Strain Name:
C57BL/6J-MtgxR0746Btlr/Mmmh
Stock Number:
038927-MU
Citation ID:
RRID:MMRRC_038927-MU
Other Names:
R0746 (G1), C57BL/6J-MtgxR0746Btlr
Major Collection:

Strain Information

Snx2
Name: sorting nexin 2
Synonyms: 0610030A03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67804
VEGA: 18
Homologene: 2332
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: Rbp1l1, 6330417L24Rik, 6720480E17Rik, BRCAA1, SAP180, RBBP1L1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Diaph3
Name: diaphanous related formin 3
Synonyms: Diap3, mDia2, Drf3, 4930417P13Rik, p134MDia2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, Morf, B130044K16Rik, monocytic leukemia, qkf, querkopf
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54169
Homologene: 136480
Bltp3b
Name: bridge-like lipid transfer protein family member 3B
Synonyms: 2010319N22Rik, Uhrf1bp1l, 4930506D01Rik, E030041M21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75089
VEGA: 10
Homologene: 12590
Yars1
Name: tyrosyl-tRNA synthetase 1
Synonyms: Yars
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107271
Homologene: 2730
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Fanci
Name: Fanconi anemia, complementation group I
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 208836
Homologene: 49530
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, 2810406C15Rik, 2810465G24Rik, CAP-D2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68298
Homologene: 6497
Myo1d
Name: myosin ID
Synonyms: D11Ertd9e, 9930104H07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Ilf2
Name: interleukin enhancer binding factor 2
Synonyms: Tex267, 6230405A16Rik, Tex261, TEG-267
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67781
HGNC: HGNC:6037
Homologene: 26894
Cabp7
Name: calcium binding protein 7
Synonyms: calneuron II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192650
Homologene: 16364
Acvr1
Name: activin A receptor, type 1
Synonyms: Alk8, ActRIA, Acvr1a, Alk-2, ActR-I, Tsk7L, SKR1, D330013D15Rik, Acvr, Acvrlk2, ALK2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Cul1
Name: cullin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26965
HGNC: HGNC:2551
Homologene: 2663
Sh3bp5l
Name: SH3 binding domain protein 5 like
Synonyms: 2310074E09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 79566
Homologene: 32584
Cwc22
Name: CWC22 spliceosome-associated protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80744
Homologene: 6048
Rfx7
Name: regulatory factor X, 7
Synonyms: 2510005N23Rik, D130086K05Rik, Rfxdc2, 9930116O05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319758
Homologene: 11275
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67569
Homologene: 8297
Septin5
Name: septin 5
Synonyms: Cdcrel1, Pnutl1, Sept5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18951
VEGA: 16
HGNC: HGNC:9164
Homologene: 74446
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
F7
Name: coagulation factor VII
Synonyms: FVII, Cf7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14068
HGNC: HGNC:3544
Homologene: 7710
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola-2, Col1a-2, Cola2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Wdr11
Name: WD repeat domain 11
Synonyms: Wdr11, Brwd2, 2900055P10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207425
Homologene: 41229
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75820
Homologene: 51634
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MHC2A, Myhs-f, Myhs-f1, Myhsf1, MyHC-IIa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Taar6
Name: trace amine-associated receptor 6
Synonyms: LOC215855
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215855
Homologene: 27874
Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
Synonyms: PTP-NP, phogrin, 4930425H11Rik, IA-2beta, IA-2 beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Kcna2
Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms: Akr6a4, Mk-2, Kv1.2, Kca1-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16490
HGNC: HGNC:6220
Homologene: 21034
Nnt
Name: nicotinamide nucleotide transhydrogenase
Synonyms: 4930423F13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18115
HGNC: HGNC:7863
Adamts10
Name: ADAM metallopeptidase with thrombospondin type 1 motif 10
Synonyms: ZnMP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224697
Homologene: 81940
Ces1d
Name: carboxylesterase 1D
Synonyms: TGH, Ces3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104158
HGNC: HGNC:1863
Homologene: 35606
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: D130067I03Rik, 1700074E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Fam75d3
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
4921513D11Rik
Name: RIKEN cDNA 4921513D11 gene
Type: Gene
Species: Mouse
Chromosome: 17
Prss3b
Name: serine protease 3B
Synonyms: T7, cationic trypsinogen (isoform T7), 2210010C04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67373
Homologene: 134055
Or11h6
Name: olfactory receptor family 11 subfamily H member 6
Synonyms: GA_x6K02T2PMLR-6361495-6362481, Olfr745, MOR106-11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258296
Homologene: 27116
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
B230325K18Rik
Name: RIKEN cDNA B230325K18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Tmem50b
Name: transmembrane protein 50B
Synonyms: B230114J08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77975
HGNC: HGNC:1280
Homologene: 21234
Arhgef37
Name: Rho guanine nucleotide exchange factor 37
Synonyms: 4933429F08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328967
VEGA: 18
Homologene: 28467
Gpr146
Name: G protein-coupled receptor 146
Synonyms: PGR8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80290
Homologene: 36472
Or10ab5
Name: olfactory receptor family 10 subfamily AB member 5
Synonyms: MOR267-14, GA_x6K02T2PBJ9-10976304-10975339, Olfr509
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258369
Homologene: 131128
Tmem115
Name: transmembrane protein 115
Synonyms: Pl6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56395
Homologene: 135207
Mrps10
Name: mitochondrial ribosomal protein S10
Synonyms: 1110038B19Rik, Rpms10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64657
Homologene: 10028
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,198,107 bp
  • C to A, chromosome 1 at 130,188,531 bp
  • A to T, chromosome 1 at 175,792,973 bp
  • T to C, chromosome 2 at 58,500,550 bp
  • T to A, chromosome 2 at 66,351,126 bp
  • T to C, chromosome 2 at 77,904,045 bp
  • T to A, chromosome 3 at 90,482,807 bp
  • A to G, chromosome 3 at 107,105,168 bp
  • C to A, chromosome 4 at 88,397,214 bp
  • C to A, chromosome 4 at 129,197,286 bp
  • C to T, chromosome 5 at 139,393,222 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • C to T, chromosome 6 at 41,032,292 bp
  • T to C, chromosome 6 at 47,518,288 bp
  • T to C, chromosome 6 at 125,174,264 bp
  • T to A, chromosome 7 at 79,439,681 bp
  • A to T, chromosome 7 at 108,646,041 bp
  • A to G, chromosome 7 at 127,985,424 bp
  • T to G, chromosome 7 at 129,632,436 bp
  • T to G, chromosome 8 at 13,034,740 bp
  • A to G, chromosome 8 at 93,189,468 bp
  • A to G, chromosome 9 at 72,619,106 bp
  • C to T, chromosome 9 at 107,537,999 bp
  • C to A, chromosome 10 at 23,985,360 bp
  • T to A, chromosome 10 at 89,805,454 bp
  • T to C, chromosome 10 at 102,388,687 bp
  • A to G, chromosome 10 at 107,517,831 bp
  • A to T, chromosome 11 at 4,738,900 bp
  • A to G, chromosome 11 at 58,346,347 bp
  • A to G, chromosome 11 at 67,173,431 bp
  • A to C, chromosome 11 at 80,586,879 bp
  • T to C, chromosome 12 at 109,592,960 bp
  • A to C, chromosome 12 at 116,901,017 bp
  • A to G, chromosome 13 at 14,143,038 bp
  • C to A, chromosome 13 at 59,702,263 bp
  • G to A, chromosome 13 at 119,368,639 bp
  • T to A, chromosome 14 at 21,637,533 bp
  • T to C, chromosome 14 at 34,822,690 bp
  • T to A, chromosome 14 at 50,642,775 bp
  • T to C, chromosome 14 at 86,985,607 bp
  • T to C, chromosome 16 at 18,623,225 bp
  • C to T, chromosome 16 at 91,581,690 bp
  • T to A, chromosome 17 at 33,549,547 bp
  • A to C, chromosome 17 at 47,372,639 bp
  • A to C, chromosome 17 at 73,351,508 bp
  • T to C, chromosome 17 at 79,628,286 bp
  • T to A, chromosome 18 at 53,197,889 bp
  • A to G, chromosome 18 at 61,517,993 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0746 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038927-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.