Strain Name:
C57BL/6J-MtgxR0905Btlr/Mmmh
Stock Number:
039063-MU
Citation ID:
RRID:MMRRC_039063-MU
Other Names:
R0905 (G1), C57BL/6J-MtgxR0905Btlr
Major Collection:

Gene Information

Phf12
Name: PHD finger protein 12
Synonyms: 2410142K10Rik, PF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268448
Homologene: 10841
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: 53BP1, p53BP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27223
Homologene: 4137
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: ARHGAP10, 5530401C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71435
Homologene: 10822
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 328329
Homologene: 42094
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, 2610202A04Rik, D16Ium21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 22129
Homologene: 2487
Impdh2
Name: inosine monophosphate dehydrogenase 2
Synonyms: IMP dehydrogenase type II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 23918
HGNC: HGNC:6053
Homologene: 48919
Hsd17b11
Name: hydroxysteroid (17-beta) dehydrogenase 11
Synonyms: Dhrs8, 17beta-HSD11, Pan1b, retSDR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 114664
Homologene: 69209
Il31ra
Name: interleukin 31 receptor A
Synonyms: GLM-R, GPL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218624
VEGA: 13
Homologene: 51395
Itih5
Name: inter-alpha (globulin) inhibitor H5
Synonyms: 4631408O11Rik, 5430408M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 209378
Homologene: 57115
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329252
Homologene: 49680
Crtc1
Name: CREB regulated transcription coactivator 1
Synonyms: TORC1, Mect1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382056
Homologene: 41607
Bsph1
Name: binder of sperm protein homolog 1
Synonyms: LOC330470
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330470
Homologene: 86818
Epb41l4b
Name: erythrocyte membrane protein band 4.1 like 4b
Synonyms: Lulu2, 6430543G08Rik, Epb4.1l4b, Ehm2, D4Ertd346e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54357
Homologene: 69270
Prdm14
Name: PR domain containing 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 383491
Homologene: 11556
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 544678
Homologene: 129584
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 21683
Homologene: 3955
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 319555
Homologene: 72261
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: Liprin-alpha2, E130120L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Lgsn
Name: lengsin, lens protein with glutamine synthetase domain
Synonyms: Gluld1, lengsin, Lgs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 266744
Homologene: 9569
Dbn1
Name: drebrin 1
Synonyms: drebrin A, drebrin E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56320
HGNC: HGNC:2695
Homologene: 3236
Spn
Name: sialophorin
Synonyms: leukosialin, Cd43, Ly48, Galgp, 3E8 antigen, Ly-48, A630014B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20737
Homologene: 36108
Hltf
Name: helicase-like transcription factor
Synonyms: Snf2l3, P113, Smarca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20585
Homologene: 30136
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: Semag, SemG, SemG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 20357
Homologene: 8427
Cspg5
Name: chondroitin sulfate proteoglycan 5
Synonyms: NGC, neuroglycan C, CALEB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 29873
HGNC: HGNC:2467
Homologene: 4795
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: Rutbc3, 1810012I01Rik, CIP85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105835
Homologene: 9249
Cdkl1
Name: cyclin-dependent kinase-like 1 (CDC2-related kinase)
Synonyms: 4933411O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Gm12253
Name: predicted gene 12253
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 624860
Homologene: 83331
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: very-kind, 2410012C07Rik, B830014K08Rik, VKIND
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76484
Homologene: 45138
Birc3
Name: baculoviral IAP repeat-containing 3
Synonyms: cIAP-2, IAP2, MIAP2, HIAP2, MIHC, RNF49, cIAP2, Api2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 11796
HGNC: HGNC:591
Homologene: 899
Rpe65
Name: retinal pigment epithelium 65
Synonyms: rd12, Mord1, A930029L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 19892
Homologene: 20108
Zadh2
Name: zinc binding alcohol dehydrogenase, domain containing 2
Synonyms: Pthr3, C530046K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225791
VEGA: 18
Homologene: 38387
Mzf1
Name: myeloid zinc finger 1
Synonyms: Zfp121, Zfp98, Znf42, Mzf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 109889
Homologene: 9633
Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226646
HGNC: HGNC:7708
Homologene: 56659
Cyp2w1
Name: cytochrome P450, family 2, subfamily w, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 545817
Homologene: 69239
Rassf10
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
Synonyms: 4632411J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 78748
Homologene: 121963
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 13,125,438 bp
  • A to T, chromosome 1 at 31,203,743 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • T to C, chromosome 1 at 171,236,353 bp
  • G to A, chromosome 2 at 10,249,188 bp
  • G to A, chromosome 2 at 20,849,934 bp
  • A to G, chromosome 2 at 41,284,185 bp
  • C to A, chromosome 2 at 121,204,318 bp
  • T to A, chromosome 3 at 20,108,869 bp
  • T to C, chromosome 3 at 159,601,583 bp
  • T to C, chromosome 4 at 57,103,528 bp
  • G to A, chromosome 4 at 155,418,696 bp
  • C to T, chromosome 5 at 104,009,878 bp
  • A to T, chromosome 5 at 139,356,439 bp
  • C to T, chromosome 6 at 137,514,307 bp
  • C to A, chromosome 7 at 13,052,771 bp
  • A to T, chromosome 7 at 13,450,914 bp
  • C to T, chromosome 7 at 112,955,368 bp
  • T to C, chromosome 7 at 127,136,331 bp
  • A to C, chromosome 7 at 139,923,735 bp
  • A to T, chromosome 8 at 70,391,255 bp
  • G to A, chromosome 8 at 72,709,449 bp
  • A to T, chromosome 9 at 7,851,051 bp
  • T to C, chromosome 9 at 42,338,994 bp
  • A to G, chromosome 9 at 58,249,539 bp
  • C to A, chromosome 9 at 108,105,635 bp
  • A to G, chromosome 9 at 108,561,097 bp
  • A to T, chromosome 9 at 110,246,526 bp
  • T to C, chromosome 10 at 106,819,511 bp
  • G to T, chromosome 11 at 58,440,020 bp
  • C to T, chromosome 11 at 78,009,404 bp
  • A to T, chromosome 12 at 69,756,564 bp
  • A to G, chromosome 12 at 70,211,017 bp
  • T to C, chromosome 13 at 55,474,227 bp
  • A to G, chromosome 13 at 102,770,784 bp
  • T to A, chromosome 13 at 112,531,673 bp
  • T to C, chromosome 15 at 81,011,345 bp
  • T to C, chromosome 16 at 35,622,631 bp
  • A to T, chromosome 16 at 94,456,789 bp
  • A to G, chromosome 18 at 84,095,207 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0905 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039063-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.