Strain Name:
C57BL/6J-MtgxR0715Btlr/Mmmh
Stock Number:
038898-MU
Citation ID:
RRID:MMRRC_038898-MU
Other Names:
R0715 (G1), C57BL/6J-MtgxR0715Btlr
Major Collection:

Strain Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Fzd8
Name: frizzled class receptor 8
Synonyms: mFZ8, Fz8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14370
VEGA: 18
HGNC: HGNC:4046
Homologene: 40606
Asah2
Name: N-acylsphingosine amidohydrolase 2
Synonyms: neutral/alkaline ceramidase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54447
VEGA: 19
Homologene: 10310
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Zfp516
Name: zinc finger protein 516
Synonyms: C330029B10Rik, Zfp26l
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Spt5, Supt5h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20924
Homologene: 2384
Slc12a3
Name: solute carrier family 12, member 3
Synonyms: TSC, NCC
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20497
Homologene: 287
Osbpl11
Name: oxysterol binding protein-like 11
Synonyms: ORP-11
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106326
Homologene: 23385
Ckap2l
Name: cytoskeleton associated protein 2-like
Synonyms: 2610318C08Rik, Radmis, 2010016H04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70466
Homologene: 51866
Zswim7
Name: zinc finger SWIM-type containing 7
Synonyms: 2410012H22Rik, SWS1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69747
Homologene: 15565
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2810409N01Rik, 2610101O16Rik, Gtl4, cat eye syndrome chromosome region, candidate 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: 6030465E24Rik, C530005A01Rik, spastic paraplegia 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Gm9631
Name: predicted gene 9631
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 674842
VEGA: 11
Lrfn4
Name: leucine rich repeat and fibronectin type III domain containing 4
Synonyms: SALM3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225875
Homologene: 36415
Mmp27
Name: matrix metallopeptidase 27
Synonyms: LOC234911
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234911
Homologene: 23345
Kif13a
Name: kinesin family member 13A
Synonyms: 4930505I07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Gsk3a
Name: glycogen synthase kinase 3 alpha
Synonyms: 2700086H06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 606496
HGNC: HGNC:4616
Homologene: 88581
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: Vdu1, 9830169D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170822
Homologene: 8996
Mtx3
Name: metaxin 3
Synonyms: Gm6514, 4930470O13Rik, LOC382793
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 382793
VEGA: 13
Homologene: 46611
Tmem41a
Name: transmembrane protein 41a
Synonyms: 5730578N08Rik, 2900010K02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66664
VEGA: 16
Homologene: 41643
Ngfr
Name: nerve growth factor receptor (TNFR superfamily, member 16)
Synonyms: p75, p75 neurotrophin receptor, LNGFR, p75NTR, p75NGFR, Tnfrsf16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18053
HGNC: HGNC:7809
Homologene: 1877
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: alpha3(IV), tumstatin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Btbd16
Name: BTB domain containing 16
Synonyms: E330040A16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330660
Homologene: 77327
Insc
Name: INSC spindle orientation adaptor protein
Synonyms: 3830422K02Rik, Inscuteable
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233752
Homologene: 78662
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC382129, LOC234973, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Liph
Name: lipase, member H
Synonyms: Lpdlr, C130037N08Rik, D16Wsu119e, LPDLR, PLA1B, mPA-PLA1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: SM1, smMHC, SM2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211936
Homologene: 52235
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9630046L06Rik, 9430004C13Rik, 1110061O17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Or8b37
Name: olfactory receptor family 8 subfamily B member 37
Synonyms: MOR162-11P, Olfr884, MOR162-11P, MOR162-9P, GA_x6K02T2PVTD-31726544-31727473, Olfr1550-ps1, MOR162-13
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257996
Homologene: 79400
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: 2410089E03Rik, Jbts17, Hug, b2b012Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Ptchd3
Name: patched domain containing 3
Synonyms: 4930451E13Rik, 4933440L20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74675
Homologene: 111041
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Or8b57
Name: olfactory receptor family 8 subfamily B member 57
Synonyms: Olfr983, MOR162-1, GA_x6K02T2PVTD-33790948-33790013
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258824
VEGA: 9
Homologene: 121547
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209590
Homologene: 16930
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Ube2m
Name: ubiquitin-conjugating enzyme E2M
Synonyms: Ubc-rs2, UBC12, 2510040H03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22192
Homologene: 2952
Pomgnt2
Name: protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2
Synonyms: Gtdc2, C85492
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215494
VEGA: 9
Homologene: 32795
Sh3pxd2b
Name: SH3 and PX domains 2B
Synonyms: Tks4, G431001E03Rik, Fad49
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268396
Homologene: 27952
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Gp1ba
Name: glycoprotein 1b, alpha polypeptide
Synonyms: GPIba, GP Ib-alpha, GPIb-alpha
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14723
HGNC: HGNC:4439
Homologene: 143
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319719
Homologene: 131217
H2-M1
Name: histocompatibility 2, M region locus 1
Synonyms: Mb1, H-2M1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224756
Homologene: 110792
Atp8a1
Name: ATPase phospholipid transporting 8A1
Synonyms: B230107D19Rik, Atp3a2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11980
Homologene: 48402
Mrm1
Name: mitochondrial rRNA methyltransferase 1
Synonyms: A530065E19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217038
Homologene: 40307
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: EC1-VR2, V2rf2, pheromone recepter
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627569
Homologene: 129606
Lpar2
Name: lysophosphatidic acid receptor 2
Synonyms: LPA2, Edg4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 53978
VEGA: 8
HGNC: HGNC:3168
Homologene: 3465
Necab2
Name: N-terminal EF-hand calcium binding protein 2
Synonyms: Efcbp2, Necab2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 117148
Homologene: 62200
Man2b2
Name: mannosidase 2, alpha B2
Synonyms: 135 kDa alpha-D-mannosidase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17160
Homologene: 7411
Phospho2
Name: phosphatase, orphan 2
Synonyms: 1700048E23Rik, Phos2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73373
Homologene: 41756
4930438A08Rik
Name: RIKEN cDNA 4930438A08 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73988
Homologene: 104884
Hesx1
Name: homeobox gene expressed in ES cells
Synonyms: Rpx, HES-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15209
HGNC: HGNC:4877
Homologene: 20831
Arhgef37
Name: Rho guanine nucleotide exchange factor 37
Synonyms: 4933429F08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328967
VEGA: 18
Homologene: 28467
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,811,838 bp
  • T to C, chromosome 1 at 82,652,158 bp
  • T to C, chromosome 2 at 12,191,242 bp
  • T to A, chromosome 2 at 69,796,196 bp
  • T to A, chromosome 2 at 104,973,154 bp
  • T to C, chromosome 2 at 122,084,983 bp
  • T to C, chromosome 2 at 129,285,716 bp
  • A to G, chromosome 3 at 116,752,176 bp
  • A to G, chromosome 3 at 152,380,574 bp
  • A to G, chromosome 5 at 30,394,697 bp
  • A to T, chromosome 5 at 36,826,058 bp
  • A to T, chromosome 5 at 67,774,725 bp
  • A to T, chromosome 5 at 109,090,507 bp
  • T to A, chromosome 6 at 67,486,333 bp
  • G to T, chromosome 6 at 120,758,198 bp
  • T to A, chromosome 7 at 13,037,626 bp
  • A to G, chromosome 7 at 25,231,709 bp
  • A to T, chromosome 7 at 28,329,037 bp
  • T to A, chromosome 7 at 114,845,077 bp
  • T to A, chromosome 7 at 130,788,827 bp
  • T to C, chromosome 8 at 69,824,173 bp
  • G to A, chromosome 8 at 94,329,433 bp
  • A to G, chromosome 8 at 119,470,931 bp
  • T to C, chromosome 9 at 7,581,155 bp
  • T to C, chromosome 9 at 16,375,123 bp
  • G to T, chromosome 9 at 38,047,827 bp
  • A to G, chromosome 9 at 40,092,511 bp
  • T to A, chromosome 9 at 121,982,061 bp
  • T to A, chromosome 10 at 79,268,600 bp
  • A to G, chromosome 11 at 32,423,341 bp
  • A to G, chromosome 11 at 58,288,350 bp
  • G to T, chromosome 11 at 59,050,480 bp
  • A to G, chromosome 11 at 62,276,647 bp
  • A to G, chromosome 11 at 66,081,248 bp
  • A to G, chromosome 11 at 70,640,788 bp
  • A to G, chromosome 11 at 84,814,813 bp
  • A to G, chromosome 11 at 95,574,239 bp
  • T to C, chromosome 11 at 104,720,880 bp
  • A to G, chromosome 11 at 119,441,150 bp
  • A to G, chromosome 11 at 121,831,158 bp
  • C to A, chromosome 11 at 121,942,502 bp
  • T to A, chromosome 13 at 46,812,823 bp
  • G to T, chromosome 13 at 54,525,655 bp
  • C to T, chromosome 13 at 68,888,042 bp
  • T to C, chromosome 13 at 92,850,361 bp
  • T to A, chromosome 14 at 27,000,852 bp
  • T to A, chromosome 15 at 8,223,092 bp
  • A to T, chromosome 16 at 14,226,616 bp
  • G to T, chromosome 16 at 21,937,990 bp
  • A to G, chromosome 16 at 21,995,350 bp
  • T to A, chromosome 16 at 33,241,730 bp
  • T to A, chromosome 17 at 36,670,228 bp
  • A to G, chromosome 18 at 9,212,947 bp
  • G to T, chromosome 18 at 61,508,789 bp
  • A to G, chromosome 18 at 82,987,263 bp
  • T to A, chromosome 19 at 4,612,640 bp
  • A to G, chromosome 19 at 32,016,776 bp
  • T to C, chromosome 19 at 56,357,325 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0715 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038898-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.