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Strain Name:
C57BL/6J-MtgxR0732Btlr/Mmmh
Stock Number:
038913-MU
Citation ID:
RRID:MMRRC_038913-MU
Other Names:
R0732 (G1), C57BL/6J-MtgxR0732Btlr
Major Collection:

Strain Information

Tnpo1
Name: transportin 1
Synonyms: D13Ertd688e, Kpnb2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238799
HGNC: HGNC:6401
Homologene: 5358
Wnt5b
Name: wingless-type MMTV integration site family, member 5B
Synonyms: Wnt-5b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22419
Homologene: 22530
Arc
Name: activity regulated cytoskeletal-associated protein
Synonyms: Arc3.1, arg 3.1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11838
HGNC: HGNC:648
Homologene: 9056
Atf2
Name: activating transcription factor 2
Synonyms: mXBP, CRE-BP, Creb2, D130078H02Rik, ATF-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Mthfd1
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Synonyms: Mthfd, DCS, E430024A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108156
VEGA: 12
HGNC: HGNC:7432
Homologene: 55940
Exoc6b
Name: exocyst complex component 6B
Synonyms: 4930569O18Rik, G430127E12Rik, Sec15b, Sec15l2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75914
Homologene: 44781
Taf8
Name: TATA-box binding protein associated factor 8
Synonyms: Taf8, Tbn
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63856
VEGA: 17
Homologene: 11094
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 14,880,189 bp
  • A to G, chromosome 1 at 34,470,350 bp
  • A to G, chromosome 1 at 38,092,057 bp
  • A to G, chromosome 1 at 57,411,835 bp
  • A to G, chromosome 1 at 97,740,657 bp
  • A to T, chromosome 1 at 174,137,415 bp
  • T to C, chromosome 2 at 18,046,157 bp
  • T to G, chromosome 2 at 22,901,312 bp
  • T to A, chromosome 2 at 30,973,937 bp
  • T to C, chromosome 2 at 52,258,681 bp
  • T to C, chromosome 2 at 52,291,268 bp
  • A to T, chromosome 2 at 73,845,500 bp
  • A to C, chromosome 2 at 86,085,584 bp
  • A to G, chromosome 2 at 90,119,322 bp
  • T to A, chromosome 2 at 111,306,980 bp
  • A to G, chromosome 2 at 112,242,695 bp
  • A to T, chromosome 2 at 119,271,014 bp
  • T to C, chromosome 2 at 121,248,264 bp
  • A to G, chromosome 2 at 126,917,299 bp
  • T to A, chromosome 3 at 55,190,373 bp
  • C to T, chromosome 3 at 89,148,786 bp
  • T to A, chromosome 3 at 142,606,978 bp
  • T to C, chromosome 4 at 117,675,419 bp
  • G to A, chromosome 4 at 123,105,406 bp
  • T to A, chromosome 4 at 151,586,484 bp
  • T to C, chromosome 5 at 3,713,163 bp
  • T to C, chromosome 5 at 24,590,421 bp
  • C to A, chromosome 5 at 57,721,315 bp
  • A to T, chromosome 5 at 87,460,639 bp
  • G to T, chromosome 5 at 97,960,708 bp
  • A to T, chromosome 5 at 104,467,005 bp
  • G to C, chromosome 5 at 109,557,138 bp
  • T to A, chromosome 5 at 110,858,435 bp
  • T to C, chromosome 6 at 34,390,109 bp
  • A to G, chromosome 6 at 49,417,495 bp
  • T to A, chromosome 6 at 56,878,104 bp
  • T to C, chromosome 6 at 66,553,706 bp
  • A to T, chromosome 6 at 71,881,171 bp
  • T to A, chromosome 6 at 82,552,901 bp
  • C to A, chromosome 6 at 84,855,522 bp
  • C to T, chromosome 6 at 119,446,582 bp
  • T to C, chromosome 6 at 128,546,448 bp
  • T to C, chromosome 7 at 29,535,409 bp
  • C to T, chromosome 7 at 29,700,696 bp
  • T to G, chromosome 7 at 50,856,387 bp
  • T to C, chromosome 7 at 55,886,781 bp
  • T to C, chromosome 7 at 85,410,430 bp
  • T to C, chromosome 7 at 102,484,443 bp
  • T to C, chromosome 7 at 104,106,294 bp
  • C to A, chromosome 7 at 108,422,577 bp
  • A to T, chromosome 7 at 116,145,237 bp
  • T to C, chromosome 7 at 119,773,834 bp
  • T to C, chromosome 7 at 132,871,651 bp
  • T to A, chromosome 7 at 143,781,566 bp
  • T to A, chromosome 7 at 144,619,488 bp
  • T to C, chromosome 8 at 25,741,321 bp
  • T to A, chromosome 8 at 56,591,529 bp
  • C to T, chromosome 8 at 84,676,201 bp
  • A to T, chromosome 8 at 109,948,483 bp
  • T to A, chromosome 9 at 76,492,928 bp
  • T to A, chromosome 9 at 77,001,654 bp
  • T to C, chromosome 10 at 4,450,636 bp
  • C to T, chromosome 10 at 34,060,009 bp
  • T to A, chromosome 10 at 75,817,321 bp
  • T to C, chromosome 10 at 77,883,434 bp
  • T to A, chromosome 10 at 81,258,306 bp
  • T to A, chromosome 10 at 81,512,556 bp
  • T to C, chromosome 10 at 121,750,947 bp
  • G to A, chromosome 10 at 128,387,583 bp
  • C to T, chromosome 11 at 6,620,812 bp
  • T to C, chromosome 11 at 53,375,596 bp
  • T to A, chromosome 11 at 62,458,481 bp
  • G to T, chromosome 11 at 70,455,408 bp
  • T to C, chromosome 11 at 103,619,838 bp
  • T to A, chromosome 11 at 110,163,390 bp
  • A to T, chromosome 11 at 119,441,068 bp
  • T to C, chromosome 12 at 11,290,817 bp
  • A to T, chromosome 12 at 28,599,040 bp
  • T to A, chromosome 12 at 51,595,372 bp
  • T to A, chromosome 12 at 76,294,174 bp
  • C to T, chromosome 12 at 113,140,558 bp
  • T to C, chromosome 13 at 81,503,004 bp
  • C to T, chromosome 13 at 98,863,812 bp
  • T to C, chromosome 14 at 30,042,920 bp
  • T to G, chromosome 14 at 30,571,140 bp
  • A to G, chromosome 14 at 66,086,963 bp
  • T to C, chromosome 14 at 68,637,347 bp
  • T to A, chromosome 14 at 77,091,759 bp
  • T to C, chromosome 15 at 58,442,817 bp
  • G to A, chromosome 15 at 74,671,195 bp
  • A to G, chromosome 15 at 76,248,758 bp
  • A to G, chromosome 15 at 82,852,303 bp
  • T to C, chromosome 15 at 98,457,078 bp
  • G to T, chromosome 15 at 101,560,425 bp
  • T to C, chromosome 15 at 102,665,045 bp
  • C to T, chromosome 15 at 103,533,087 bp
  • A to G, chromosome 17 at 12,841,747 bp
  • T to A, chromosome 17 at 26,954,988 bp
  • G to T, chromosome 17 at 31,625,029 bp
  • A to C, chromosome 17 at 35,044,019 bp
  • C to T, chromosome 17 at 35,825,524 bp
  • T to A, chromosome 17 at 36,852,618 bp
  • C to T, chromosome 17 at 46,724,700 bp
  • C to T, chromosome 17 at 47,498,525 bp
  • A to G, chromosome 17 at 80,381,354 bp
  • A to T, chromosome 18 at 40,258,563 bp
  • A to T, chromosome 19 at 3,897,866 bp
  • C to T, chromosome 19 at 10,723,285 bp
  • C to T, chromosome 19 at 23,378,869 bp
  • T to C, chromosome 19 at 43,666,953 bp
  • T to A, chromosome 19 at 46,514,739 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0732 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038913-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.