Strain Name:
C57BL/6J-MtgxR1115Btlr/Mmmh
Stock Number:
039188-MU
Citation ID:
RRID:MMRRC_039188-MU
Other Names:
R1115 (G1), C57BL/6J-MtgxR1115Btlr
Major Collection:

Gene Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: Steel Factor Receptor, c-KIT, Dominant white spotting, belly-spot, Tr-kit, SOW3, SCO5, SCO1, Gsfsow3, Gsfsco5, Gsfsco1, CD117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Cd40
Name: CD40 antigen
Synonyms: Cd40, Bp50, p50, Tnfrsf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21939
Homologene: 954
Ift52
Name: intraflagellar transport 52
Synonyms: NGD5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 245866
Homologene: 9335
Nphs1
Name: nephrosis 1, nephrin
Synonyms: nephrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54631
HGNC: HGNC:7908
Homologene: 20974
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Fbxw8
Name: F-box and WD-40 domain protein 8
Synonyms: FBXO29, Fbx29, FBW8, FBW6, 4930438M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231672
Homologene: 17731
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2b, NZF-2a, Nzf2, Nztf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, eyes2, crf11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329872
Homologene: 27049
Arfgap3
Name: ADP-ribosylation factor GTPase activating protein 3
Synonyms: 1810004P07Rik, 1810035F16Rik, 0610009H19Rik, 9130416J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66251
VEGA: 15
HGNC: HGNC:661
Homologene: 134103
Mxra7
Name: matrix-remodelling associated 7
Synonyms: E130302J09Rik, 1810057P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67622
HGNC: HGNC:7541
Homologene: 137378
Znhit6
Name: zinc finger, HIT type 6
Synonyms: 2410019A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229937
Homologene: 32378
Osgin2
Name: oxidative stress induced growth inhibitor family member 2
Synonyms: C230027H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 209212
HGNC: HGNC:1355
Homologene: 3201
Slamf7
Name: SLAM family member 7
Synonyms: novel Ly9, 4930560D03Rik, 19A, 19A24, CS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75345
Homologene: 49660
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: dunce, Dpde4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: 9930021J17Rik, Fam160a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229488
Homologene: 85149
Efcab2
Name: EF-hand calcium binding domain 2
Synonyms: D830011E08Rik, 1700073K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68226
Homologene: 12248
Fastkd2
Name: FAST kinase domains 2
Synonyms: 2810421I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75619
Homologene: 8957
Ccr7
Name: chemokine (C-C motif) receptor 7
Synonyms: EBI1, Ebi1h, CD197, Cmkbr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12775
HGNC: HGNC:1608
Homologene: 1387
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242505
Homologene: 28424
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Stard9
Name: START domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap-1, Mtap1, 6330416M19Rik, Mtap1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Slco1b2
Name: solute carrier organic anion transporter family, member 1b2
Synonyms: mlst-1, Slc21a6, Slc21a10, Oatp1b2, 7330442B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28253
Homologene: 75119
Olfr63
Name: olfactory receptor 63
Synonyms: M4, MOR267-1, GA_x6K02T2NTC5-9778-8828
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258939
HGNC: HGNC:8174
Homologene: 130665
Sdcbp
Name: syndecan binding protein
Synonyms: syntenin, syndecan interacting protein, Sycl, MDA-9, syntenin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 53378
Homologene: 4110
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Ren1
Name: renin 1 structural
Synonyms: Ren1d, Ren-A, Rn-1, Ren, Rnr, Ren-1, Ren1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19701
HGNC: HGNC:9958
Homologene: 20151
Coro2b
Name: coronin, actin binding protein, 2B
Synonyms: E130012P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235431
HGNC: HGNC:2256
Homologene: 21228
Olfr355
Name: olfactory receptor 355
Synonyms: GA_x6K02T2NLDC-33622642-33621710, MOR138-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258618
Homologene: 132326
S100a8
Name: S100 calcium binding protein A8 (calgranulin A)
Synonyms: MRP8, Caga, 60B8Ag, CFAg, CP-10, B8Ag, p8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20201
Homologene: 2225
Bcl2l14
Name: BCL2-like 14 (apoptosis facilitator)
Synonyms: 4933405K19Rik, 9030625M01Rik, 4930452K23Rik, Bcl-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66813
Homologene: 49840
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 54,417,778 bp
  • T to C, chromosome 1 at 63,747,955 bp
  • G to A, chromosome 1 at 93,281,654 bp
  • T to A, chromosome 1 at 133,356,518 bp
  • A to T, chromosome 1 at 171,639,183 bp
  • A to T, chromosome 1 at 178,437,497 bp
  • C to A, chromosome 2 at 36,927,502 bp
  • T to C, chromosome 2 at 120,692,850 bp
  • T to C, chromosome 2 at 121,307,378 bp
  • A to G, chromosome 2 at 163,029,782 bp
  • A to G, chromosome 2 at 165,070,761 bp
  • C to A, chromosome 2 at 181,811,231 bp
  • T to C, chromosome 3 at 85,722,495 bp
  • A to G, chromosome 3 at 90,669,873 bp
  • G to T, chromosome 3 at 145,594,685 bp
  • G to A, chromosome 4 at 6,377,143 bp
  • A to T, chromosome 4 at 15,998,085 bp
  • G to T, chromosome 4 at 73,748,604 bp
  • T to C, chromosome 4 at 83,020,770 bp
  • T to A, chromosome 4 at 102,542,155 bp
  • T to C, chromosome 5 at 75,649,532 bp
  • A to C, chromosome 5 at 118,077,571 bp
  • T to A, chromosome 6 at 125,655,065 bp
  • T to C, chromosome 6 at 134,432,139 bp
  • A to G, chromosome 6 at 141,683,254 bp
  • C to T, chromosome 7 at 30,481,378 bp
  • A to C, chromosome 7 at 109,918,761 bp
  • T to G, chromosome 9 at 62,431,327 bp
  • T to C, chromosome 10 at 75,717,677 bp
  • A to T, chromosome 11 at 99,145,277 bp
  • C to A, chromosome 11 at 100,479,255 bp
  • C to T, chromosome 11 at 113,838,646 bp
  • G to T, chromosome 11 at 116,810,870 bp
  • T to C, chromosome 15 at 83,330,540 bp
  • C to T, chromosome 17 at 33,268,966 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1115 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039188-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.