Strain Name:
C57BL/6J-MtgxR0696Btlr/Mmmh
Stock Number:
038880-MU
Citation ID:
RRID:MMRRC_038880-MU
Other Names:
R0696 (G1), C57BL/6J-MtgxR0696Btlr
Major Collection:

Strain Information

Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74100
Homologene: 32306
Mybl1
Name: myeloblastosis oncogene-like 1
Synonyms: A-myb, repro9, G1-419-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17864
HGNC: HGNC:7547
Homologene: 32045
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 319765
Homologene: 4774
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Autotaxin, Npps2, PD-Ialpha, Pdnp2, ATX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Zfp101
Name: zinc finger protein 101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22643
Homologene: 137226
Lmnb1
Name: lamin B1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16906
HGNC: HGNC:6637
Homologene: 55912
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2d, Bat2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226562
Homologene: 41015
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Atp6v1a
Name: ATPase, H+ transporting, lysosomal V1 subunit A
Synonyms: VPP2, VA68, Atp6a1, lysosomal 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11964
HGNC: HGNC:851
Homologene: 123934
Cul7
Name: cullin 7
Synonyms: p193, 2510004L20Rik, p185, C230011P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66515
Homologene: 56683
St8sia5
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms: ST8SiaV, Siat8e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225742
Homologene: 8331
Crispld1
Name: cysteine-rich secretory protein LCCL domain containing 1
Synonyms: Cocoacrisp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 83691
Homologene: 12857
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Tmem81
Name: transmembrane protein 81
Synonyms: 4930429O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74626
Homologene: 12579
Cdh6
Name: cadherin 6
Synonyms: K-cadherin, cad6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105827
VEGA: 15
Homologene: 18649
Cd209a
Name: CD209a antigen
Synonyms: CIRE, CD209, Dcsign, DC-SIGN1, DC-SIGN, SIGNR5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170786
HGNC: HGNC:1641
Homologene: 129771
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: ZNFPR1B1, Prdm3, MDS1-EVI1, Evi-1, D630039M04Rik, Jbo, Evi1, Mds1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Cyp7b1
Name: cytochrome P450, family 7, subfamily b, polypeptide 1
Synonyms: hct-1, D3Ertd552e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13123
HGNC: HGNC:2652
Homologene: 3544
Slc7a1
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Synonyms: Rev-1, Rec-1, Atrc1, Atrc-1, 4831426K01Rik, mCAT-1, Cat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11987
Homologene: 20658
Cdsn
Name: corneodesmosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 386463
HGNC: HGNC:1802
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Zfp820
Name: zinc finger protein 820
Synonyms: 2610036F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75424
VEGA: 17
Rgma
Name: repulsive guidance molecule family member A
Synonyms: RGM domain family, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244058
Homologene: 10626
Uap1
Name: UDP-N-acetylglucosamine pyrophosphorylase 1
Synonyms: ESTM38, SPAG2, AGX1, AgX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107652
Homologene: 2342
Gm4953
Name: predicted pseudogene 4953
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240853
Stx19
Name: syntaxin 19
Synonyms: A030009B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68159
Homologene: 55777
H2-DMb2
Name: histocompatibility 2, class II, locus Mb2
Synonyms: H2-Mb2, H-2Mb2, H2-M beta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15000
HGNC: HGNC:4935
Homologene: 68231
Bcorl1
Name: BCL6 co-repressor-like 1
Synonyms: 6720425J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 320376
Homologene: 41458
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 9,673,148 bp
  • T to A, chromosome 1 at 17,747,492 bp
  • T to A, chromosome 1 at 82,492,549 bp
  • C to G, chromosome 1 at 132,507,829 bp
  • A to G, chromosome 1 at 135,532,614 bp
  • ATCCTCCTCCTCCTCCT to ATCCTCCTCCTCCT, chromosome 1 at 159,168,352 bp
  • C to T, chromosome 1 at 162,708,852 bp
  • G to A, chromosome 1 at 170,149,274 bp
  • T to C, chromosome 3 at 18,072,585 bp
  • T to C, chromosome 3 at 29,956,389 bp
  • A to G, chromosome 4 at 32,698,761 bp
  • A to T, chromosome 5 at 148,340,556 bp
  • T to C, chromosome 7 at 73,409,412 bp
  • C to A, chromosome 8 at 3,748,384 bp
  • C to A, chromosome 8 at 15,065,854 bp
  • A to T, chromosome 9 at 112,183,589 bp
  • A to G, chromosome 15 at 13,051,332 bp
  • T to C, chromosome 15 at 47,847,173 bp
  • C to T, chromosome 15 at 54,897,696 bp
  • T to C, chromosome 15 at 97,245,974 bp
  • A to T, chromosome 16 at 22,080,125 bp
  • G to T, chromosome 16 at 44,087,471 bp
  • A to G, chromosome 16 at 62,822,043 bp
  • A to G, chromosome 17 at 21,820,060 bp
  • C to T, chromosome 17 at 33,381,427 bp
  • T to C, chromosome 17 at 34,150,782 bp
  • A to T, chromosome 17 at 35,555,996 bp
  • C to T, chromosome 17 at 46,659,608 bp
  • A to G, chromosome 18 at 56,740,721 bp
  • A to G, chromosome 18 at 77,254,464 bp
  • C to A, chromosome X at 48,406,018 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0696 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038880-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.