Strain Name:
C57BL/6J-MtgxR1066Btlr/Mmmh
Stock Number:
039152-MU
Citation ID:
RRID:MMRRC_039152-MU
Other Names:
R1066 (G1), C57BL/6J-MtgxR1066Btlr
Major Collection:

Strain Information

Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p50alpha, PI3K, p85alpha, p55alpha
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Phf14
Name: PHD finger protein 14
Synonyms: 5730446A07Rik, 1110001C23Rik, 4932409F11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75725
Homologene: 8775
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Taok1
Name: TAO kinase 1
Synonyms: 2810468K05Rik, D130018F14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216965
Homologene: 27041
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: UBA2, Arx, anthracycline-associated resistance, SAE2, Sumo-1 activating enzyme subunit 2, Uble1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50995
Homologene: 4018
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Synonyms: 17[b]-HSD, MFE-2, perMFE-2, multifunctional protein 2, MFP2, Mfp-2, D-bifunctional protein
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15488
HGNC: HGNC:5213
Homologene: 358
Pals2
Name: protein associated with LIN7 2, MAGUK family member
Synonyms: Mpp6, P55t, Pals2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56524
Homologene: 22976
Reep3
Name: receptor accessory protein 3
Synonyms: D10Ucla1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28193
VEGA: 10
Homologene: 37401
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 1700034M03Rik, 8430415E05Rik, Ccdc132
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73288
Homologene: 11498
Brf2
Name: BRF2, RNA polymerase III transcription initiation factor 50kDa subunit
Synonyms: 2700059M06Rik, BRFU, TFIIIB50, 5730512K07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66653
Homologene: 10127
Boc
Name: BOC cell adhesion associated, oncogene regulated
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117606
Homologene: 32819
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Mkln1
Name: muskelin 1, intracellular mediator containing kelch motifs
Synonyms: A130067F06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27418
HGNC: HGNC:7109
Homologene: 8305
Znhit6
Name: zinc finger, HIT type 6
Synonyms: 2410019A14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229937
Homologene: 32378
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: D5Ertd591e, 2410140K03Rik, A630018G05Rik, 3110031A07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: 2900022L05Rik, Dnhd3, Dnahc2, D330014H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Klhl42
Name: kelch-like 42
Synonyms: C230080I20Rik, Klhdc5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232539
Homologene: 45842
Gsdmc2
Name: gasdermin C2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 331063
HGNC: HGNC:7151
Homologene: 69487
Myo15b
Name: myosin XVB
Synonyms: LOC217328, E330039G21Rik, LOC380737
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Gm9873
Name: predicted gene 9873
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Sdcbp
Name: syndecan binding protein
Synonyms: Sycl, syntenin, syntenin-1, syndecan interacting protein, MDA-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53378
Homologene: 4110
Adarb2
Name: adenosine deaminase, RNA-specific, B2
Synonyms: RED2, Adar3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94191
HGNC: HGNC:227
Homologene: 10276
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Mrvi1, Ris1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
BB014433
Name: expressed sequence BB014433
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434285
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: Semai, M-Sema F, Semacl1, Semaf, Semacl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20353
Homologene: 23047
Or5b113
Name: olfactory receptor family 5 subfamily B member 113
Synonyms: GA_x6K02T2RE5P-3695694-3696620, MOR202-15, Olfr1467
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258686
Homologene: 133888
Rps26-ps1
Name: ribosomal protein S26, pseudogene 1
Synonyms: Gm10070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100042812
Akr1b1
Name: aldo-keto reductase family 1 member B
Synonyms: Ahr-1, Ahr1, Aldr1, Aldor1, ALR2, AR, Akr1b3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11677
HGNC: HGNC:381
Homologene: 133743
Adamts8
Name: ADAM metallopeptidase with thrombospondin type 1 motif 8
Synonyms: METH2, METH-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30806
HGNC: HGNC:224
Homologene: 5108
Ces3a
Name: carboxylesterase 3A
Synonyms: Es-male carboxylesterase, Es31
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382053
HGNC: HGNC:1865
Homologene: 84407
Tedc2
Name: tubulin epsilon and delta complex 2
Synonyms: 1600002H07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72016
Homologene: 45943
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320452
Homologene: 27943
Msantd5f6
Name: Myb/SANT DNA binding domain containing 5 family member 6
Synonyms: Gm11487
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433719
Homologene: 128423
Slfnl1
Name: schlafen like 1
Synonyms: 4933406A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194219
Homologene: 44913
Slc25a18
Name: solute carrier family 25 (mitochondrial carrier), member 18
Synonyms: 1500015I14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71803
Homologene: 57151
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,550,200 bp
  • T to C, chromosome 1 at 135,970,725 bp
  • T to G, chromosome 2 at 169,021,057 bp
  • T to C, chromosome 3 at 38,957,227 bp
  • T to A, chromosome 3 at 145,578,497 bp
  • T to G, chromosome 4 at 6,385,120 bp
  • C to A, chromosome 4 at 73,401,829 bp
  • A to G, chromosome 4 at 120,535,832 bp
  • G to T, chromosome 5 at 22,034,664 bp
  • A to T, chromosome 5 at 143,718,041 bp
  • A to C, chromosome 6 at 3,533,565 bp
  • T to A, chromosome 6 at 11,987,255 bp
  • A to C, chromosome 6 at 31,418,987 bp
  • C to T, chromosome 6 at 34,310,499 bp
  • A to T, chromosome 6 at 50,145,867 bp
  • A to G, chromosome 6 at 120,788,288 bp
  • T to C, chromosome 6 at 147,107,899 bp
  • A to T, chromosome 7 at 34,158,822 bp
  • G to T, chromosome 7 at 100,318,063 bp
  • C to A, chromosome 7 at 110,927,791 bp
  • T to A, chromosome 7 at 120,061,009 bp
  • C to T, chromosome 8 at 15,042,185 bp
  • T to C, chromosome 8 at 27,123,946 bp
  • T to A, chromosome 8 at 90,986,136 bp
  • T to A, chromosome 8 at 105,055,656 bp
  • T to C, chromosome 8 at 107,439,337 bp
  • T to A, chromosome 9 at 30,956,541 bp
  • G to T, chromosome 10 at 67,034,666 bp
  • T to C, chromosome 10 at 68,098,356 bp
  • C to T, chromosome 10 at 130,446,276 bp
  • C to A, chromosome 11 at 69,447,819 bp
  • T to A, chromosome 11 at 77,559,729 bp
  • A to T, chromosome 11 at 115,879,751 bp
  • T to A, chromosome 12 at 95,779,059 bp
  • T to G, chromosome 13 at 8,757,323 bp
  • T to A, chromosome 13 at 101,688,663 bp
  • A to T, chromosome 15 at 8,157,760 bp
  • A to G, chromosome 15 at 47,913,965 bp
  • T to A, chromosome 15 at 63,825,050 bp
  • T to C, chromosome 16 at 44,490,684 bp
  • T to A, chromosome 17 at 24,216,317 bp
  • C to A, chromosome 17 at 24,216,318 bp
  • T to A, chromosome 18 at 50,142,648 bp
  • G to T, chromosome 19 at 12,501,009 bp
  • T to C, chromosome 19 at 13,365,087 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1066 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039152-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.