Strain Name:
C57BL/6J-MtgxR0730Btlr/Mmmh
Stock Number:
038911-MU
Citation ID:
RRID:MMRRC_038911-MU
Other Names:
R0730 (G1), C57BL/6J-MtgxR0730Btlr
Major Collection:

Gene Information

Gene Symbol: Adamts20 (Mus musculus (mouse))
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: ADAMTS-20, bt
Chromosome: 15
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:2660628
Gene Symbol: Utrn (Mus musculus (mouse))
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Chromosome: 10
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:104631
Gene Symbol: Rptor (Mus musculus (mouse))
Name: regulatory associated protein of MTOR, complex 1
Synonyms: Rap, 4932417H02Rik, raptor
Chromosome: 11
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:1921620
Gene Symbol: Erbb4 (Mus musculus (mouse))
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Chromosome: 1
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:104771
Gene Symbol: App (Mus musculus (mouse))
Name: amyloid beta (A4) precursor protein
Synonyms: Adap, Cvap, appican, betaAPP, E030013M08Rik, Abeta, protease nexin II
Chromosome: 16
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:88059
Gene Symbol: Macf1 (Mus musculus (mouse))
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Aclp7, Acf7
Chromosome: 4
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:108559
Gene Symbol: Rictor (Mus musculus (mouse))
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, 4921505C17Rik, D530039E11Rik
Chromosome: 15
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:1926007
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 4,777,611 bp
  • A to T, chromosome 1 at 53,061,794 bp
  • G to A, chromosome 1 at 58,414,399 bp
  • A to G, chromosome 1 at 68,259,290 bp
  • A to C, chromosome 1 at 85,577,036 bp
  • A to G, chromosome 1 at 150,393,407 bp
  • G to A, chromosome 1 at 169,995,566 bp
  • G to A, chromosome 1 at 172,240,207 bp
  • T to A, chromosome 2 at 25,504,618 bp
  • A to G, chromosome 2 at 86,198,725 bp
  • T to C, chromosome 2 at 87,049,148 bp
  • G to A, chromosome 2 at 121,432,377 bp
  • C to T, chromosome 2 at 142,217,674 bp
  • T to A, chromosome 3 at 108,398,606 bp
  • T to A, chromosome 3 at 108,469,535 bp
  • T to A, chromosome 3 at 133,137,471 bp
  • G to A, chromosome 4 at 34,711,391 bp
  • C to T, chromosome 4 at 116,985,746 bp
  • T to C, chromosome 4 at 118,612,920 bp
  • A to G, chromosome 4 at 123,382,530 bp
  • A to T, chromosome 4 at 134,008,008 bp
  • A to G, chromosome 4 at 152,347,984 bp
  • G to A, chromosome 5 at 87,694,952 bp
  • A to T, chromosome 5 at 134,192,758 bp
  • A to G, chromosome 6 at 5,230,444 bp
  • G to C, chromosome 6 at 97,116,009 bp
  • A to G, chromosome 6 at 97,176,492 bp
  • A to C, chromosome 6 at 106,550,486 bp
  • C to T, chromosome 6 at 118,612,625 bp
  • C to T, chromosome 6 at 124,934,391 bp
  • A to T, chromosome 6 at 129,658,696 bp
  • C to T, chromosome 6 at 134,617,461 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to T, chromosome 6 at 138,147,669 bp
  • T to A, chromosome 7 at 102,160,716 bp
  • T to C, chromosome 8 at 15,099,326 bp
  • A to T, chromosome 8 at 24,996,758 bp
  • G to A, chromosome 8 at 25,555,744 bp
  • C to T, chromosome 8 at 54,693,096 bp
  • T to C, chromosome 8 at 71,656,285 bp
  • T to A, chromosome 8 at 95,344,041 bp
  • T to C, chromosome 8 at 111,125,755 bp
  • A to G, chromosome 8 at 121,555,364 bp
  • T to C, chromosome 8 at 122,891,953 bp
  • C to T, chromosome 8 at 123,949,008 bp
  • A to G, chromosome 9 at 58,359,877 bp
  • T to A, chromosome 9 at 89,951,009 bp
  • G to A, chromosome 9 at 107,679,463 bp
  • T to A, chromosome 9 at 108,106,812 bp
  • A to T, chromosome 9 at 122,861,758 bp
  • T to C, chromosome 10 at 6,832,652 bp
  • A to T, chromosome 10 at 12,698,158 bp
  • A to C, chromosome 10 at 24,092,026 bp
  • A to G, chromosome 10 at 40,844,956 bp
  • T to C, chromosome 10 at 60,323,714 bp
  • C to T, chromosome 10 at 75,895,242 bp
  • C to T, chromosome 10 at 78,796,008 bp
  • T to C, chromosome 10 at 93,034,737 bp
  • A to T, chromosome 10 at 118,294,237 bp
  • T to A, chromosome 10 at 129,945,111 bp
  • C to T, chromosome 11 at 6,520,794 bp
  • T to C, chromosome 11 at 6,676,476 bp
  • A to T, chromosome 11 at 74,084,822 bp
  • A to T, chromosome 11 at 119,884,954 bp
  • T to C, chromosome 12 at 55,665,663 bp
  • T to C, chromosome 12 at 76,204,166 bp
  • A to G, chromosome 12 at 108,530,326 bp
  • T to A, chromosome 12 at 112,112,259 bp
  • A to T, chromosome 13 at 30,381,296 bp
  • T to A, chromosome 13 at 49,378,241 bp
  • C to A, chromosome 13 at 92,521,477 bp
  • G to T, chromosome 13 at 99,429,766 bp
  • G to A, chromosome 13 at 100,058,951 bp
  • G to T, chromosome 13 at 113,213,502 bp
  • T to C, chromosome 14 at 28,982,365 bp
  • T to C, chromosome 14 at 78,584,479 bp
  • A to G, chromosome 15 at 6,773,986 bp
  • T to C, chromosome 15 at 65,995,608 bp
  • A to T, chromosome 15 at 66,678,789 bp
  • G to A, chromosome 15 at 94,347,690 bp
  • A to T, chromosome 15 at 95,920,371 bp
  • C to T, chromosome 15 at 100,171,651 bp
  • A to T, chromosome 15 at 101,887,349 bp
  • A to G, chromosome 16 at 18,814,887 bp
  • A to G, chromosome 16 at 85,079,952 bp
  • A to G, chromosome 17 at 35,014,300 bp
  • A to T, chromosome 17 at 71,496,246 bp
  • T to C, chromosome 18 at 12,219,325 bp
  • C to A, chromosome 18 at 12,456,850 bp
  • C to T, chromosome 18 at 31,835,376 bp
  • A to T, chromosome 18 at 35,978,574 bp
  • C to A, chromosome 18 at 37,448,868 bp
  • A to T, chromosome 18 at 75,565,012 bp
  • T to A, chromosome 18 at 80,450,242 bp
  • A to G, chromosome 18 at 82,640,244 bp
  • C to T, chromosome 19 at 18,604,207 bp
  • T to A, chromosome 19 at 29,717,981 bp
  • G to A, chromosome 19 at 38,716,691 bp
  • C to A, chromosome X at 161,837,300 bp
  • C to T, chromosome X at 164,948,257 bp
Genotype Determination
ES Cell Line
N/A
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
MeSH Terms
    Strain Development
    C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
    Suggested Control Mice
    Wild-type littermates or C57BL/6J mice
    Primary Reference
    MUTAGENETIX record for R0730 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
    Coat Color
    Black
    MMRRC Breeding System
    Random intra-strain mating
    Breeding Scheme(s)
    When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
    Overall Breeding Performance
    Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
    Average litter size
    Undetermined
    Recommended wean age
    3 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    038911-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.