Strain Name:
C57BL/6J-MtgxR0837Btlr/Mmmh
Stock Number:
039016-MU
Citation ID:
RRID:MMRRC_039016-MU
Other Names:
R0837 (G1), C57BL/6J-MtgxR0837Btlr
Major Collection:

Gene Information

Prnp
Name: prion protein
Synonyms: PrPSc, CD230, PrPC, Prn-p, Sinc, PrP, Prn-i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19122
HGNC: HGNC:9449
Homologene: 7904
Rtn4rl2
Name: reticulon 4 receptor-like 2
Synonyms: Ngrl3, Ngr2, Ngrh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269295
Homologene: 18683
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74315
Homologene: 14427
Usp7
Name: ubiquitin specific peptidase 7
Synonyms: 2210010O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 252870
Homologene: 2592
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: D10Ertd398e, 4.1G, Epb4.1l2, NBL2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: steroid-11-beta-hydroxylase, Cyp11b-2, aldosterone synthase, Cyp11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 13072
Homologene: 128035
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22241
Homologene: 2640
Trappc12
Name: trafficking protein particle complex 12
Synonyms: CGI-87, D930014A20Rik, Ttc15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217449
VEGA: 12
Homologene: 34805
Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Synonyms: Syp, Shp2, SHP-2, SH-PTP2, PTP1D, PTP2C, SH2 domain-containing protein tyrosine phosphatase-2, 2700084A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19247
HGNC: HGNC:9644
Homologene: 2122
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: Zfp291, D530014O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244891
VEGA: 9
Homologene: 32488
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: gamma-adaptin, D8Ertd374e, Adtg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: 2700017A04Rik, Ankrd32, Brctd1, C730024G01Rik, Brctx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105377
Homologene: 13000
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Dock7
Name: dedicator of cytokinesis 7
Synonyms: m, 3110056M06Rik, LOC242555
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67299
Homologene: 23566
Cpsf2
Name: cleavage and polyadenylation specific factor 2
Synonyms: Cpsf, 100kDa, 2610024B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 51786
VEGA: 12
HGNC: HGNC:2325
Homologene: 6460
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Doc4, ELM2, l7Rn3, Odz4, Ten-m4, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 23966
Homologene: 8034
Zfy1
Name: zinc finger protein 1, Y-linked
Synonyms: Zfy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 22767
Homologene: 56456
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: 4432416O06Rik, DHC2, b2b414Clo, Dnchc2, m407Asp, m152Asp, D030010H02Rik, D330044F14Rik, DHC1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Rab40c
Name: Rab40C, member RAS oncogene family
Synonyms: RAR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224624
Homologene: 10907
Sema4a
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Synonyms: Semab, SemB, SemB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20351
Homologene: 8425
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Bicdl1
Name: BICD family like cargo adaptor 1
Synonyms: BICDR-1, Ccdc64, 2210403N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75665
Homologene: 18013
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, L-type Cav1.2, Cav1.2, Cchl1a1, D930026N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Tnfaip2
Name: tumor necrosis factor, alpha-induced protein 2
Synonyms: Tnfip2, Exoc3l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 21928
Homologene: 4583
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Birc1e, Naip-rs3, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627636
Homologene: 115024
Unc80
Name: unc-80, NALCN activator
Synonyms: C030018G13Rik, C230061B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329178
Homologene: 122243
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: LaXp180, 2900055E04Rik, 5930404L04Rik, Fip200, Cc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12421
Homologene: 7659
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241514
Homologene: 18461
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20957
Homologene: 2389
Kcnq4
Name: potassium voltage-gated channel, subfamily Q, member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 60613
HGNC: HGNC:6298
Homologene: 78107
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 252866
Homologene: 78104
4930563I02Rik
Name: RIKEN cDNA 4930563I02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67659
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100559
Homologene: 137225
Mto1
Name: mitochondrial tRNA translation optimization 1
Synonyms: 5730419A02Rik, 2310039H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68291
Homologene: 5876
Mthfs
Name: 5, 10-methenyltetrahydrofolate synthetase
Synonyms: 1110034I12Rik, 2310020H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 107885
Homologene: 4702
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 665255
Homologene: 129605
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 2010013I23Rik, 9130206N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 103406
Homologene: 88124
4930579C12Rik
Name: RIKEN cDNA 4930579C12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319213
Prl7d1
Name: prolactin family 7, subfamily d, member 1
Synonyms: Plfr, PRP, PLF-RP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18814
Homologene: 7894
Olfr433
Name: olfactory receptor 433
Synonyms: MOR123-1, GA_x6K02T2P20D-21133014-21132070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 258712
Homologene: 133588
Hist2h2ab
Name: histone cluster 2, H2ab
Synonyms: EG621893, H2a-613a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 621893
Homologene: 111318
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,234,271 bp
  • G to A, chromosome 1 at 66,648,944 bp
  • A to G, chromosome 1 at 174,042,487 bp
  • A to C, chromosome 2 at 82,259,162 bp
  • T to C, chromosome 2 at 84,880,692 bp
  • A to T, chromosome 2 at 131,936,524 bp
  • T to A, chromosome 3 at 88,453,098 bp
  • G to A, chromosome 3 at 96,220,123 bp
  • G to T, chromosome 3 at 102,915,245 bp
  • C to T, chromosome 4 at 98,989,258 bp
  • T to A, chromosome 4 at 120,746,861 bp
  • G to A, chromosome 5 at 87,411,773 bp
  • A to T, chromosome 5 at 110,789,545 bp
  • G to A, chromosome 5 at 115,731,292 bp
  • C to T, chromosome 5 at 121,149,111 bp
  • A to T, chromosome 6 at 118,630,270 bp
  • G to A, chromosome 6 at 136,722,420 bp
  • G to A, chromosome 6 at 139,957,699 bp
  • T to A, chromosome 7 at 5,488,027 bp
  • T to C, chromosome 7 at 96,896,275 bp
  • T to A, chromosome 8 at 43,651,500 bp
  • A to G, chromosome 8 at 85,096,829 bp
  • T to C, chromosome 8 at 109,851,065 bp
  • C to A, chromosome 9 at 7,077,979 bp
  • A to T, chromosome 9 at 55,859,042 bp
  • A to T, chromosome 9 at 78,473,790 bp
  • A to G, chromosome 9 at 89,168,207 bp
  • A to G, chromosome 9 at 89,215,390 bp
  • C to T, chromosome 10 at 25,507,816 bp
  • A to G, chromosome 10 at 81,245,408 bp
  • T to C, chromosome 11 at 44,524,988 bp
  • A to G, chromosome 11 at 60,487,251 bp
  • A to G, chromosome 12 at 28,703,597 bp
  • C to T, chromosome 12 at 101,997,242 bp
  • A to G, chromosome 12 at 111,450,707 bp
  • T to A, chromosome 13 at 27,714,338 bp
  • T to C, chromosome 13 at 77,100,948 bp
  • T to A, chromosome 13 at 100,230,743 bp
  • T to C, chromosome 14 at 60,095,926 bp
  • G to A, chromosome 15 at 74,853,641 bp
  • C to A, chromosome 16 at 8,703,502 bp
  • A to G, chromosome 17 at 19,793,927 bp
  • G to A, chromosome 17 at 25,884,693 bp
  • A to T, chromosome Y at 725,850 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0837 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039016-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.