Strain Name:
C57BL/6J-MtgxR0815Btlr/Mmmh
Stock Number:
038995-MU
Citation ID:
RRID:MMRRC_038995-MU
Other Names:
R0815 (G1), C57BL/6J-MtgxR0815Btlr
Major Collection:

Gene Information

Tnf
Name: tumor necrosis factor
Synonyms: TNF-alpha, tumor necrosis factor-alpha, TNF alpha, TNFalpha, DIF, Tnfsf1a, Tnfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21926
Homologene: 496
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, 9530097L16Rik, D5Wsu150e, SERCA2B, Serca2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Fbxo21
Name: F-box protein 21
Synonyms: 2810425J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231670
Homologene: 14145
Slc44a1
Name: solute carrier family 44, member 1
Synonyms: CHTL1, CTL1, 4833416H08Rik, Cdw92, 2210409B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100434
Homologene: 11137
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730455C01Rik, 9130215G10Rik, 5730555F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 4930596K11Rik, 6330407G04Rik, CHMP family, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105513
VEGA: 14
Homologene: 14613
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20658
Homologene: 10551
Slc39a4
Name: solute carrier family 39 (zinc transporter), member 4
Synonyms: zip4, 1600025H15Rik, AWMS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72027
VEGA: 15
Homologene: 15638
Oga
Name: O-GlcNAcase
Synonyms: Hy5, 5830447M11Rik, 4833427O07Rik, 2810009A20Rik, Mgea5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76055
VEGA: 19
HGNC: HGNC:7056
Homologene: 8154
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Robo3
Name: roundabout guidance receptor 3
Synonyms: Rig-1, Rbig1, Robo3b, Robo3a, Rig1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19649
Homologene: 32119
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238988
Homologene: 69188
Abcf2
Name: ATP-binding cassette, sub-family F (GCN20), member 2
Synonyms: 0710005O05Rik, Drr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27407
HGNC: HGNC:71
Homologene: 21408
Frmd8
Name: FERM domain containing 8
Synonyms: 4931429L16Rik, 2310035N23Rik, 1200004M23Rik, iTAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67457
Homologene: 32653
Ppp1r12c
Name: protein phosphatase 1, regulatory subunit 12C
Synonyms: 2410197A17Rik, Mbs85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232807
Homologene: 75071
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229473
Homologene: 9057
Lrrc8c
Name: leucine rich repeat containing 8 family, member C
Synonyms: E430036I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100604
Homologene: 12997
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20850
Homologene: 20680
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Sec31b
Name: Sec31 homolog B (S. cerevisiae)
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240667
Homologene: 56708
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: mfmi1, flamingo, EGFL2, Adgrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Lipm
Name: lipase, family member M
Synonyms: 4632427C23Rik, Lipl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 78753
VEGA: 19
Homologene: 28267
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117600
Homologene: 56898
Rbm11
Name: RNA binding motif protein 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224344
HGNC: HGNC:9897
Homologene: 16988
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381852
Homologene: 115938
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217328
Dpp10
Name: dipeptidylpeptidase 10
Synonyms: DPRP3, 6430601K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269109
Homologene: 41400
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665227
Homologene: 129751
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22625
Homologene: 19318
Sp140
Name: Sp140 nuclear body protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 434484
Homologene: 128391
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Rsbn1
Name: rosbin, round spermatid basic protein 1
Synonyms: Rsbp, C230004D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229675
Homologene: 10154
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: F830032C23Rik, Card15, Nlrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Olfr1444
Name: olfactory receptor 1444
Synonyms: GA_x6K02T2RE5P-3191201-3192160, MOR202-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258697
Homologene: 64906
Parva
Name: parvin, alpha
Synonyms: CH-ILKBP, 5430400F08Rik, 2010012A22Rik, actopaxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57342
Homologene: 10077
Scel
Name: sciellin
Synonyms: 9230114I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 64929
VEGA: 14
Homologene: 2850
Thnsl2
Name: threonine synthase-like 2 (bacterial)
Synonyms: TSH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232078
Homologene: 5489
Gfm1
Name: G elongation factor, mitochondrial 1
Synonyms: D3Wsu133e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 28030
Homologene: 6449
Slc38a11
Name: solute carrier family 38, member 11
Synonyms: 9330158F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320106
Homologene: 5775
Olfr319
Name: olfactory receptor 319
Synonyms: GA_x6K02T2NKPP-708319-707399, MOR285-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258493
H2-Ab1
Name: histocompatibility 2, class II antigen A, beta 1
Synonyms: A beta, Abeta, H-2Ab, Ia-2, Ia2, H2-Ab, IAb, I-Ab, I-Abeta, Rmcs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14961
HGNC: HGNC:4944
Homologene: 1603
Phf1
Name: PHD finger protein 1
Synonyms: Tctex-3, D17Ertd455e, PHF2, Tctex3, mPcl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21652
VEGA: 17
HGNC: HGNC:8919
Homologene: 7567
Teddm1b
Name: transmembrane epididymal protein 1B
Synonyms: Gm5531
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433365
Homologene: 131186
Supt4a
Name: SPT4A, DSIF elongation factor subunit
Synonyms: Supt4h, Supt4h1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20922
Homologene: 68303
Med31
Name: mediator complex subunit 31
Synonyms: 3110004H13Rik, l11Jus15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67279
Homologene: 9368
Upp2
Name: uridine phosphorylase 2
Synonyms: UDRPASE2, UPASE2, UP2, 1700124F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76654
Homologene: 12654
1700057G04Rik
Name: RIKEN cDNA 1700057G04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78459
Homologene: 134508
Nemp1
Name: nuclear envelope integral membrane protein 1
Synonyms: Tmem194
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210035
Homologene: 18346
Tinf2
Name: Terf1 (TRF1)-interacting nuclear factor 2
Synonyms: TIN2, D14Wsu146e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 28113
VEGA: 14
Homologene: 8264
H2-M10.3
Name: histocompatibility 2, M region locus 10.3
Synonyms: 5.3H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 110696
Homologene: 117973
Eif3j2
Name: eukaryotic translation initiation factor 3, subunit J2
Synonyms: Gm9781
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100042807
HGNC: HGNC:3270
Homologene: 37845
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 75,415,392 bp
  • C to T, chromosome 1 at 85,620,051 bp
  • A to G, chromosome 1 at 123,432,929 bp
  • A to G, chromosome 1 at 127,834,638 bp
  • A to T, chromosome 1 at 136,112,957 bp
  • A to G, chromosome 1 at 153,874,892 bp
  • A to G, chromosome 2 at 58,771,556 bp
  • T to A, chromosome 2 at 65,353,780 bp
  • T to A, chromosome 3 at 5,245,315 bp
  • T to C, chromosome 3 at 67,474,595 bp
  • A to G, chromosome 3 at 83,940,572 bp
  • T to G, chromosome 3 at 103,954,153 bp
  • G to T, chromosome 3 at 108,401,301 bp
  • T to G, chromosome 4 at 53,536,421 bp
  • A to T, chromosome 5 at 24,567,270 bp
  • T to C, chromosome 5 at 105,608,534 bp
  • T to C, chromosome 5 at 117,995,508 bp
  • T to C, chromosome 5 at 122,471,236 bp
  • A to T, chromosome 6 at 71,134,224 bp
  • G to T, chromosome 7 at 4,486,366 bp
  • A to T, chromosome 7 at 17,902,742 bp
  • G to A, chromosome 7 at 112,567,864 bp
  • G to A, chromosome 8 at 88,672,662 bp
  • A to G, chromosome 9 at 37,422,183 bp
  • A to G, chromosome 9 at 45,745,074 bp
  • A to G, chromosome 9 at 70,561,908 bp
  • A to T, chromosome 9 at 92,351,087 bp
  • A to T, chromosome 10 at 121,785,474 bp
  • T to C, chromosome 10 at 127,693,024 bp
  • A to G, chromosome 11 at 58,702,609 bp
  • T to A, chromosome 11 at 72,213,831 bp
  • T to A, chromosome 11 at 87,737,583 bp
  • A to G, chromosome 11 at 100,875,082 bp
  • T to G, chromosome 11 at 115,866,336 bp
  • A to T, chromosome 12 at 55,762,681 bp
  • C to A, chromosome 12 at 55,782,777 bp
  • A to G, chromosome 12 at 118,901,449 bp
  • A to C, chromosome 14 at 28,025,148 bp
  • T to A, chromosome 14 at 31,369,757 bp
  • G to A, chromosome 14 at 55,680,109 bp
  • T to C, chromosome 14 at 55,783,599 bp
  • T to C, chromosome 14 at 62,419,062 bp
  • C to T, chromosome 14 at 69,719,450 bp
  • T to A, chromosome 14 at 103,586,480 bp
  • C to T, chromosome 15 at 76,612,639 bp
  • C to T, chromosome 16 at 75,596,637 bp
  • C to A, chromosome 16 at 91,655,484 bp
  • T to G, chromosome 17 at 18,257,711 bp
  • T to C, chromosome 17 at 26,937,140 bp
  • T to C, chromosome 17 at 34,267,354 bp
  • T to C, chromosome 17 at 35,201,144 bp
  • T to A, chromosome 17 at 36,366,690 bp
  • T to C, chromosome 17 at 46,537,822 bp
  • T to A, chromosome 18 at 43,476,971 bp
  • A to T, chromosome 19 at 5,865,056 bp
  • A to G, chromosome 19 at 12,862,644 bp
  • A to T, chromosome 19 at 34,118,761 bp
  • G to A, chromosome 19 at 44,518,173 bp
  • C to T, chromosome 19 at 45,782,986 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0815 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038995-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.