Beutler Mutagenetix

Strain Name:
C57BL/6J-MtgxR0722Btlr/Mmmh
Stock Number:
038904-MU
Citation ID:
RRID:MMRRC_038904-MU
Other Names:
R0722 (G1), C57BL/6J-MtgxR0722Btlr
Major Collection:

Gene Information

Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20562
Homologene: 2302
Spidr
Name: scaffolding protein involved in DNA repair
Synonyms: 2310008H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224008
VEGA: 16
Homologene: 51693
Herc4
Name: hect domain and RLD 4
Synonyms: 4921531D01Rik, 9530080M15Rik, 1700056O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67345
VEGA: 10
Homologene: 56715
Brd4
Name: bromodomain containing 4
Synonyms: HUNK1, WI-11513, MCAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57261
Homologene: 136213
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
9030025P20Rik
Name: RIKEN cDNA 9030025P20 gene
Synonyms: D17Zt9e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100041574
VEGA: 17
HGNC: null
Homologene: 104886
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235469
Homologene: 17151
Ptbp2
Name: polypyrimidine tract binding protein 2
Synonyms: brPTB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56195
Homologene: 23162
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 217995
VEGA: 13
Homologene: 34562
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, 5230400C17Rik, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18711
Homologene: 32115
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226026
VEGA: 19
Homologene: 41009
Cd320
Name: CD320 antigen
Synonyms: NG29, VLDL, 425O18-1, 8D6, D17Ertd716e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 54219
Homologene: 9573
Htr1f
Name: 5-hydroxytryptamine (serotonin) receptor 1F
Synonyms: Htr1eb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 15557
VEGA: 16
HGNC: HGNC:5292
Homologene: 37361
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: bc, small conductance calcium-activated potassium channel 2, SK2, fri
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
Zfp738
Name: zinc finger protein 738
Synonyms: 3830402I07Rik, 6720487G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 408068
Homologene: 133713
Susd1
Name: sushi domain containing 1
Synonyms: Gm12528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 634731
Homologene: 11204
Ccbe1
Name: collagen and calcium binding EGF domains 1
Synonyms: 4933426F18Rik, 9430093N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 320924
Homologene: 15852
Crtam
Name: cytotoxic and regulatory T cell molecule
Synonyms: class I-restricted T cell-associated molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 54698
Homologene: 10454
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: CI-MPR, M6P/IGF2R, Mpr300, mannose-6-phosphate receptor, cation independent, CD222, IGF-II/CI-MPR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Polr2c
Name: polymerase (RNA) II (DNA directed) polypeptide C
Synonyms: RPB3, Rpo2-3, 33kDa, mRBP31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20021
HGNC: HGNC:9189
Homologene: 2017
Tepsin
Name: TEPSIN, adaptor related protein complex 4 accessory protein
Synonyms: Enthd2, 2410002I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78777
Homologene: 35359
Lrrc8c
Name: leucine rich repeat containing 8 family, member C
Synonyms: E430036I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100604
Homologene: 12997
Pkp2
Name: plakophilin 2
Synonyms: Pkp2l, 1200012P04Rik, 1200008D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67451
HGNC: HGNC:9024
Homologene: 3364
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, Hch, CED-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Bmper
Name: BMP-binding endothelial regulator
Synonyms: CV-2, Crim3, Cv2, 3110056H04Rik, crossveinless-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 73230
VEGA: 9
Homologene: 12494
Atp10a
Name: ATPase, class V, type 10A
Synonyms: pfatp, Atp10c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11982
Homologene: 56461
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 269023
VEGA: 18
Homologene: 18485
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: AS250, RGC2, A230067G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241694
Homologene: 28131
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 212517
Homologene: 75085
Gm10840
Name: predicted gene 10840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: null
VEGA: null
HGNC: null
Homologene: null
Akr1c13
Name: aldo-keto reductase family 1, member C13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 27384
HGNC: null
Homologene: 121208
Ppp1r16a
Name: protein phosphatase 1, regulatory subunit 16A
Synonyms: R75527, 2900084E10Rik, Mypt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 73062
Homologene: 13161
Wdr66
Name: WD repeat domain 66
Synonyms: 4930415N18Rik, 4933428F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269701
Homologene: 16964
Pld5
Name: phospholipase D family, member 5
Synonyms: B230365F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 319455
Homologene: 16081
Krt13
Name: keratin 13
Synonyms: K13, Krt1-13, Krt-1.13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16663
HGNC: HGNC:6415
Homologene: 40740
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 319734
Homologene: 26544
Adap2
Name: ArfGAP with dual PH domains 2
Synonyms: centaurin alpha 2, Centa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216991
Homologene: 10179
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 57748
VEGA: 13
Homologene: 10955
Zfp267
Name: zinc finger protein 267
Synonyms: D3Ertd254e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 241944
Homologene: 117700
Pgm2
Name: phosphoglucomutase 2
Synonyms: 3230402E02Rik, Pgm1, Pgm-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66681
HGNC: HGNC:8906
Homologene: 6693
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 620697
HGNC: null
Homologene: 115466
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: BC026439, OAT-PG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 210463
HGNC: null
Homologene: 18166
AC110527.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Lrrc8b
Name: leucine rich repeat containing 8 family, member B
Synonyms: 2210408K08Rik, R75581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 433926
Homologene: 9103
Prr5l
Name: proline rich 5 like
Synonyms: 2600010E01Rik, 4833411O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 72446
Homologene: 11753
Olfr478
Name: olfactory receptor 478
Synonyms: GA_x6K02T2PBJ9-10361879-10360935, MOR204-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258729
HGNC: null
Homologene: 128076
Rassf2
Name: Ras association (RalGDS/AF-6) domain family member 2
Synonyms: 9030412M04Rik, 3830431H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 215653
HGNC: HGNC:9883
Homologene: 22840
Pcna
Name: proliferating cell nuclear antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18538
HGNC: HGNC:8729
Homologene: 1945
Dcst1
Name: DC-STAMP domain containing 1
Synonyms: A330106H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 77772
Homologene: 14981
Ccdc28b
Name: coiled coil domain containing 28B
Synonyms: 1110002E08Rik, 1810010N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66264
Homologene: 11509
Plekhb1
Name: pleckstrin homology domain containing, family B (evectins) member 1
Synonyms: PHR1, evt-1, Phret1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 27276
Homologene: 8449
Olfr981
Name: olfactory receptor 981
Synonyms: GA_x6K02T2PVTD-33720892-33721824, MOR223-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258283
VEGA: 9
HGNC: null
Homologene: 64849
Vtn
Name: vitronectin
Synonyms: Vn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22370
Homologene: 532
Clpp
Name: caseinolytic mitochondrial matrix peptidase proteolytic subunit
Synonyms: D17Wsu160e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 53895
VEGA: 17
HGNC: HGNC:2084
Homologene: 4385
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 65,253,523 bp
  • T to A, chromosome 1 at 141,256,860 bp
  • A to G, chromosome 1 at 175,975,515 bp
  • A to G, chromosome 2 at 101,717,474 bp
  • A to G, chromosome 2 at 132,002,910 bp
  • A to G, chromosome 2 at 132,251,235 bp
  • A to G, chromosome 2 at 146,388,531 bp
  • C to T, chromosome 3 at 36,165,069 bp
  • T to C, chromosome 3 at 86,605,989 bp
  • C to T, chromosome 3 at 89,353,805 bp
  • C to T, chromosome 3 at 119,720,921 bp
  • A to G, chromosome 4 at 59,379,749 bp
  • T to A, chromosome 4 at 129,621,152 bp
  • A to T, chromosome 5 at 64,107,679 bp
  • T to C, chromosome 5 at 105,480,112 bp
  • T to A, chromosome 5 at 105,579,548 bp
  • T to A, chromosome 5 at 123,256,185 bp
  • C to T, chromosome 6 at 119,307,286 bp
  • A to G, chromosome 7 at 58,816,183 bp
  • A to T, chromosome 7 at 85,221,586 bp
  • A to T, chromosome 7 at 100,645,603 bp
  • A to G, chromosome 7 at 108,032,334 bp
  • T to A, chromosome 8 at 94,862,637 bp
  • G to T, chromosome 9 at 23,373,928 bp
  • A to G, chromosome 9 at 40,022,999 bp
  • A to T, chromosome 9 at 40,992,616 bp
  • T to G, chromosome 9 at 72,312,101 bp
  • A to G, chromosome 10 at 63,286,065 bp
  • A to T, chromosome 11 at 34,464,970 bp
  • A to G, chromosome 11 at 78,500,854 bp
  • T to C, chromosome 11 at 80,156,984 bp
  • T to G, chromosome 11 at 100,119,153 bp
  • A to G, chromosome 11 at 106,161,076 bp
  • A to G, chromosome 11 at 120,095,337 bp
  • A to G, chromosome 13 at 4,197,932 bp
  • A to G, chromosome 13 at 12,406,037 bp
  • A to T, chromosome 13 at 67,671,524 bp
  • G to A, chromosome 13 at 93,452,817 bp
  • T to C, chromosome 15 at 57,256,553 bp
  • C to T, chromosome 15 at 76,693,669 bp
  • A to G, chromosome 16 at 15,912,781 bp
  • T to C, chromosome 16 at 16,247,028 bp
  • G to A, chromosome 16 at 44,404,676 bp
  • A to G, chromosome 16 at 64,925,891 bp
  • T to C, chromosome 17 at 12,715,495 bp
  • A to G, chromosome 17 at 15,022,128 bp
  • T to C, chromosome 17 at 32,212,982 bp
  • T to C, chromosome 17 at 33,846,030 bp
  • T to C, chromosome 17 at 56,992,901 bp
  • T to C, chromosome 18 at 45,559,476 bp
  • T to G, chromosome 18 at 54,900,234 bp
  • C to T, chromosome 18 at 66,084,806 bp
  • C to A, chromosome 19 at 23,208,927 bp
  • T to C, chromosome 19 at 41,608,435 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0722 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038904-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.