Strain Name:
C57BL/6J-MtgxR1005Btlr/Mmmh
Stock Number:
039115-MU
Citation ID:
RRID:MMRRC_039115-MU
Other Names:
R1005 (G1), C57BL/6J-MtgxR1005Btlr
Major Collection:

Strain Information

Mc3r
Name: melanocortin 3 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17201
HGNC: HGNC:6931
Homologene: 7412
Enah
Name: ENAH actin regulator
Synonyms: Mena, Ndpp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13800
Homologene: 134005
Smarcad1
Name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Synonyms: D6Pas1, Etl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13990
Homologene: 5301
Iars
Name: isoleucine-tRNA synthetase
Synonyms: E430001P04Rik, 2510016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100683
Homologene: 39246
Rab28
Name: RAB28, member RAS oncogene family
Synonyms: 2700023P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100972
HGNC: HGNC:9768
Homologene: 3135
Sptb
Name: spectrin beta, erythrocytic
Synonyms: Spnb-1, spectrin R, D330027P03Rik, LOC383567, brain erythroid spectrin (235E), Spnb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20741
Homologene: 295
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Adam27, Dtgn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Anxa6
Name: annexin A6
Synonyms: Camb, Anx6, AnxVI, Annexin VI, Cabm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11749
HGNC: HGNC:544
Homologene: 55558
Amph
Name: amphiphysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Ston2
Name: stonin 2
Synonyms: 4933401N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 108800
Homologene: 84338
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Anpep
Name: alanyl (membrane) aminopeptidase
Synonyms: Cd13, aminopeptidase N, Apn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Ttc8
Name: tetratricopeptide repeat domain 8
Synonyms: 0610012F22Rik, BBS8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76260
Homologene: 14988
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, VEGFR-1, VEGFR1, Flt-1, sFlt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Stard9
Name: START domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Rhobtb2
Name: Rho-related BTB domain containing 2
Synonyms: Dbc2, E130206H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 246710
VEGA: 14
Homologene: 22873
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox-1, Aox2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19886
Homologene: 2207
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, AN2, 4732461B14Rik, Cspg4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Prrt3
Name: proline-rich transmembrane protein 3
Synonyms: B230206N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 210673
Homologene: 52099
Fam171a2
Name: family with sequence similarity 171, member A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217219
Homologene: 19144
Adck1
Name: aarF domain containing kinase 1
Synonyms: 2610005A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72113
VEGA: 12
Homologene: 6493
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Synonyms: small heterodimer partner, SHP-1, SHP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 23957
HGNC: HGNC:7961
Homologene: 8030
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: mOAT6 related protein, AB056442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 171405
Homologene: 77136
Gbp2
Name: guanylate binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14469
Homologene: 10289
Fpr-rs3
Name: formyl peptide receptor, related sequence 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14290
Homologene: 130087
Gm6871
Name: predicted gene 6871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102642386
Gm9742
Name: predicted gene 9742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 791083
VEGA: 13
Slfn5
Name: schlafen 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327978
Homologene: 18839
Snx31
Name: sorting nexin 31
Synonyms: 4631426E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66696
Homologene: 23551
Prl7a1
Name: prolactin family 7, subfamily a, member 1
Synonyms: PLP-G, PLP-E, Prlpg, Prlpe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19113
HGNC: HGNC:9445
Homologene: 136279
Klk1b8
Name: kallikrein 1-related peptidase b8
Synonyms: TADG14, mGK-8, Klk8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16624
Homologene: 68141
Or1a1b
Name: olfactory receptor family 1 subfamily A member 1B
Synonyms: MOR125-1, GA_x6K02T2P1NL-4359899-4358958, Olfr43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258706
Homologene: 8219
Cbx2
Name: chromobox 2
Synonyms: M33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12416
HGNC: HGNC:1552
Homologene: 7256
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,065,352 bp
  • A to T, chromosome 1 at 181,961,930 bp
  • C to A, chromosome 2 at 120,673,636 bp
  • A to G, chromosome 2 at 172,249,563 bp
  • T to C, chromosome 3 at 142,630,501 bp
  • G to T, chromosome 4 at 133,553,474 bp
  • A to G, chromosome 5 at 41,698,383 bp
  • A to G, chromosome 5 at 144,805,727 bp
  • G to T, chromosome 5 at 147,681,885 bp
  • T to C, chromosome 6 at 41,688,617 bp
  • C to T, chromosome 6 at 65,108,727 bp
  • G to A, chromosome 6 at 113,494,778 bp
  • A to T, chromosome 7 at 41,546,258 bp
  • T to A, chromosome 7 at 43,954,334 bp
  • C to T, chromosome 7 at 79,838,256 bp
  • T to A, chromosome 8 at 16,288,693 bp
  • T to C, chromosome 8 at 24,665,514 bp
  • A to G, chromosome 9 at 37,408,251 bp
  • G to A, chromosome 9 at 39,593,733 bp
  • A to G, chromosome 9 at 56,888,736 bp
  • T to G, chromosome 9 at 111,333,721 bp
  • T to A, chromosome 10 at 52,128,405 bp
  • A to T, chromosome 11 at 55,001,218 bp
  • A to G, chromosome 11 at 74,207,136 bp
  • T to A, chromosome 11 at 82,960,158 bp
  • T to C, chromosome 11 at 102,440,181 bp
  • A to G, chromosome 11 at 119,028,574 bp
  • C to T, chromosome 12 at 76,601,859 bp
  • G to A, chromosome 12 at 88,402,102 bp
  • T to C, chromosome 12 at 91,648,848 bp
  • T to C, chromosome 12 at 98,937,144 bp
  • T to C, chromosome 13 at 8,035,215 bp
  • G to A, chromosome 13 at 19,142,028 bp
  • G to A, chromosome 13 at 27,642,446 bp
  • T to C, chromosome 13 at 49,687,445 bp
  • A to G, chromosome 14 at 69,798,277 bp
  • A to G, chromosome 15 at 36,517,691 bp
  • T to C, chromosome 17 at 20,624,084 bp
  • A to T, chromosome 19 at 7,926,751 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1005 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039115-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.