Strain Name:
C57BL/6J-MtgxR1018Btlr/Mmmh
Stock Number:
039122-MU
Citation ID:
RRID:MMRRC_039122-MU
Other Names:
R1018 (G1), C57BL/6J-MtgxR1018Btlr
Major Collection:

Gene Information

Dst
Name: dystonin
Synonyms: Bpag1, Bpag, A830042E19Rik, ah, nmf203, bullous pemphigoid antigen 1, athetoid, BPAG1-n, Macf2, 2310001O04Rik, BPAG1, bullous pemphigoid antigen 1, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Upf1
Name: UPF1 regulator of nonsense transcripts homolog (yeast)
Synonyms: Rent1, PNORF-1, B430202H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19704
HGNC: HGNC:9962
Homologene: 2185
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81000
Homologene: 56698
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: PTP-P19, P19-PTP, PTP-PEST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Arl8b
Name: ADP-ribosylation factor-like 8B
Synonyms: Arl10c, 3100002J04Rik, 2610313E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67166
Homologene: 10056
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103554
Homologene: 113742
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, 1190005N23Rik, Sfrs8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231769
Homologene: 134548
Zfp341
Name: zinc finger protein 341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228807
Homologene: 13127
Plxna1
Name: plexin A1
Synonyms: 2600013D04Rik, Plxn1, NOV, PlexA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Eed
Name: embryonic ectoderm development
Synonyms: l(7)5Rn, l7Rn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13626
HGNC: HGNC:3188
Homologene: 2814
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108989
Homologene: 37753
Stam
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Synonyms: STAM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20844
Homologene: 37788
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75956
Wapl
Name: WAPL cohesin release factor
Synonyms: Wapal, A530089A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218914
Homologene: 41002
Prom1
Name: prominin 1
Synonyms: Prom-1, CD133, AC133, Prom, 4932416E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: Solo, 6720464I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Lrig1
Name: leucine-rich repeats and immunoglobulin-like domains 1
Synonyms: LIG-1, Img
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16206
Homologene: 7380
Unc5a
Name: unc-5 netrin receptor A
Synonyms: Unc5h1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107448
Homologene: 41474
Psap
Name: prosaposin
Synonyms: SGP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19156
HGNC: HGNC:9498
Homologene: 37680
Tmem131
Name: transmembrane protein 131
Synonyms: YR-23, 2610524E03Rik, Neg, D1Bwg0491e, Rw1, CC28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56030
Homologene: 32428
Nsd2
Name: nuclear receptor binding SET domain protein 2
Synonyms: Whsc1, Whsc1l, 5830445G22Rik, D030027O06Rik, C130020C13Rik, D930023B08Rik, 9430010A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 107823
Homologene: 26175
Car9
Name: carbonic anhydrase 9
Synonyms: MN/CA9, CAIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Atp5pb
Name: ATP synthase peripheral stalk-membrane subunit b
Synonyms: Atp5f1, C76477
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11950
HGNC: HGNC:840
Homologene: 1275
Hspa13
Name: heat shock protein 70 family, member 13
Synonyms: 60kDa, B230217N24Rik, Stch, 1600002I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110920
Homologene: 5062
P3h1
Name: prolyl 3-hydroxylase 1
Synonyms: Leprecan, Gros1, Lepre1, 2410024C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56401
Homologene: 10509
Qtrt2
Name: queuine tRNA-ribosyltransferase accessory subunit 2
Synonyms: 3110012M05Rik, 4930470H18Rik, Qrtr2, Qtrtd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106248
Homologene: 41576
Efl1
Name: elongation factor like GTPase 1
Synonyms: 6030468D11Rik, Eftud1, D7Ertd791e, 4932434J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101592
Homologene: 11599
Il16
Name: interleukin 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16170
HGNC: HGNC:5980
Homologene: 18157
Myo7a
Name: myosin VIIA
Synonyms: Myo7, USH1B, Hdb, polka, nmf371
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Large2
Name: LARGE xylosyl- and glucuronyltransferase 2
Synonyms: Gyltl1b, 5730485C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228366
Homologene: 27362
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG667069, EG620718
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 667069
Homologene: 129754
Uba5
Name: ubiquitin-like modifier activating enzyme 5
Synonyms: Ube1dc1, 5730525G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66663
Homologene: 11738
Cgnl1
Name: cingulin-like 1
Synonyms: 4933421H10Rik, 9930020M10Rik, Jacop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68178
Homologene: 41901
Ankrd36
Name: ankyrin repeat domain 36
Synonyms: 1700008J08Rik, GC3, 1700012M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76389
Homologene: 137366
Kif14
Name: kinesin family member 14
Synonyms: N-3 kinesin, D1Ertd367e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381293
Homologene: 8916
Ppp1r32
Name: protein phosphatase 1, regulatory subunit 32
Synonyms: IIIG9S, IIIG9, IIIG9L, 4930579J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Dffry, Fafl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 107868
Homologene: 68408
Slc24a5
Name: solute carrier family 24, member 5
Synonyms: NCKX5, F630045L20Rik, Oca6, NCX5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 317750
Homologene: 18400
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 236573
Homologene: 128731
Epx
Name: eosinophil peroxidase
Synonyms: EPO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13861
HGNC: HGNC:3423
Homologene: 20144
Abca7
Name: ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms: Abc51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Zfp957
Name: zinc finger protein 957
Synonyms: AU017455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105590
Fbxw20
Name: F-box and WD-40 domain protein 20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434440
Homologene: 110776
Olfr1234
Name: olfactory receptor 1234
Synonyms: GA_x6K02T2Q125-50805620-50804676, MOR231-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258975
Homologene: 128156
Tbx6
Name: T-box 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21389
Homologene: 3389
Zfp358
Name: zinc finger protein 358
Synonyms: Zfend
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 140482
Homologene: 9996
Cnn2
Name: calponin 2
Synonyms: Calpo2, h2-calponin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12798
HGNC: HGNC:2156
Homologene: 3215
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,201,259 bp
  • A to G, chromosome 1 at 34,194,093 bp
  • A to C, chromosome 1 at 36,794,819 bp
  • G to A, chromosome 1 at 136,495,841 bp
  • T to A, chromosome 1 at 150,442,183 bp
  • T to C, chromosome 2 at 14,117,374 bp
  • C to A, chromosome 2 at 89,363,179 bp
  • T to C, chromosome 2 at 92,370,677 bp
  • T to C, chromosome 2 at 125,068,907 bp
  • A to T, chromosome 2 at 154,646,052 bp
  • T to A, chromosome 3 at 64,556,840 bp
  • A to T, chromosome 3 at 105,954,172 bp
  • G to T, chromosome 4 at 43,512,439 bp
  • C to A, chromosome 4 at 119,237,907 bp
  • A to T, chromosome 5 at 21,029,869 bp
  • A to G, chromosome 5 at 33,843,241 bp
  • A to T, chromosome 5 at 44,029,714 bp
  • T to A, chromosome 5 at 105,080,260 bp
  • A to G, chromosome 5 at 129,554,576 bp
  • A to G, chromosome 6 at 89,342,960 bp
  • G to A, chromosome 6 at 94,622,602 bp
  • T to A, chromosome 6 at 108,818,611 bp
  • T to A, chromosome 7 at 82,763,013 bp
  • T to C, chromosome 7 at 83,674,538 bp
  • T to C, chromosome 7 at 89,967,811 bp
  • T to A, chromosome 7 at 98,107,005 bp
  • T to A, chromosome 7 at 126,783,192 bp
  • C to A, chromosome 8 at 3,496,843 bp
  • C to T, chromosome 8 at 40,796,109 bp
  • G to T, chromosome 8 at 70,338,906 bp
  • A to G, chromosome 9 at 71,726,058 bp
  • T to C, chromosome 9 at 104,049,903 bp
  • C to A, chromosome 9 at 106,712,390 bp
  • T to A, chromosome 9 at 109,221,336 bp
  • T to G, chromosome 10 at 60,300,811 bp
  • T to C, chromosome 10 at 79,993,563 bp
  • G to T, chromosome 10 at 80,001,491 bp
  • C to T, chromosome 11 at 5,646,876 bp
  • C to T, chromosome 11 at 30,804,310 bp
  • T to C, chromosome 11 at 87,869,303 bp
  • T to A, chromosome 13 at 54,990,952 bp
  • T to C, chromosome 14 at 34,691,906 bp
  • C to A, chromosome 14 at 79,212,742 bp
  • T to A, chromosome 15 at 27,871,171 bp
  • T to A, chromosome 16 at 43,878,000 bp
  • C to A, chromosome 16 at 75,761,276 bp
  • T to C, chromosome 17 at 23,822,540 bp
  • A to T, chromosome 19 at 10,479,460 bp
  • A to G, chromosome Y at 1,341,414 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1018 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039122-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.