Strain Name:
C57BL/6J-MtgxR1052Btlr/Mmmh
Stock Number:
039142-MU
Citation ID:
RRID:MMRRC_039142-MU
Other Names:
R1052 (G1), C57BL/6J-MtgxR1052Btlr
Major Collection:

Strain Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: B130038B15Rik, TonEBP, nfatz, OREBP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Casq2
Name: calsequestrin 2
Synonyms: cCSQ, ESTM52, Csq2, cardiac calsequestrin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12373
HGNC: HGNC:1513
Homologene: 20330
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SW1/SNF, Brg1, b2b508.1Clo, b2b692Clo, SNF2beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Galnt10
Name: polypeptide N-acetylgalactosaminyltransferase 10
Synonyms: C330012K04Rik, GalNAc-T10, Galnt9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171212
Homologene: 14924
Hspa5
Name: heat shock protein 5
Synonyms: XAP-1 antigen, mBiP, D2Wsu141e, Grp78, Sez7, Hsce70, baffled, 78kDa, D2Wsu17e, Bip
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14828
HGNC: HGNC:5238
Homologene: 3908
Gnpat
Name: glyceronephosphate O-acyltransferase
Synonyms: D1Ertd819e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14712
HGNC: HGNC:4416
Homologene: 40716
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, D2Ertd145e, 6530403D07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
Kras
Name: Kirsten rat sarcoma viral oncogene homolog
Synonyms: Kras-2, Kras2, Ki-ras, K-ras
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16653
HGNC: HGNC:6407
Homologene: 37990
Tmem43
Name: transmembrane protein 43
Synonyms: 1200015A22Rik, LUMA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74122
Homologene: 11532
Atp5f1b
Name: ATP synthase F1 subunit beta
Synonyms: Atp5b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11947
HGNC: HGNC:830
Homologene: 1273
Cir1
Name: corepressor interacting with RBPJ, 1
Synonyms: CIR, 1700023B02Rik, 2810021A19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66935
Homologene: 3589
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329559
Homologene: 11129
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: Zfp161, ZF5, b2b1982Clo
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22666
Homologene: 2560
Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
Synonyms: 4633401G24Rik, beta1 integrin, CD29, Fnrb, Gm9863
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16412
HGNC: HGNC:6153
Homologene: 22999
Adam19
Name: ADAM metallopeptidase domain 19
Synonyms: Mltnb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11492
HGNC: HGNC:197
Homologene: 74925
R3hcc1l
Name: R3H domain and coiled-coil containing 1 like
Synonyms: D19Ertd386e, 1700036B12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52013
Homologene: 8707
Apba3
Name: amyloid beta precursor protein binding family A member 3
Synonyms: Mint-3, neuronal munc18-1-interacting protein 3, neuron-specific X11L2 protein, X11gamma, Mint 3, lin-10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57267
VEGA: 10
HGNC: HGNC:580
Homologene: 3591
AW554918
Name: expressed sequence AW554918
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225289
Homologene: 52652
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269224
Homologene: 9038
Zfp874a
Name: zinc finger protein 874a
Synonyms: Rslcan15, C330011K17Rik, Zfp874
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238692
Homologene: 135597
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Myo16
Name: myosin XVI
Synonyms: BM140241, Nyap3, C230040D10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244281
Homologene: 34710
Acad10
Name: acyl-Coenzyme A dehydrogenase family, member 10
Synonyms: 2410021P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71985
Homologene: 49825
Arhgap20
Name: Rho GTPase activating protein 20
Synonyms: 6530403F17Rik, A530023E23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244867
Homologene: 18938
Mlxipl
Name: MLX interacting protein-like
Synonyms: WS-bHLH, bHLHd14, Wbscr14, ChREBP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58805
Homologene: 32507
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Slc35b4
Name: solute carrier family 35, member B4
Synonyms: 4930474D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58246
Homologene: 5799
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Csf3r
Name: colony stimulating factor 3 receptor
Synonyms: Csfgr, G-CSFR, Cd114
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12986
HGNC: HGNC:2439
Homologene: 601
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Arsa
Name: arylsulfatase A
Synonyms: ASA, As-2, As2, AS-A
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11883
HGNC: HGNC:713
Homologene: 20138
Gm13941
Name: predicted gene 13941
Type: Gene
Species: Mouse
Chromosome: 2
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215772
Homologene: 100289
Gstm7
Name: glutathione S-transferase, mu 7
Synonyms: 0610005A07Rik, Cd203c
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68312
HGNC: HGNC:4634
Homologene: 41816
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277667
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
Prrt4
Name: proline-rich transmembrane protein 4
Synonyms: D330027H18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101359
Homologene: 46116
Abtb2
Name: ankyrin repeat and BTB domain containing 2
Synonyms: BPOZ-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99382
Homologene: 15904
Pla2g4c
Name: phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms: CPLA2-gamma
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232889
HGNC: HGNC:9037
Homologene: 115256
Or6p1
Name: olfactory receptor family 6 subfamily P member 1
Synonyms: Olfr414, MOR103-10, GA_x6K02T2P20D-20749615-20748662
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258756
Homologene: 17383
Pdlim3
Name: PDZ and LIM domain 3
Synonyms: ALP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 53318
Homologene: 75063
Serpinb8
Name: serine (or cysteine) peptidase inhibitor, clade B, member 8
Synonyms: CAP-2, NK10, ovalbumin, Spi8, CAP2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20725
HGNC: HGNC:8952
Homologene: 74445
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 9130206N08Rik, 2010013I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103406
Homologene: 88124
Krt23
Name: keratin 23
Synonyms: CK23, K23, Krt1-23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94179
HGNC: HGNC:6438
Homologene: 9172
Cerk
Name: ceramide kinase
Synonyms: D330016D08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223753
Homologene: 11247
Pcdhb17
Name: protocadherin beta 17
Synonyms: PcdhbQ, Pcdhb16
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93888
Homologene: 81881
Tchhl1
Name: trichohyalin-like 1
Synonyms: S100a17, Thhl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71325
Homologene: 84625
Dzank1
Name: double zinc ribbon and ankyrin repeat domains 1
Synonyms: 6330439K17Rik, Ankrd64, 2810039F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241688
Homologene: 10037
Slc2a13
Name: solute carrier family 2 (facilitated glucose transporter), member 13
Synonyms: A630029G22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239606
Homologene: 43139
Nlrp4f
Name: NLR family, pyrin domain containing 4F
Synonyms: Nalp4f, C330026N02Rik, Nalp-kappa
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97895
VEGA: 13
Homologene: 87252
Cyp3a41a
Name: cytochrome P450, family 3, subfamily a, polypeptide 41A
Synonyms: steroid inducible, Cyp3a41
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53973
HGNC: HGNC:2638
Homologene: 133568
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210503
Homologene: 138402
Or5al5
Name: olfactory receptor family 5 subfamily AL member 5
Synonyms: Olfr1517, MOR185-9P, MOR185-5, MOR185-5, MOR185-5, Olfr1039, GA_x6K02T2Q125-47600809-47599850
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257950
Homologene: 79382
Bmp4
Name: bone morphogenetic protein 4
Synonyms: Bmp-4, Bmp2b, Bmp2b1, Bmp2b-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12159
HGNC: HGNC:1071
Homologene: 7247
Gm6729
Name: predicted gene 6729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 627035
VEGA: 10
Homologene: 141143
Gm17661
Name: predicted gene, 17661
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Cdk5rap1
Name: CDK5 regulatory subunit associated protein 1
Synonyms: 2310066P17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66971
Homologene: 9502
Slc35f6
Name: solute carrier family 35, member F6
Synonyms: p40, 5730478O19Rik, 4930471M23Rik, Tango9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74919
Homologene: 9896
Cyp8b1
Name: cytochrome P450, family 8, subfamily b, polypeptide 1
Synonyms: sterol 12-alpha-hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13124
HGNC: HGNC:2653
Homologene: 3233
Mboat2
Name: membrane bound O-acyltransferase domain containing 2
Synonyms: 2810049G06Rik, Oact2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67216
VEGA: 12
Homologene: 6971
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 93,330,827 bp
  • A to T, chromosome 1 at 107,604,754 bp
  • A to T, chromosome 1 at 174,431,135 bp
  • A to G, chromosome 2 at 31,928,802 bp
  • A to G, chromosome 2 at 34,775,098 bp
  • A to C, chromosome 2 at 52,111,562 bp
  • A to C, chromosome 2 at 73,287,643 bp
  • A to G, chromosome 2 at 86,131,571 bp
  • GA to GAA, chromosome 2 at 90,917,709 bp
  • A to T, chromosome 2 at 103,705,072 bp
  • A to T, chromosome 2 at 111,104,768 bp
  • A to T, chromosome 2 at 144,513,445 bp
  • A to G, chromosome 2 at 150,786,938 bp
  • A to T, chromosome 2 at 154,360,599 bp
  • GTCCTCCTCCTCCTCCTC to GTCCTCCTCCTCCTC, chromosome 2 at 164,907,468 bp
  • G to A, chromosome 3 at 93,470,213 bp
  • T to C, chromosome 3 at 102,144,234 bp
  • T to C, chromosome 3 at 107,926,950 bp
  • A to T, chromosome 4 at 126,042,988 bp
  • T to C, chromosome 4 at 139,455,460 bp
  • T to C, chromosome 4 at 143,696,907 bp
  • T to C, chromosome 5 at 30,655,873 bp
  • G to A, chromosome 5 at 121,649,541 bp
  • T to A, chromosome 5 at 135,113,710 bp
  • A to T, chromosome 5 at 145,705,811 bp
  • G to T, chromosome 5 at 150,982,520 bp
  • G to T, chromosome 6 at 29,169,814 bp
  • A to T, chromosome 6 at 34,161,684 bp
  • T to A, chromosome 6 at 91,485,442 bp
  • A to G, chromosome 6 at 119,300,333 bp
  • A to T, chromosome 6 at 145,225,210 bp
  • T to A, chromosome 7 at 13,343,409 bp
  • C to A, chromosome 7 at 29,096,258 bp
  • T to A, chromosome 8 at 10,570,181 bp
  • T to A, chromosome 8 at 45,896,800 bp
  • T to A, chromosome 8 at 107,338,283 bp
  • T to C, chromosome 8 at 124,877,507 bp
  • T to A, chromosome 8 at 124,878,516 bp
  • T to G, chromosome 8 at 128,713,305 bp
  • T to C, chromosome 9 at 21,686,290 bp
  • C to A, chromosome 9 at 51,846,270 bp
  • A to G, chromosome 9 at 121,915,282 bp
  • T to C, chromosome 10 at 10,442,613 bp
  • A to T, chromosome 10 at 39,092,245 bp
  • C to A, chromosome 10 at 81,239,422 bp
  • T to C, chromosome 10 at 81,270,958 bp
  • T to A, chromosome 10 at 86,540,935 bp
  • A to G, chromosome 10 at 128,090,052 bp
  • T to C, chromosome 11 at 46,127,265 bp
  • T to A, chromosome 11 at 57,771,595 bp
  • T to C, chromosome 11 at 99,478,219 bp
  • C to T, chromosome 11 at 113,838,646 bp
  • T to C, chromosome 12 at 24,946,528 bp
  • A to G, chromosome 13 at 65,185,083 bp
  • T to G, chromosome 13 at 67,442,420 bp
  • T to C, chromosome 14 at 46,383,903 bp
  • G to C, chromosome 15 at 86,149,364 bp
  • A to T, chromosome 15 at 89,475,177 bp
  • A to G, chromosome 15 at 90,935,650 bp
  • A to G, chromosome 15 at 91,412,160 bp
  • T to A, chromosome 17 at 21,396,829 bp
  • C to A, chromosome 17 at 69,388,502 bp
  • T to A, chromosome 17 at 71,101,211 bp
  • G to A, chromosome 18 at 25,420,010 bp
  • A to G, chromosome 18 at 37,486,846 bp
  • T to A, chromosome 19 at 42,563,654 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1052 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039142-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.