Strain Name:
C57BL/6J-MtgxR0918Btlr/Mmmh
Stock Number:
039068-MU
Citation ID:
RRID:MMRRC_039068-MU
Other Names:
R0918 (G1), C57BL/6J-MtgxR0918Btlr
Major Collection:

Strain Information

Aggf1
Name: angiogenic factor with G patch and FHA domains 1
Synonyms: 2310029P06Rik, VG5Q, 2010009L17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66549
Homologene: 41220
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SW1/SNF, Brg1, b2b508.1Clo, b2b692Clo, SNF2beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Ece1
Name: endothelin converting enzyme 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230857
HGNC: HGNC:3146
Homologene: 1068
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Drosha
Name: drosha, ribonuclease type III
Synonyms: Etohi2, Rnasen, 1110013A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Slc38a1
Name: solute carrier family 38, member 1
Synonyms: NAT2, SNAT1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105727
VEGA: 15
Homologene: 12745
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Acp1
Name: acid phosphatase 1, soluble
Synonyms: Lmptp, LMW-PTP, Acp-1, 4632432E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11431
VEGA: 12
HGNC: HGNC:122
Homologene: 38274
Cdhr5
Name: cadherin-related family member 5
Synonyms: 1810074H01Rik, Mupcdh, Mucdhl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72040
HGNC: HGNC:7521
Homologene: 69345
Sass6
Name: SAS-6 centriolar assembly protein
Synonyms: 2810453L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72776
Homologene: 45668
Timm21
Name: translocase of inner mitochondrial membrane 21
Synonyms: 2700002I20Rik, 1700034H14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67105
VEGA: 18
Homologene: 32211
Snx11
Name: sorting nexin 11
Synonyms: A930041K09Rik, 4933439F10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74479
Homologene: 12568
Pot1a
Name: protection of telomeres 1A
Synonyms: Pot1, 1500031H18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101185
Homologene: 32263
Slc38a6
Name: solute carrier family 38, member 6
Synonyms: EG625098
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 625098
Homologene: 27550
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Morn1
Name: MORN repeat containing 1
Synonyms: 2900057D20Rik, 4930417P05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76866
Homologene: 11757
Tnfaip2
Name: tumor necrosis factor, alpha-induced protein 2
Synonyms: Tnfip2, M-sec, Exoc3l3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21928
Homologene: 4583
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Adcy3
Name: adenylate cyclase 3
Synonyms: AC3, ACIII
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104111
HGNC: HGNC:234
Homologene: 2978
Poln
Name: DNA polymerase N
Synonyms: POL4P
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 272158
Homologene: 131253
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: Erk3-related, p63Mapk, A330097D03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
Cdh12
Name: cadherin 12
Synonyms: Br-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 215654
HGNC: HGNC:1751
Homologene: 37873
Tram2
Name: translocating chain-associating membrane protein 2
Synonyms: C330003D03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170829
Homologene: 8183
Gm13941
Name: predicted gene 13941
Type: Gene
Species: Mouse
Chromosome: 2
Pcdhb22
Name: protocadherin beta 22
Synonyms: PcdhbV, Pcdhb15
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Cerkl
Name: ceramide kinase-like
Synonyms: Rp26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228094
Homologene: 52396
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Or5p5
Name: olfactory receptor family 5 subfamily P member 5
Synonyms: MOR204-33P, GA_x6K02T2PBJ9-10144091-10145011, Olfr467
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257919
Homologene: 81542
Fes
Name: feline sarcoma oncogene
Synonyms: c-fes
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14159
HGNC: HGNC:3657
Homologene: 37563
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: Niemann-Pick disease, type C1, 9130221N23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Fbxo11
Name: F-box protein 11
Synonyms: Jf, GENA 104
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225055
Homologene: 11843
Ncan
Name: neurocan
Synonyms: Tgfbit, Cspg3, Cspg3-rs
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13004
HGNC: HGNC:2465
Homologene: 3229
Sult2a5
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
Synonyms: Gm15438, EG434264
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434264
Homologene: 37741
Cpz
Name: carboxypeptidase Z
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242939
HGNC: HGNC:2333
Homologene: 2709
Aadac
Name: arylacetamide deacetylase
Synonyms: 5033417E09Rik, Aada
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67758
HGNC: HGNC:17
Homologene: 37436
Tmem132a
Name: transmembrane protein 132A
Synonyms: 6720481D13Rik, Hspa5bp1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 98170
Homologene: 75076
Or5a3
Name: olfactory receptor family 5 subfamily A member 3
Synonyms: GA_x6K02T2RE5P-2753221-2754177, MOR215-2, Olfr1441
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258678
Homologene: 17343
Scnm1
Name: sodium channel modifier 1
Synonyms: 3110001I17Rik, Scnm1-ps
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69269
Homologene: 11431
Pla2g12b
Name: phospholipase A2, group XIIB
Synonyms: hlb218, 2010002E04Rik, Pla2g13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69836
Homologene: 11356
Gm10109
Name: predicted gene 10109
Synonyms: EG638411
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 638411
Or5ak4
Name: olfactory receptor family 5 subfamily AK member 4
Synonyms: GA_x6K02T2Q125-46808500-46807571, MOR203-7P, Olfr987
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257951
Homologene: 103791
Snrpa1
Name: small nuclear ribonucleoprotein polypeptide A'
Synonyms: U2 snRNP-A', 1500015N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68981
Homologene: 2325
Or14c44
Name: olfactory receptor family 14 subfamily C member 44
Synonyms: GA_x6K02T2NHDJ-9695951-9695766, MOR221-1P, MOR221-1P, MOR211-8P, MOR221-4, Olfr302, Olfr301, GA_x6K02T2NHDJ-9693313-9692378, Olfr1531-ps1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257958
Homologene: 128067
Syce1
Name: synaptonemal complex central element protein 1
Synonyms: 4933406J07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74075
Homologene: 77044
Gatd1
Name: glutamine amidotransferase like class 1 domain containing 1
Synonyms: Pddc1, D230016J19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213350
Homologene: 35234
Gm10337
Name: predicted gene 10337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 21,006,840 bp
  • C to T, chromosome 2 at 66,323,307 bp
  • A to G, chromosome 2 at 79,333,629 bp
  • A to G, chromosome 2 at 85,331,932 bp
  • G to C, chromosome 2 at 111,100,600 bp
  • T to G, chromosome 3 at 60,039,532 bp
  • A to T, chromosome 3 at 95,133,833 bp
  • G to A, chromosome 3 at 116,603,523 bp
  • A to G, chromosome 4 at 137,913,860 bp
  • T to G, chromosome 4 at 141,485,564 bp
  • T to A, chromosome 4 at 155,087,471 bp
  • C to A, chromosome 5 at 34,113,383 bp
  • A to G, chromosome 5 at 35,517,654 bp
  • G to A, chromosome 6 at 25,756,268 bp
  • T to A, chromosome 7 at 13,625,409 bp
  • C to T, chromosome 7 at 44,221,478 bp
  • A to G, chromosome 7 at 66,070,615 bp
  • G to T, chromosome 7 at 80,381,205 bp
  • A to G, chromosome 7 at 86,413,195 bp
  • T to C, chromosome 7 at 107,815,211 bp
  • T to C, chromosome 7 at 140,780,523 bp
  • T to A, chromosome 7 at 141,272,149 bp
  • C to G, chromosome 7 at 141,411,095 bp
  • T to G, chromosome 8 at 70,108,389 bp
  • C to T, chromosome 9 at 21,636,215 bp
  • A to G, chromosome 10 at 59,421,484 bp
  • T to C, chromosome 10 at 127,593,965 bp
  • G to A, chromosome 11 at 6,218,239 bp
  • G to A, chromosome 11 at 96,769,278 bp
  • A to G, chromosome 12 at 4,198,360 bp
  • T to C, chromosome 12 at 7,983,941 bp
  • G to T, chromosome 12 at 30,905,127 bp
  • T to A, chromosome 12 at 73,344,785 bp
  • T to A, chromosome 12 at 111,448,109 bp
  • A to G, chromosome 13 at 95,370,969 bp
  • T to C, chromosome 15 at 12,842,533 bp
  • G to A, chromosome 15 at 21,492,599 bp
  • A to G, chromosome 15 at 96,609,862 bp
  • T to C, chromosome 15 at 102,503,852 bp
  • T to C, chromosome 16 at 17,285,260 bp
  • G to A, chromosome 16 at 21,926,240 bp
  • A to T, chromosome 17 at 87,997,603 bp
  • T to C, chromosome 18 at 37,520,014 bp
  • C to T, chromosome 18 at 73,970,337 bp
  • G to C, chromosome 18 at 84,949,262 bp
  • A to G, chromosome 19 at 10,858,113 bp
  • A to G, chromosome 19 at 12,423,235 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0918 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039068-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.