Strain Name:
C57BL/6J-MtgxR1075Btlr/Mmmh
Stock Number:
039161-MU
Citation ID:
RRID:MMRRC_039161-MU
Other Names:
R1075 (G1), C57BL/6J-MtgxR1075Btlr
Major Collection:

Gene Information

Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Enah
Name: ENAH actin regulator
Synonyms: Mena, Ndpp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13800
Homologene: 134005
Fbxl3
Name: F-box and leucine-rich repeat protein 3
Synonyms: Fbl3a, Fbxl3a, Ovtm, Play68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50789
Homologene: 8127
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 0610009J05Rik, 2610019N13Rik, Sfrs11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69207
Homologene: 36164
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: B3RP, Ae2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20535
Homologene: 128699
Apbb2
Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms: TR2L, Rirl1, 2310007D03Rik, Zfra, FE65L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Usf1
Name: upstream transcription factor 1
Synonyms: upstream stimulatory factor, bHLHb11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22278
Homologene: 31426
Supt20
Name: SPT20 SAGA complex component
Synonyms: p38 interacting protein, p38IP, D3Ertd300e, Fam48a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56790
Homologene: 134155
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Fam81a
Name: family with sequence similarity 81, member A
Synonyms: 6430514L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76886
Homologene: 17584
Bdkrb1
Name: bradykinin receptor, beta 1
Synonyms: kinin B1, B1R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12061
HGNC: HGNC:1029
Homologene: 570
Uchl1
Name: ubiquitin carboxy-terminal hydrolase L1
Synonyms: PGP9.5, PGP 9.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22223
Homologene: 37894
Il7r
Name: interleukin 7 receptor
Synonyms: IL-7 receptor alpha chain, CD127, IL-7Ralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16197
VEGA: 15
HGNC: HGNC:6024
Homologene: 1646
Slc20a2
Name: solute carrier family 20, member 2
Synonyms: MolPit2, PiT-2, Ram-1, Ram1, Pit-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20516
Homologene: 68531
Psmd2
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms: TEG-190, Tex190, 9430095H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 21762
HGNC: HGNC:9559
Homologene: 2101
Stra6
Name: stimulated by retinoic acid gene 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20897
Homologene: 7554
Epha5
Name: Eph receptor A5
Synonyms: Cek7, bsk, Els1, Rek7, Hek7, Ehk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 637515
Homologene: 19080
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78250
Homologene: 11258
Asns
Name: asparagine synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27053
HGNC: HGNC:753
Homologene: 69113
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51938
Homologene: 12149
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330723
Homologene: 17801
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Or2b4
Name: olfactory receptor family 2 subfamily B member 4
Synonyms: MOR256-3, GA_x6K02T2PSCP-2264806-2265753, A3, Olfr124, SR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 259064
Homologene: 74266
Tbc1d2b
Name: TBC1 domain family, member 2B
Synonyms: 1810061M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67016
Homologene: 56694
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74362
Homologene: 52601
Arhgap40
Name: Rho GTPase activating protein 40
Synonyms: Gm14203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545481
Homologene: 53500
Sart1
Name: squamous cell carcinoma antigen recognized by T cells 1
Synonyms: U5-110K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20227
VEGA: 19
Homologene: 133770
Dhx34
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 34
Synonyms: 1810012L18Rik, Ddx34, 1200013B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71723
Homologene: 69171
Etnppl
Name: ethanolamine phosphate phospholyase
Synonyms: 1300019H02Rik, Agxt2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71760
Homologene: 69440
Gal3st1
Name: galactose-3-O-sulfotransferase 1
Synonyms: galactosylceramide sulfotransferase, 3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase, GalCer sulfotransferase, Gcst, Cst
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53897
Homologene: 3574
Ankrd6
Name: ankyrin repeat domain 6
Synonyms: diversin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140577
Homologene: 8967
CT030661.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Or10ak16
Name: olfactory receptor family 10 subfamily AK member 16
Synonyms: GA_x6K02T2QD9B-18644371-18643424, MOR259-8, Olfr1330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258331
Homologene: 121524
Or2y8
Name: olfactory receptor family 2 subfamily Y member 8
Synonyms: GA_x6K02T2QP88-3283154-3284089, MOR256-69_p, Olfr1373
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 211472
Homologene: 72463
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: THAM, Cd26, Dpp-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Smyd4
Name: SET and MYND domain containing 4
Synonyms: G430029E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319822
Homologene: 35098
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: 9330155G14Rik, WI-18508, Nope, WI-16786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Csnka2ip
Name: casein kinase 2, alpha prime interacting protein
Synonyms: Ckt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224291
Homologene: 77570
Bod1
Name: biorientation of chromosomes in cell division 1
Synonyms: 2310022M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69556
Homologene: 16300
Ifi214
Name: interferon activated gene 214
Synonyms: BC094916, Pyhin-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545384
Homologene: 115929
Gm9025
Name: predicted gene 9025
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 668181
Mettl17
Name: methyltransferase like 17
Synonyms: 2310032K15Rik, D14Ertd209e, Mett11d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 52535
Homologene: 11226
Gm11127
Name: predicted gene 11127
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100529082
Homologene: 133121
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 171,418,109 bp
  • A to T, chromosome 1 at 173,523,027 bp
  • C to T, chromosome 1 at 181,956,501 bp
  • A to T, chromosome 2 at 62,352,286 bp
  • A to G, chromosome 2 at 158,549,647 bp
  • T to C, chromosome 3 at 33,826,480 bp
  • C to T, chromosome 3 at 54,706,941 bp
  • A to G, chromosome 3 at 100,093,676 bp
  • A to T, chromosome 3 at 130,629,563 bp
  • A to T, chromosome 3 at 158,012,790 bp
  • T to C, chromosome 4 at 32,822,232 bp
  • T to C, chromosome 4 at 118,893,205 bp
  • T to A, chromosome 5 at 24,439,057 bp
  • G to T, chromosome 5 at 66,302,678 bp
  • T to A, chromosome 5 at 66,682,465 bp
  • G to T, chromosome 5 at 84,150,395 bp
  • C to T, chromosome 5 at 84,150,396 bp
  • G to A, chromosome 6 at 7,676,076 bp
  • G to C, chromosome 7 at 16,218,349 bp
  • A to G, chromosome 7 at 50,853,840 bp
  • A to T, chromosome 7 at 109,918,601 bp
  • A to G, chromosome 7 at 128,190,210 bp
  • T to C, chromosome 7 at 135,697,311 bp
  • A to G, chromosome 8 at 22,560,703 bp
  • T to C, chromosome 8 at 25,033,596 bp
  • A to T, chromosome 9 at 58,151,404 bp
  • A to T, chromosome 9 at 63,536,227 bp
  • A to G, chromosome 9 at 65,131,650 bp
  • G to A, chromosome 9 at 70,110,274 bp
  • G to A, chromosome 9 at 90,222,340 bp
  • A to G, chromosome 11 at 3,998,509 bp
  • T to C, chromosome 11 at 31,671,514 bp
  • T to A, chromosome 11 at 52,144,850 bp
  • C to G, chromosome 11 at 71,181,686 bp
  • T to C, chromosome 11 at 75,400,338 bp
  • G to A, chromosome 12 at 105,604,303 bp
  • T to C, chromosome 13 at 111,883,914 bp
  • A to G, chromosome 14 at 51,889,606 bp
  • A to G, chromosome 14 at 54,987,403 bp
  • A to C, chromosome 14 at 103,095,403 bp
  • T to C, chromosome 15 at 9,516,457 bp
  • T to C, chromosome 16 at 20,659,959 bp
  • G to T, chromosome 16 at 49,120,054 bp
  • T to A, chromosome 16 at 64,477,947 bp
  • T to A, chromosome 17 at 22,200,945 bp
  • C to T, chromosome 17 at 36,056,146 bp
  • T to A, chromosome 17 at 37,805,769 bp
  • A to G, chromosome 19 at 5,381,307 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1075 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039161-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.