Strain Name:
C57BL/6J-MtgxR0970Btlr/Mmmh
Stock Number:
039099-MU
Citation ID:
RRID:MMRRC_039099-MU
Other Names:
R0970 (G1), C57BL/6J-MtgxR0970Btlr
Major Collection:

Gene Information

Snx2
Name: sorting nexin 2
Synonyms: 0610030A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 67804
VEGA: 18
Homologene: 2332
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: R3hdm3, 0710001E13Rik, D9Bwg1012e, Tarpp, ARPP-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74100
Homologene: 32306
Cep70
Name: centrosomal protein 70
Synonyms: C030018L16Rik, 6720484E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68121
Homologene: 11387
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101772
Homologene: 75079
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: Zfp403, D330017P12Rik, DIF-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217039
Homologene: 11750
Clcn7
Name: chloride channel, voltage-sensitive 7
Synonyms: ClC-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 26373
HGNC: HGNC:2025
Homologene: 56546
Nav2
Name: neuron navigator 2
Synonyms: RAINB2, HELAD1, Unc53H2, 5330421F07Rik, POMFIL2, Rainb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 78286
Homologene: 52330
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 4921511H13Rik, 5730405K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 207932
Homologene: 45941
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 4432404J10Rik, 2010005B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66691
Homologene: 32637
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Dnec1, dynein heavy chain, retrograde transport, MAP1C, 9930018I23Rik, Swl, Loa, Dnchc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Prss16
Name: protease, serine 16 (thymus)
Synonyms: TSSP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 54373
HGNC: HGNC:9480
Homologene: 38106
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, 5230400C17Rik, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18711
Homologene: 32115
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226026
VEGA: 19
Homologene: 41009
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: Jmjd1b, 5830462I21Rik, JHDM2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 4921513O20Rik, D630001M17Rik, 9330188B09Rik, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66725
Homologene: 18982
Gpihbp1
Name: GPI-anchored HDL-binding protein 1
Synonyms: 1110002J19Rik, GPI-HBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 68453
Homologene: 136164
C87436
Name: expressed sequence C87436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232196
Homologene: 9897
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Piezo1, Fam38a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234839
Homologene: 124356
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Stradb
Name: STE20-related kinase adaptor beta
Synonyms: Als2cr2, PRO1038, D1Ucla2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227154
Homologene: 10237
Xylt1
Name: xylosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233781
Homologene: 32534
Cyp4b1
Name: cytochrome P450, family 4, subfamily b, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13120
HGNC: HGNC:2644
Homologene: 128045
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 81877
Homologene: 49589
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100559
Homologene: 137225
Dthd1
Name: death domain containing 1
Synonyms: Gm17384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100322896
Homologene: 123510
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
A3galt2
Name: alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)
Synonyms: iGb3, LOC215493
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 215493
Homologene: 16326
Eno3
Name: enolase 3, beta muscle
Synonyms: Eno-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13808
HGNC: HGNC:3354
Homologene: 68215
Atxn7l3
Name: ataxin 7-like 3
Synonyms: E030022H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217218
Homologene: 35401
Ppm1f
Name: protein phosphatase 1F (PP2C domain containing)
Synonyms: 1110021B16Rik, 4933427B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 68606
Homologene: 22828
Olfr669
Name: olfactory receptor 669
Synonyms: GA_x6K02T2PBJ9-7567376-7568329, MOR34-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259045
Homologene: 72057
Slc10a2
Name: solute carrier family 10, member 2
Synonyms: ASBT, 9130221J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20494
Homologene: 390
Amdhd2
Name: amidohydrolase domain containing 2
Synonyms: 5730457F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 245847
Homologene: 9311
Commd5
Name: COMM domain containing 5
Synonyms: D15Ertd81e, 2310065H03Rik, Hcarg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66398
Homologene: 8548
Tpm2
Name: tropomyosin 2, beta
Synonyms: Tpm-2, Trop-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22004
Homologene: 134309
Eva1a
Name: eva-1 homolog A (C. elegans)
Synonyms: Tmem166, Fam176a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232146
Homologene: 12969
Eepd1
Name: endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms: 2310005P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67484
Homologene: 12144
Gm17231
Name: predicted gene 17231
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Pmm2
Name: phosphomannomutase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 54128
HGNC: HGNC:9115
Homologene: 257
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 58,977,060 bp
  • T to A, chromosome 1 at 65,265,824 bp
  • T to A, chromosome 2 at 34,730,613 bp
  • T to A, chromosome 4 at 43,515,968 bp
  • G to A, chromosome 4 at 115,635,636 bp
  • T to C, chromosome 4 at 128,767,571 bp
  • T to C, chromosome 5 at 62,887,981 bp
  • T to G, chromosome 5 at 87,412,373 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • A to G, chromosome 6 at 82,092,103 bp
  • G to A, chromosome 6 at 86,447,328 bp
  • C to A, chromosome 7 at 49,584,153 bp
  • A to C, chromosome 7 at 104,939,077 bp
  • G to A, chromosome 7 at 117,634,736 bp
  • A to T, chromosome 7 at 144,595,571 bp
  • C to G, chromosome 8 at 5,105,115 bp
  • A to G, chromosome 8 at 11,415,438 bp
  • A to T, chromosome 8 at 122,486,810 bp
  • A to G, chromosome 9 at 25,603,426 bp
  • A to T, chromosome 9 at 57,833,551 bp
  • A to G, chromosome 9 at 99,275,599 bp
  • G to T, chromosome 9 at 109,103,263 bp
  • A to G, chromosome 9 at 112,136,448 bp
  • T to C, chromosome 11 at 70,660,802 bp
  • T to C, chromosome 11 at 84,862,312 bp
  • C to G, chromosome 11 at 102,292,435 bp
  • G to A, chromosome 12 at 110,636,509 bp
  • T to C, chromosome 13 at 22,005,117 bp
  • G to A, chromosome 15 at 75,597,946 bp
  • A to T, chromosome 15 at 76,900,685 bp
  • A to T, chromosome 15 at 91,729,169 bp
  • G to T, chromosome 16 at 8,642,776 bp
  • T to C, chromosome 16 at 16,903,593 bp
  • A to T, chromosome 16 at 90,769,447 bp
  • C to T, chromosome 17 at 24,156,570 bp
  • T to C, chromosome 17 at 25,151,234 bp
  • C to G, chromosome 17 at 34,698,943 bp
  • T to C, chromosome 18 at 34,809,039 bp
  • T to C, chromosome 18 at 53,210,690 bp
  • T to A, chromosome 19 at 23,238,998 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0970 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039099-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.