Strain Name:
C57BL/6J-MtgxR0785Btlr/Mmmh
Stock Number:
038965-MU
Citation ID:
RRID:MMRRC_038965-MU
Other Names:
R0785 (G1), C57BL/6J-MtgxR0785Btlr
Major Collection:

Strain Information

Fkbp11
Name: FK506 binding protein 11
Synonyms: 1110002O23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66120
VEGA: 15
Homologene: 9581
Mtmr14
Name: myotubularin related protein 14
Synonyms: 1110061O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 97287
Homologene: 11203
Rps6kc1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: RPK118, B130003F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320119
Homologene: 8244
9030025P20Rik
Name: RIKEN cDNA 9030025P20 gene
Synonyms: D17Zt9e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100041574
VEGA: 17
Homologene: 104886
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78286
Homologene: 52330
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 2810429C13Rik, 1110031N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235559
Homologene: 38262
Eif2b2
Name: eukaryotic translation initiation factor 2B, subunit 2 beta
Synonyms: EIF-2Bbeta, EIF2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217715
HGNC: HGNC:3258
Homologene: 6507
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Ern2
Name: endoplasmic reticulum (ER) to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26918
Homologene: 22687
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329650
Homologene: 43143
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: Myak, 1110062K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15257
Homologene: 56483
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Golgb1
Name: golgi autoantigen, golgin subfamily b, macrogolgin 1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Pld5
Name: phospholipase D family, member 5
Synonyms: B230365F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319455
Homologene: 16081
Abca14
Name: ATP-binding cassette, sub-family A (ABC1), member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67928
Homologene: 86128
Adam10
Name: a disintegrin and metallopeptidase domain 10
Synonyms: kuz, kuzbanian, 1700031C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11487
HGNC: HGNC:188
Homologene: 865
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Krt2
Name: keratin 2
Synonyms: Krt2-2, Krt2e, Krt2-17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16681
HGNC: HGNC:6439
Myorg
Name: myogenesis regulating glycosidase (putative)
Synonyms: NET37, AI464131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329828
Homologene: 19853
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 260305
Homologene: 9024
Trappc1
Name: trafficking protein particle complex 1
Synonyms: MUM2, BET5, D11Ertd172e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245828
Homologene: 41425
Tmem243
Name: transmembrane protein 243, mitochondrial
Synonyms: E030031F02Rik, 4930420K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 652925
Homologene: 41561
CAAA01123846.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Polr1g
Name: RNA polymerase I subunit G
Synonyms: PAF49, 2610103M17Rik, Ase1, Cd3eap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70333
Homologene: 17107
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: mt2r52, Tas2r36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353165
Homologene: 136304
Adh6a
Name: alcohol dehydrogenase 6A (class V)
Synonyms: Adh5a, 1810009C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69117
Homologene: 66291
Ccdc121rt2
Name: coiled-coil domain containing 121, retrogene 2
Synonyms: Gm6588
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 625464
Homologene: 116059
Or6c75
Name: olfactory receptor family 6 subfamily C member 75
Synonyms: GA_x6K02T2PULF-11179777-11180721, MOR112-1, Olfr790
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258935
Homologene: 74101
Or2b7
Name: olfactory receptor family 2 subfamily B member 7
Synonyms: MOR256-36, GA_x6K02T2QHY8-11688984-11689964, MOR256-63, MOR256-36, Olfr1365, Olfr1535
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 404335
Homologene: 131356
Zfp300
Name: zinc finger protein 300
Synonyms: D930016N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245368
Homologene: 65054
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 175,975,452 bp
  • A to G, chromosome 1 at 190,808,945 bp
  • A to G, chromosome 2 at 79,289,305 bp
  • T to C, chromosome 3 at 36,959,334 bp
  • T to A, chromosome 3 at 59,260,832 bp
  • G to T, chromosome 3 at 103,754,325 bp
  • T to C, chromosome 3 at 138,329,068 bp
  • A to G, chromosome 4 at 41,497,539 bp
  • A to G, chromosome 4 at 152,562,109 bp
  • C to A, chromosome 4 at 156,351,101 bp
  • A to T, chromosome 5 at 9,118,488 bp
  • A to T, chromosome 5 at 41,820,016 bp
  • A to G, chromosome 5 at 112,450,568 bp
  • T to C, chromosome 6 at 113,277,947 bp
  • T to C, chromosome 6 at 132,777,927 bp
  • G to C, chromosome 7 at 19,357,285 bp
  • T to A, chromosome 7 at 49,420,333 bp
  • G to A, chromosome 7 at 120,294,157 bp
  • A to T, chromosome 7 at 122,171,661 bp
  • A to G, chromosome 9 at 70,767,888 bp
  • A to G, chromosome 9 at 103,315,090 bp
  • A to G, chromosome 10 at 129,500,881 bp
  • A to G, chromosome 11 at 69,324,810 bp
  • T to A, chromosome 12 at 52,886,622 bp
  • C to A, chromosome 12 at 85,221,561 bp
  • A to G, chromosome 13 at 21,555,788 bp
  • A to G, chromosome 13 at 100,423,076 bp
  • C to T, chromosome 13 at 100,423,085 bp
  • T to C, chromosome 15 at 98,726,549 bp
  • C to A, chromosome 15 at 101,817,921 bp
  • A to G, chromosome 16 at 36,898,790 bp
  • T to A, chromosome 17 at 15,021,977 bp
  • A to C, chromosome 19 at 38,133,180 bp
  • T to C, chromosome X at 21,082,925 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0785 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038965-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.