Strain Name:
C57BL/6J-MtgxR0784Btlr/Mmmh
Stock Number:
038964-MU
Citation ID:
RRID:MMRRC_038964-MU
Other Names:
R0784 (G1), C57BL/6J-MtgxR0784Btlr
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, Myhn1, NMHC II-A, Fltn, Myhn-1, myosin IIA, E030044M24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66743
Homologene: 10036
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Atf6
Name: activating transcription factor 6
Synonyms: Atf6alpha, ESTM49, 9130025P16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226641
HGNC: HGNC:791
Homologene: 32015
Drosha
Name: drosha, ribonuclease type III
Synonyms: 1110013A17Rik, Etohi2, Rnasen
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: Ltpr7, 2310022G15Rik, LTRPC7, 5033407O22Rik, TRP-PLIK, CHAK, CHAK1, 4833414K03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12808
Homologene: 9058
Dennd4c
Name: DENN domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329877
Homologene: 23057
Bicd1
Name: BICD cargo adaptor 1
Synonyms: B830009D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12121
HGNC: HGNC:1049
Homologene: 37518
Senp3
Name: SUMO/sentrin specific peptidase 3
Synonyms: Smt3ip1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 80886
Homologene: 9236
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229681
Homologene: 14910
Smtnl2
Name: smoothelin-like 2
Synonyms: D130058I21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276829
Homologene: 82367
Acin1
Name: apoptotic chromatin condensation inducer 1
Synonyms: 2610036I19Rik, Acinus, 2610510L13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56215
Homologene: 22853
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
LTO1
Name: ABCE maturation factor
Synonyms: TAOS1, Oraov1, 2210010N10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72284
Homologene: 12457
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2610101O16Rik, cat eye syndrome chromosome region, candidate 2, 2810409N01Rik, Gtl4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Dync1li2
Name: dynein, cytoplasmic 1 light intermediate chain 2
Synonyms: LIC2, Dlic2, Dncli2, Dnclic2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234663
HGNC: HGNC:2966
Homologene: 4474
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: Hnrpul2, 1110031M08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74044
Homologene: 37826
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56220
Homologene: 51668
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Grn
Name: granulin
Synonyms: epithelin, acrogranulin, PC cell-derived growth factor, Pgrn, progranulin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14824
HGNC: HGNC:4601
Homologene: 1577
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: Gcn5, Gcn5l2, 1110051E14Rik, PCAF-B/GCN5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Hoxa13
Name: homeobox A13
Synonyms: Hox-1.10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15398
HGNC: HGNC:5102
Homologene: 73882
Clcn3
Name: chloride channel, voltage-sensitive 3
Synonyms: Clc3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12725
HGNC: HGNC:2021
Homologene: 20435
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC5/6A, PC6, b2b1549Clo, SPC6, PC5A, b2b585Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: Svs1, SVS I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243377
HGNC: HGNC:80
Homologene: 18250
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: E430002F06Rik, A430075I06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231050
Homologene: 11126
Akna
Name: AT-hook transcription factor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100182
Homologene: 49947
Stk35
Name: serine/threonine kinase 35
Synonyms: CLP-36 interacting kinase, 1700054C12Rik, CLIK1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67333
Homologene: 15441
Adamts2
Name: ADAM metallopeptidase with thrombospondin type 1 motif 2
Synonyms: hPCPNI, a disintegrin and metalloproteinase with thrombospondin repeats, procollagen N-proteinase, ADAM-TS2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Fam38b
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
St8sia3
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Synonyms: Siat8c, ST8SiaIII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20451
Homologene: 8285
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666528
Homologene: 12991
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, nmMlck, Mlck, 9530072E15Rik, MLCK108, MLCK210, A930019C19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Slc6a15
Name: solute carrier family 6 (neurotransmitter transporter), member 15
Synonyms: v7-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103098
VEGA: 10
Homologene: 18163
Cyba
Name: cytochrome b-245, alpha polypeptide
Synonyms: cytochrome beta-558, p22 phox, b558
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13057
HGNC: HGNC:2577
Homologene: 80
Shc4
Name: SHC (Src homology 2 domain containing) family, member 4
Synonyms: 9930029B02Rik, LOC271849, 6230417E10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271849
Homologene: 19567
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: D130067I03Rik, 1700074E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Or4ac1-ps1
Name: olfactory receptor family 4 subfamily AC member 1, pseudogene 1
Synonyms: Olfr1187-ps1, GA_x6K02T2Q125-50027818-50027495
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404484
VEGA: 2
Cbfa2t3
Name: CBFA2/RUNX1 translocation partner 3
Synonyms: ETO-2, Eto2, A630044F12Rik, MTGR2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12398
HGNC: HGNC:1537
Homologene: 74543
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: TPO-R, hlb219, thrombopoietin receptor, c-mpl, c-mpl-II, c-mpl-I, CD110
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
Cd46
Name: CD46 antigen, complement regulatory protein
Synonyms: CD46, Mcp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17221
HGNC: HGNC:6953
Homologene: 7832
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 21674
Gpr176
Name: G protein-coupled receptor 176
Synonyms: LOC381413
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381413
Homologene: 5226
Klhl29
Name: kelch-like 29
Synonyms: Kbtbd9, A230106N14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
Mtnr1b
Name: melatonin receptor 1B
Synonyms: Mel1b, Mt2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244701
HGNC: HGNC:7464
Homologene: 4350
Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
Synonyms: IAP, Akp-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11648
Homologene: 134333
Prr36
Name: proline rich 36
Synonyms: BC068157
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73072
Homologene: 136398
Or2z2
Name: olfactory receptor family 2 subfamily Z member 2
Synonyms: Olfr30, MOR281-1, MTPCR07, GA_x6K02T2NKPP-957001-957948
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18329
Homologene: 131139
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54667
Homologene: 23226
Ahr
Name: aryl-hydrocarbon receptor
Synonyms: bHLHe76, dioxin receptor, Ahre, Ahh, Ah, In
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11622
HGNC: HGNC:348
Homologene: 1224
Asic2
Name: acid-sensing ion channel 2
Synonyms: BNaC1a, Mdeg, Accn1, BNC1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11418
HGNC: HGNC:99
Homologene: 137202
Tmem106b
Name: transmembrane protein 106B
Synonyms: 6430519M21Rik, 5830455K21Rik, 2310036D22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71900
Homologene: 56806
Gpr85
Name: G protein-coupled receptor 85
Synonyms: 2900026B03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64450
HGNC: HGNC:4536
Homologene: 10355
Irx5
Name: Iroquois homeobox 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54352
Homologene: 38105
AC156643.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 87,127,871 bp
  • T to C, chromosome 1 at 129,595,359 bp
  • A to G, chromosome 1 at 170,709,947 bp
  • G to A, chromosome 1 at 195,092,194 bp
  • A to G, chromosome 2 at 38,021,414 bp
  • A to G, chromosome 2 at 69,518,365 bp
  • T to A, chromosome 2 at 88,540,167 bp
  • C to T, chromosome 2 at 118,373,052 bp
  • A to C, chromosome 2 at 125,657,496 bp
  • A to G, chromosome 2 at 126,846,072 bp
  • A to T, chromosome 2 at 129,810,802 bp
  • A to T, chromosome 3 at 89,957,073 bp
  • T to C, chromosome 3 at 100,962,710 bp
  • A to G, chromosome 3 at 104,870,924 bp
  • G to T, chromosome 4 at 63,376,888 bp
  • A to T, chromosome 4 at 86,844,908 bp
  • C to A, chromosome 4 at 117,277,998 bp
  • G to A, chromosome 4 at 118,446,406 bp
  • A to G, chromosome 5 at 25,258,909 bp
  • A to T, chromosome 5 at 25,310,895 bp
  • T to C, chromosome 6 at 13,084,253 bp
  • T to A, chromosome 6 at 13,836,749 bp
  • T to A, chromosome 6 at 48,987,301 bp
  • G to C, chromosome 6 at 52,259,937 bp
  • A to G, chromosome 6 at 120,758,149 bp
  • T to A, chromosome 6 at 149,513,363 bp
  • A to G, chromosome 7 at 16,082,992 bp
  • A to T, chromosome 7 at 144,919,277 bp
  • G to T, chromosome 8 at 4,213,771 bp
  • G to T, chromosome 8 at 60,929,203 bp
  • A to G, chromosome 8 at 92,360,490 bp
  • A to G, chromosome 8 at 104,442,498 bp
  • T to A, chromosome 8 at 122,427,683 bp
  • A to G, chromosome 8 at 122,650,487 bp
  • A to G, chromosome 9 at 15,862,785 bp
  • A to G, chromosome 9 at 59,896,545 bp
  • A to G, chromosome 10 at 103,416,800 bp
  • T to G, chromosome 11 at 12,266,843 bp
  • C to T, chromosome 11 at 50,668,003 bp
  • T to A, chromosome 11 at 58,455,305 bp
  • A to G, chromosome 11 at 69,680,448 bp
  • T to C, chromosome 11 at 72,399,937 bp
  • T to A, chromosome 11 at 80,893,989 bp
  • C to T, chromosome 11 at 100,710,841 bp
  • T to C, chromosome 11 at 102,434,502 bp
  • T to C, chromosome 12 at 5,081,251 bp
  • C to T, chromosome 12 at 35,508,142 bp
  • T to A, chromosome 12 at 82,496,180 bp
  • T to A, chromosome 12 at 116,059,920 bp
  • T to C, chromosome 14 at 54,653,528 bp
  • T to C, chromosome 15 at 12,867,678 bp
  • A to G, chromosome 15 at 77,777,009 bp
  • G to C, chromosome 16 at 34,879,475 bp
  • T to A, chromosome 17 at 71,275,287 bp
  • T to A, chromosome 18 at 63,083,235 bp
  • T to C, chromosome 18 at 64,271,701 bp
  • T to C, chromosome 19 at 8,825,052 bp
  • T to C, chromosome 19 at 17,714,769 bp
  • G to T, chromosome Y at 2,662,731 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0784 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038964-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.