76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22710
VEGA: 17
Homologene: 77326
Wnt11
Name: wingless-type MMTV integration site family, member 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22411
Homologene: 20970
Qrsl1
Name: glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Synonyms: GatA, 2700038P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76563
Homologene: 6699
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC385766, LOC239731, RIM-BP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239731
Homologene: 77940
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Olfr1306
Name: olfactory receptor 1306
Synonyms: GA_x6K02T2Q125-72954873-72953935, MOR245-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258023
Homologene: 128383
Olfr92
Name: olfactory receptor 92
Synonyms: MOR256-29, GA_x6K02T2PSCP-1552066-1551128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258448
HGNC: HGNC:8253
Homologene: 115562
Krt222
Name: keratin 222
Synonyms: 6330509G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268481
Homologene: 17556
Zar1
Name: zygote arrest 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 317755
Homologene: 18370
Prdm12
Name: PR domain containing 12
Synonyms: LOC381359
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381359
Homologene: 10999
Olfr65
Name: olfactory receptor 65
Synonyms: 5'[b]3, MOR1-2, GA_x6K02T2PBJ9-6634906-6633983
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18365
Homologene: 66459
Myzap
Name: myocardial zonula adherens protein
Synonyms: Grinl1a7, Myozap, Gcom1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102371
Homologene: 134156
Erlec1
Name: endoplasmic reticulum lectin 1
Synonyms: 4933407N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66753
Homologene: 9247
Gml
Name: glycosylphosphatidylinositol anchored molecule like
Synonyms: EG625599
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 625599
HGNC: HGNC:4375
Homologene: 48071
Csrnp2
Name: cysteine-serine-rich nuclear protein 2
Synonyms: CSRNP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207785
VEGA: 15
Homologene: 32743
Iglc2
Name: immunoglobulin lambda constant 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110786
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 40,003,815 bp
  • A to G, chromosome 1 at 66,413,202 bp
  • T to A, chromosome 1 at 97,104,773 bp
  • A to G, chromosome 1 at 194,649,475 bp
  • A to G, chromosome 2 at 31,643,912 bp
  • G to C, chromosome 2 at 38,558,904 bp
  • T to C, chromosome 2 at 76,945,479 bp
  • A to T, chromosome 2 at 111,912,673 bp
  • G to A, chromosome 2 at 150,815,134 bp
  • T to C, chromosome 2 at 154,564,109 bp
  • A to G, chromosome 2 at 181,631,974 bp
  • A to T, chromosome 3 at 32,952,616 bp
  • T to A, chromosome 3 at 37,044,626 bp
  • T to C, chromosome 3 at 65,553,165 bp
  • T to A, chromosome 3 at 66,224,727 bp
  • A to G, chromosome 3 at 89,749,823 bp
  • A to T, chromosome 3 at 148,837,679 bp
  • C to T, chromosome 4 at 136,543,457 bp
  • C to T, chromosome 5 at 32,774,437 bp
  • T to A, chromosome 5 at 72,580,300 bp
  • C to T, chromosome 5 at 117,343,846 bp
  • T to C, chromosome 5 at 120,919,986 bp
  • T to C, chromosome 7 at 98,846,528 bp
  • T to C, chromosome 7 at 103,907,255 bp
  • C to T, chromosome 7 at 127,194,836 bp
  • T to A, chromosome 7 at 127,972,776 bp
  • T to C, chromosome 7 at 128,116,218 bp
  • T to C, chromosome 8 at 16,000,550 bp
  • T to A, chromosome 9 at 46,275,449 bp
  • C to A, chromosome 9 at 55,015,172 bp
  • T to C, chromosome 9 at 66,501,192 bp
  • T to C, chromosome 9 at 71,515,144 bp
  • T to C, chromosome 9 at 104,036,282 bp
  • C to A, chromosome 9 at 119,178,542 bp
  • A to G, chromosome 10 at 43,896,001 bp
  • A to T, chromosome 11 at 30,935,073 bp
  • G to T, chromosome 11 at 50,258,058 bp
  • T to C, chromosome 11 at 72,981,885 bp
  • T to A, chromosome 11 at 99,236,260 bp
  • T to C, chromosome 12 at 11,458,817 bp
  • A to T, chromosome 12 at 44,564,322 bp
  • C to A, chromosome 13 at 93,092,791 bp
  • T to C, chromosome 13 at 100,223,199 bp
  • T to C, chromosome 14 at 18,215,086 bp
  • A to G, chromosome 14 at 36,918,591 bp
  • G to A, chromosome 15 at 74,813,860 bp
  • G to A, chromosome 15 at 74,855,544 bp
  • A to T, chromosome 15 at 100,487,991 bp
  • C to A, chromosome 15 at 101,463,627 bp
  • T to C, chromosome 16 at 17,212,737 bp
  • A to G, chromosome 16 at 17,899,066 bp
  • A to G, chromosome 16 at 19,198,841 bp
  • T to C, chromosome 16 at 29,248,350 bp
  • G to A, chromosome 16 at 97,436,749 bp
  • T to C, chromosome 17 at 12,923,244 bp
  • T to A, chromosome 17 at 19,677,867 bp
  • A to T, chromosome 17 at 21,561,846 bp
  • G to T, chromosome 17 at 35,689,669 bp
  • G to C, chromosome 17 at 37,111,455 bp
  • T to A, chromosome 17 at 42,845,392 bp
  • C to T, chromosome 17 at 65,852,753 bp
  • G to A, chromosome 17 at 67,191,341 bp
  • A to G, chromosome 19 at 24,131,316 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0674 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038859-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.