Strain Name:
C57BL/6J-MtgxR0691Btlr/Mmmh
Stock Number:
038876-MU
Citation ID:
RRID:MMRRC_038876-MU
Other Names:
R0691 (G1), C57BL/6J-MtgxR0691Btlr
Major Collection:

Gene Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, B130038B15Rik, OREBP, TonEBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: Dhm2, mXrn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24127
Homologene: 5894
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Gck
Name: glucokinase
Synonyms: Gls006, Hlb62, hexokinase 4, MODY2, HK4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103988
HGNC: HGNC:4195
Homologene: 55440
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Srrm1
Name: serine/arginine repetitive matrix 1
Synonyms: SRm160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 51796
Snrnp70
Name: small nuclear ribonucleoprotein 70 (U1)
Synonyms: Srnp70, 3200002N22Rik, U1-70, Snrp70, 2700022N21Rik, Rnulp70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20637
Homologene: 20672
Mier1
Name: MEIR1 treanscription regulator
Synonyms: 4933425I22Rik, 5830411K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71148
Homologene: 136176
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: Duplin, 5830451P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67772
Homologene: 72405
Tk2
Name: thymidine kinase 2, mitochondrial
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57813
Homologene: 3392
Acy1
Name: aminoacylase 1
Synonyms: 1110014J22Rik, Acy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109652
HGNC: HGNC:177
Homologene: 110440
Piwil1
Name: piwi-like RNA-mediated gene silencing 1
Synonyms: MIWI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57749
HGNC: HGNC:9007
Homologene: 37963
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Krt33a
Name: keratin 33A
Synonyms: 2310015J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71888
Homologene: 74433
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: Zubr1, LOC381562, p600, 1810009A16Rik, D930005K06Rik, A930005E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Sec22b
Name: SEC22 homolog B, vesicle trafficking protein
Synonyms: ERS-24, Sec22l1, 4930564D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20333
Homologene: 3597
Cenpe
Name: centromere protein E
Synonyms: 312kDa, Kif10, N-7 kinesin, CENP-E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Dera
Name: deoxyribose-phosphate aldolase (putative)
Synonyms: 2500002K03Rik, 2010002D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232449
Homologene: 14562
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99326
Homologene: 13003
Txndc5
Name: thioredoxin domain containing 5
Synonyms: ERp46, PC-TRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105245
Homologene: 11125
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Spint1
Name: serine protease inhibitor, Kunitz type 1
Synonyms: HAI-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20732
Homologene: 9653
Lct
Name: lactase
Synonyms: Lphl, LOC226413, LPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Anpep
Name: alanyl (membrane) aminopeptidase
Synonyms: Cd13, Apn, aminopeptidase N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: A930014J19Rik, DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Cntn3
Name: contactin 3
Synonyms: Pang
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18488
HGNC: HGNC:2173
Homologene: 7461
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, Adgrc2, mfmi1, flamingo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Gucy1b1
Name: guanylate cyclase 1, soluble, beta 1
Synonyms: Gucy1b3, beta 1 sGC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54195
HGNC: HGNC:4687
Homologene: 664
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Gprc2a-rs2, Casr-rs2, EG637873
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637873
Homologene: 129683
Fam160b2
Name: family with sequence similarity 160, member B2
Synonyms: Rai16, G430067P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239170
VEGA: 14
Homologene: 23379
Gm9581
Name: predicted gene 9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Abcc9
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms: SUR2B, Sur2, SUR2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Rgma
Name: repulsive guidance molecule family member A
Synonyms: RGM domain family, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244058
Homologene: 10626
Fam75d3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Olfr382
Name: olfactory receptor 382
Synonyms: GA_x6K02T2P1NL-3676608-3675670, MOR135-14, MOR135-31_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258435
Homologene: 17252
Dhrs7
Name: dehydrogenase/reductase (SDR family) member 7
Synonyms: retDSR4, retSDR4, 5730564L20Rik, 2310016E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66375
VEGA: 12
Homologene: 9350
Dtwd2
Name: DTW domain containing 2
Synonyms: 1190002H09Rik, 8030470C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 68857
Homologene: 79701
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10a-1, Col10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Ccdc32
Name: coiled-coil domain containing 32
Synonyms: LOC269336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269336
Homologene: 14157
Fermt1
Name: fermitin family member 1
Synonyms: 5830467P10Rik, Kindlin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241639
Homologene: 9773
Lce1e
Name: late cornified envelope 1E
Synonyms: 1110031B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68694
Ifna2
Name: interferon alpha 2
Synonyms: Ifa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15965
HGNC: HGNC:5425
Homologene: 68536
Zar1l
Name: zygote arrest 1-like
Synonyms: LOC545824
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 545824
Homologene: 85370
Olfr807
Name: olfactory receptor 807
Synonyms: GA_x6K02T2PULF-11434134-11433199, MOR117-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258931
Homologene: 27300
Cts7
Name: cathepsin 7
Synonyms: CTS1, Epcs71, Epcs24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56092
VEGA: 13
Homologene: 75110
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 128,308,234 bp
  • A to G, chromosome 1 at 180,144,835 bp
  • A to G, chromosome 2 at 33,085,907 bp
  • A to T, chromosome 2 at 69,451,380 bp
  • A to G, chromosome 2 at 119,027,129 bp
  • A to G, chromosome 2 at 119,246,467 bp
  • A to G, chromosome 2 at 132,906,733 bp
  • A to T, chromosome 3 at 82,045,634 bp
  • G to A, chromosome 3 at 92,707,756 bp
  • A to G, chromosome 3 at 97,912,674 bp
  • A to G, chromosome 3 at 108,412,623 bp
  • A to G, chromosome 3 at 135,217,305 bp
  • A to C, chromosome 4 at 88,683,658 bp
  • A to G, chromosome 4 at 103,139,502 bp
  • G to A, chromosome 4 at 135,324,991 bp
  • G to A, chromosome 4 at 139,423,906 bp
  • G to T, chromosome 5 at 128,743,307 bp
  • A to T, chromosome 5 at 150,512,942 bp
  • T to C, chromosome 6 at 102,168,947 bp
  • T to C, chromosome 6 at 137,796,747 bp
  • T to C, chromosome 6 at 142,639,253 bp
  • T to C, chromosome 7 at 42,300,420 bp
  • T to C, chromosome 7 at 45,387,245 bp
  • T to C, chromosome 7 at 73,409,412 bp
  • T to G, chromosome 7 at 79,839,299 bp
  • A to G, chromosome 8 at 104,231,192 bp
  • A to G, chromosome 8 at 107,355,605 bp
  • A to T, chromosome 9 at 42,384,341 bp
  • T to A, chromosome 9 at 95,973,539 bp
  • A to T, chromosome 9 at 106,435,871 bp
  • A to G, chromosome 10 at 34,395,696 bp
  • A to G, chromosome 10 at 128,723,260 bp
  • G to A, chromosome 10 at 129,755,402 bp
  • T to C, chromosome 11 at 5,906,691 bp
  • C to A, chromosome 11 at 73,516,844 bp
  • T to G, chromosome 11 at 100,012,715 bp
  • T to C, chromosome 11 at 113,794,920 bp
  • T to A, chromosome 12 at 72,652,351 bp
  • T to C, chromosome 13 at 38,507,896 bp
  • A to G, chromosome 13 at 59,700,385 bp
  • A to G, chromosome 13 at 61,355,734 bp
  • T to C, chromosome 14 at 7,890,810 bp
  • T to A, chromosome 14 at 50,866,844 bp
  • T to C, chromosome 14 at 52,213,433 bp
  • A to T, chromosome 14 at 55,772,647 bp
  • T to C, chromosome 14 at 70,588,287 bp
  • A to C, chromosome 16 at 59,565,211 bp
  • C to T, chromosome 17 at 67,896,164 bp
  • G to T, chromosome 18 at 44,445,860 bp
  • A to G, chromosome 18 at 49,728,357 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0691 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038876-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.