Strain Name:
C57BL/6J-MtgxR0745Btlr/Mmmh
Stock Number:
038926-MU
Citation ID:
RRID:MMRRC_038926-MU
Other Names:
R0745 (G1), C57BL/6J-MtgxR0745Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, Mll3, E330008K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Gabra6
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
Synonyms: Gabra-6, GABA-ARalpha6, alpha6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14399
HGNC: HGNC:4080
Homologene: 20220
Tgfa
Name: transforming growth factor alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21802
Homologene: 2431
Trmo
Name: tRNA methyltransferase O
Synonyms: 5830415F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74753
Homologene: 32316
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Her-2 Tg, Aprin, WAP-Her-2, Tg(Wap-ERBB2)229Wzw
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100710
Homologene: 41001
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Sik3
Name: SIK family kinase 3
Synonyms: 9030204A07Rik, 5730525O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70661
Homologene: 57023
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: Zfp262, 6330503C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67785
Homologene: 35470
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 1810044A24Rik, 2900005P22Rik, Nibp, 4632408O18Rik, TRS130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Tut4
Name: terminal uridylyl transferase 4
Synonyms: Zcchc11, 9230115F04Rik, 6030404K05Rik, Tent3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230594
Homologene: 35279
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Eef2
Name: eukaryotic translation elongation factor 2
Synonyms: Ef-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13629
VEGA: 10
HGNC: HGNC:3214
Homologene: 134867
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4930515K21Rik, 4933435G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98403
Homologene: 9188
Spin1
Name: spindlin 1
Synonyms: Spin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20729
VEGA: 13
Homologene: 55983
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72333
Homologene: 75052
Dlat
Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Synonyms: PDC-E2, 6332404G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: 8430411H09Rik, Pp6r2, Saps2, B230107H12Rik, 1110033O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Uba5
Name: ubiquitin-like modifier activating enzyme 5
Synonyms: 5730525G14Rik, Ube1dc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66663
Homologene: 11738
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Synonyms: 3(beta)HSDV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15496
Homologene: 104115
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Mthfsd
Name: methenyltetrahydrofolate synthetase domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234814
Homologene: 11245
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17836
Homologene: 136663
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Olfr1357
Name: olfactory receptor 1357
Synonyms: MOR128-4, MOR128-3, GA_x6K02T2QGN0-3196801-3197742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 257883
HGNC: HGNC:8207
Homologene: 72920
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 59056
HGNC: HGNC:3497
Homologene: 10949
Abhd12
Name: abhydrolase domain containing 12
Synonyms: 6330583M11Rik, 1500011G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76192
Homologene: 22910
Tcp11
Name: t-complex protein 11
Synonyms: Tcp-11, D17Ken1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21463
Homologene: 8433
Cyp4v3
Name: cytochrome P450, family 4, subfamily v, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102294
Homologene: 133054
Endod1
Name: endonuclease domain containing 1
Synonyms: 2210414F18Rik, 2310067E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71946
VEGA: 9
Homologene: 12425
Tspan17
Name: tetraspanin 17
Synonyms: 2210021G21Rik, Fbxo23, Tm4sf17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74257
Homologene: 41762
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 33,770,848 bp
  • A to G, chromosome 1 at 45,407,227 bp
  • A to T, chromosome 2 at 150,833,148 bp
  • A to G, chromosome 3 at 36,928,463 bp
  • A to G, chromosome 3 at 98,619,539 bp
  • A to G, chromosome 4 at 46,382,104 bp
  • C to G, chromosome 4 at 108,502,955 bp
  • A to T, chromosome 4 at 126,902,703 bp
  • A to T, chromosome 5 at 25,359,698 bp
  • A to T, chromosome 5 at 37,319,059 bp
  • A to G, chromosome 5 at 73,071,126 bp
  • A to T, chromosome 5 at 150,544,882 bp
  • A to G, chromosome 5 at 150,805,671 bp
  • G to A, chromosome 6 at 86,271,435 bp
  • A to G, chromosome 6 at 121,887,427 bp
  • A to G, chromosome 8 at 45,308,651 bp
  • G to A, chromosome 8 at 61,877,703 bp
  • A to T, chromosome 8 at 121,102,949 bp
  • A to T, chromosome 9 at 14,357,117 bp
  • A to G, chromosome 9 at 46,198,239 bp
  • G to A, chromosome 9 at 50,653,708 bp
  • A to G, chromosome 9 at 104,049,511 bp
  • T to C, chromosome 10 at 78,612,122 bp
  • C to T, chromosome 10 at 81,181,996 bp
  • T to A, chromosome 10 at 83,518,630 bp
  • A to T, chromosome 11 at 42,316,567 bp
  • A to G, chromosome 11 at 59,082,239 bp
  • A to G, chromosome 12 at 21,332,221 bp
  • A to G, chromosome 13 at 51,139,515 bp
  • T to C, chromosome 13 at 54,789,674 bp
  • A to T, chromosome 15 at 55,338,417 bp
  • G to A, chromosome 15 at 73,025,967 bp
  • G to A, chromosome 15 at 89,265,242 bp
  • T to C, chromosome 17 at 28,067,160 bp
  • A to C, chromosome 17 at 73,351,508 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0745 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038926-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.