Strain Name:
C57BL/6J-MtgxR0742Btlr/Mmmh
Stock Number:
038923-MU
Citation ID:
RRID:MMRRC_038923-MU
Other Names:
R0742 (G1), C57BL/6J-MtgxR0742Btlr
Major Collection:

Gene Information

Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, A930013E17Rik, Zap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56531
Homologene: 87707
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: Usp31, 2810449C13Rik, D330022K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 170707
Homologene: 12988
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, 2610202A04Rik, D16Ium21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 22129
Homologene: 2487
Rev1
Name: REV1, DNA directed polymerase
Synonyms: 1110027I23Rik, REV1, Rev1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 56210
Homologene: 32309
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: Walp3, Tip5, C030005G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103573
Homologene: 2554
Cct2
Name: chaperonin containing Tcp1, subunit 2 (beta)
Synonyms: Cctb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12461
VEGA: 10
HGNC: HGNC:1615
Homologene: 4696
Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Synonyms: Bcrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 26357
HGNC: HGNC:74
Homologene: 55852
Cdc42bpg
Name: CDC42 binding protein kinase gamma (DMPK-like)
Synonyms: MRCKgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 240505
Homologene: 28384
Bsx
Name: brain specific homeobox
Synonyms: Bsx1a, Bsx1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244813
Homologene: 65347
Twf1
Name: twinfilin actin binding protein 1
Synonyms: actin monomer-binding protein, Twinfilin-1, twinfilin, Ptk9, A6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 19230
HGNC: HGNC:9620
Homologene: 48140
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 2310042E16Rik, Coh1, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Plec
Name: plectin
Synonyms: Plec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18810
HGNC: HGNC:9069
Homologene: 384
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329252
Homologene: 49680
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20743
VEGA: 19
Homologene: 48482
Copg2
Name: coatomer protein complex, subunit gamma 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 54160
HGNC: HGNC:2237
Homologene: 56292
Ddx17
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
Synonyms: LOC381024, 2610007K22Rik, A430025E01Rik, p72
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 67040
VEGA: 15
HGNC: HGNC:2740
Homologene: 101101
Steap3
Name: STEAP family member 3
Synonyms: pHyde, 1010001D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68428
Homologene: 10084
Pcdh15
Name: protocadherin 15
Synonyms: roda, nmf19, Ush1f, Gm9815
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11994
Homologene: 23401
Fyb
Name: FYN binding protein
Synonyms: ADAP, FYB-120/130, B630013F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 23880
HGNC: HGNC:4036
Homologene: 22664
Aff3
Name: AF4/FMR2 family, member 3
Synonyms: 3222402O04Rik, Laf4, LAF-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16764
HGNC: HGNC:6473
Homologene: 1718
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: A930038D23Rik, Ae3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20536
Homologene: 129474
Unc80
Name: unc-80, NALCN activator
Synonyms: C030018G13Rik, C230061B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329178
Homologene: 122243
Scap
Name: SREBF chaperone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235623
Homologene: 8160
Arhgef10l
Name: Rho guanine nucleotide exchange factor (GEF) 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72754
Homologene: 10017
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 628870
Homologene: 46008
Mroh3
Name: maestro heat-like repeat family member 3
Synonyms: 2310006M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 76422
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
4930449E01Rik
Name: RIKEN cDNA 4930449E01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 74864
Akr1d1
Name: aldo-keto reductase family 1, member D1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 208665
HGNC: HGNC:388
Homologene: 55943
Tmprss13
Name: transmembrane protease, serine 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 214531
Homologene: 12936
Aldh3b2
Name: aldehyde dehydrogenase 3 family, member B2
Synonyms: C130048D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 621603
HGNC: HGNC:411
Homologene: 84430
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100042165
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382105
Homologene: 110776
Pygm
Name: muscle glycogen phosphorylase
Synonyms: PG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 19309
HGNC: HGNC:9726
Homologene: 2145
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 627569
Homologene: 129606
Sec61a2
Name: Sec61, alpha subunit 2 (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 57743
Homologene: 38481
Rpe
Name: ribulose-5-phosphate-3-epimerase
Synonyms: 2810429B02Rik, 5730518J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66646
Homologene: 12005
Abca7
Name: ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms: Abc51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Lyz1
Name: lysozyme 1
Synonyms: renal amyloidosis, Lzp-s, Lyz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17110
VEGA: 10
HGNC: HGNC:6740
Homologene: 121490
Casd1
Name: CAS1 domain containing 1
Synonyms: Cast1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 213819
Homologene: 11287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 38,059,117 bp
  • A to G, chromosome 1 at 38,627,108 bp
  • A to G, chromosome 1 at 66,527,893 bp
  • C to T, chromosome 1 at 66,715,141 bp
  • T to C, chromosome 1 at 74,146,716 bp
  • T to A, chromosome 1 at 75,556,081 bp
  • C to T, chromosome 1 at 120,241,583 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • A to T, chromosome 1 at 136,190,980 bp
  • T to C, chromosome 2 at 5,876,548 bp
  • T to A, chromosome 4 at 137,652,945 bp
  • A to G, chromosome 4 at 140,536,845 bp
  • G to A, chromosome 5 at 104,522,154 bp
  • T to A, chromosome 5 at 109,086,415 bp
  • T to C, chromosome 6 at 4,635,888 bp
  • T to C, chromosome 6 at 30,863,613 bp
  • T to C, chromosome 6 at 37,530,343 bp
  • T to A, chromosome 6 at 58,678,326 bp
  • A to G, chromosome 9 at 40,876,500 bp
  • T to C, chromosome 9 at 45,332,467 bp
  • C to T, chromosome 9 at 109,555,556 bp
  • T to A, chromosome 9 at 110,381,259 bp
  • A to G, chromosome 10 at 74,621,297 bp
  • T to A, chromosome 10 at 80,002,821 bp
  • A to G, chromosome 10 at 107,866,740 bp
  • A to T, chromosome 10 at 117,055,246 bp
  • A to T, chromosome 10 at 117,289,117 bp
  • G to T, chromosome 10 at 128,113,666 bp
  • T to C, chromosome 11 at 23,294,682 bp
  • T to A, chromosome 12 at 85,029,112 bp
  • C to T, chromosome 14 at 105,499,033 bp
  • A to G, chromosome 15 at 6,634,816 bp
  • A to G, chromosome 15 at 35,794,361 bp
  • A to T, chromosome 15 at 76,172,783 bp
  • A to G, chromosome 15 at 79,537,557 bp
  • A to G, chromosome 15 at 94,585,530 bp
  • G to A, chromosome 16 at 94,459,880 bp
  • G to A, chromosome 19 at 3,981,034 bp
  • T to C, chromosome 19 at 4,718,983 bp
  • G to A, chromosome 19 at 6,318,575 bp
  • T to C, chromosome 19 at 6,390,931 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0742 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038923-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.