Strain Name:
C57BL/6J-MtgxR0864Btlr/Mmmh
Stock Number:
039038-MU
Citation ID:
RRID:MMRRC_039038-MU
Other Names:
R0864 (G1), C57BL/6J-MtgxR0864Btlr
Major Collection:

Strain Information

Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Mapk8
Name: mitogen-activated protein kinase 8
Synonyms: JNK1, c-Jun N-terminal kinase, Prkm8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 26419
HGNC: HGNC:6881
Homologene: 56760
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, Alpha-MPP, 4933435E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66865
Homologene: 6078
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Ctnnbl1
Name: catenin, beta like 1
Synonyms: NYD-SP19, FLJ21108, P14L, 5730471K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66642
Homologene: 12003
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Bwq1, Kiaa1064-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330474
Homologene: 87150
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Ywhae
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Synonyms: 14-3-3 epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22627
Homologene: 100743
Rbbp4
Name: retinoblastoma binding protein 4, chromatin remodeling factor
Synonyms: CAF-1 p48 subunit, RBAP48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19646
HGNC: HGNC:9887
Homologene: 21153
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14897
Homologene: 44226
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: Alix, AIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Alx4
Name: aristaless-like homeobox 4
Synonyms: Aristaless-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11695
HGNC: HGNC:450
Homologene: 7229
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Clmn
Name: calmin
Synonyms: 9330188N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94040
VEGA: 12
Homologene: 11683
Zfp280b
Name: zinc finger protein 280B
Synonyms: D10Jhu82e, Suhw2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64453
VEGA: 10
Homologene: 62794
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241589
Homologene: 115928
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: RIP3, p116Rip, p116 Rho interacting protein, Rhoip3, Gm34094
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26936
Homologene: 9034
Trim43a
Name: tripartite motif-containing 43A
Synonyms: Gm6021
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 547109
Homologene: 105432
Pdk2
Name: pyruvate dehydrogenase kinase, isoenzyme 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18604
HGNC: HGNC:8810
Homologene: 68265
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244962
Homologene: 17823
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57435
Homologene: 69311
Chac1
Name: ChaC, cation transport regulator 1
Synonyms: 1810008K03Rik, Botch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69065
Homologene: 11470
Hpn
Name: hepsin
Synonyms: Hlb320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15451
HGNC: HGNC:5155
Homologene: 20498
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Iqca
Name: IQ motif containing with AAA domain
Synonyms: 4930585L22Rik, 4930465P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74918
Homologene: 49784
Supt4a
Name: SPT4A, DSIF elongation factor subunit
Synonyms: Supt4h, Supt4h1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20922
Homologene: 68303
Dyrk4
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Synonyms: Dyrk4b, Dyrk4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101320
HGNC: HGNC:3095
Homologene: 37858
Vmn1r36
Name: vomeronasal 1 receptor 36
Synonyms: V1rc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171184
Homologene: 110800
Rbms3
Name: RNA binding motif, single stranded interacting protein
Synonyms: 6720477E09Rik, 8430436O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 207181
Homologene: 49388
Gapt
Name: Grb2-binding adaptor, transmembrane
Synonyms: 9830130M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238875
VEGA: 13
Homologene: 51887
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666348
VEGA: 15
Homologene: 40940
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 84,744,009 bp
  • C to A, chromosome 1 at 90,142,731 bp
  • G to A, chromosome 2 at 26,393,209 bp
  • A to G, chromosome 2 at 48,894,786 bp
  • A to G, chromosome 2 at 93,642,855 bp
  • G to A, chromosome 2 at 104,230,428 bp
  • C to A, chromosome 2 at 119,353,469 bp
  • A to T, chromosome 2 at 125,342,891 bp
  • C to T, chromosome 2 at 157,799,417 bp
  • G to T, chromosome 4 at 56,890,837 bp
  • G to T, chromosome 4 at 129,320,551 bp
  • T to C, chromosome 6 at 66,716,856 bp
  • T to C, chromosome 6 at 126,877,333 bp
  • T to A, chromosome 7 at 16,420,179 bp
  • T to C, chromosome 7 at 31,109,001 bp
  • T to A, chromosome 8 at 16,190,026 bp
  • T to A, chromosome 8 at 45,018,037 bp
  • A to T, chromosome 9 at 88,383,996 bp
  • A to T, chromosome 9 at 88,843,034 bp
  • A to G, chromosome 9 at 109,978,969 bp
  • G to A, chromosome 9 at 110,628,195 bp
  • A to T, chromosome 9 at 113,674,510 bp
  • A to T, chromosome 9 at 117,629,792 bp
  • C to T, chromosome 10 at 76,038,305 bp
  • T to C, chromosome 11 at 59,758,761 bp
  • T to G, chromosome 11 at 75,759,430 bp
  • T to A, chromosome 11 at 87,743,087 bp
  • A to G, chromosome 11 at 95,027,933 bp
  • G to A, chromosome 12 at 104,790,015 bp
  • G to C, chromosome 13 at 110,353,739 bp
  • C to T, chromosome 14 at 33,392,992 bp
  • T to C, chromosome 14 at 70,395,374 bp
  • T to A, chromosome 15 at 77,717,793 bp
  • A to G, chromosome 16 at 32,752,002 bp
  • T to A, chromosome 17 at 56,103,966 bp
  • A to G, chromosome 17 at 87,680,052 bp
  • G to A, chromosome 18 at 11,732,184 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0864 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039038-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.