Strain Name:
C57BL/6J-MtgxR1125Btlr/Mmmh
Stock Number:
039198-MU
Citation ID:
RRID:MMRRC_039198-MU
Other Names:
R1125 (G1), C57BL/6J-MtgxR1125Btlr
Major Collection:

Gene Information

Gid4
Name: GID complex subunit 4, VID24 homolog
Synonyms: 4933439F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66771
Homologene: 5971
Lrrc41
Name: leucine rich repeat containing 41
Synonyms: MUF1, D630045E04Rik, D730026A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230654
Homologene: 4645
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Ttc5
Name: tetratricopeptide repeat domain 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219022
VEGA: 14
Homologene: 14397
Smc3
Name: structural maintenance of chromosomes 3
Synonyms: Mmip1, Bamacan, Cspg6, SmcD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13006
HGNC: HGNC:2468
Homologene: 3974
Nckap1
Name: NCK-associated protein 1
Synonyms: mh19, Hem2, Hem-2, H19, Nap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Uhrf1bp1
Name: UHRF1 (ICBP90) binding protein 1
Synonyms: F830021D11Rik, 1110020K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224648
Homologene: 9816
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: 1810010K08Rik, Zntl1, Znt5, ZnT-5, ZTL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69048
VEGA: 13
Homologene: 41503
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231128
Homologene: 2746
C87436
Name: expressed sequence C87436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232196
Homologene: 9897
Ppara
Name: peroxisome proliferator activated receptor alpha
Synonyms: PPAR-alpha, Ppar, PPARalpha, Nr1c1, 4933429D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19013
HGNC: HGNC:9232
Homologene: 21047
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: Factor XIIIA, 1200014I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Necab1
Name: N-terminal EF-hand calcium binding protein 1
Synonyms: 1700003H21Rik, STIP-1, Efcbp1, NECAB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69352
Homologene: 11172
Ctns
Name: cystinosis, nephropathic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83429
HGNC: HGNC:2518
Homologene: 3625
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665227
Homologene: 129751
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20649
Homologene: 9618
Sytl2
Name: synaptotagmin-like 2
Synonyms: Slp2-c, Slp2, Slp2-a, Slp2-b, Slp2-d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83671
Homologene: 131343
Cd226
Name: CD226 antigen
Synonyms: Pta1, DNAM1, DNAM-1, TLiSA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225825
Homologene: 4787
Olfr693
Name: olfactory receptor 693
Synonyms: MOR283-8, GA_x6K02T2PBJ9-9055944-9054994
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258445
A1cf
Name: APOBEC1 complementation factor
Synonyms: 1810073H04Rik, apobec-1 complementation factor, ACF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69865
VEGA: 19
Homologene: 16363
Oosp1
Name: oocyte secreted protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 170834
Homologene: 87189
Cbs
Name: cystathionine beta-synthase
Synonyms: HIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12411
Homologene: 37258
Ttll10
Name: tubulin tyrosine ligase-like family, member 10
Synonyms: 4930595O22Rik, 4833412E22Rik, Ttll5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 330010
Homologene: 51912
Plekhd1
Name: pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
Synonyms: 3830431G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217682
Homologene: 15090
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Anks4b
Name: ankyrin repeat and sterile alpha motif domain containing 4B
Synonyms: Harp, 2010013E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72074
Homologene: 49898
Lrrc23
Name: leucine rich repeat containing 23
Synonyms: 4921537K05Rik, Lrpb7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16977
Homologene: 5082
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53791
Homologene: 20698
Glra3
Name: glycine receptor, alpha 3 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 110304
HGNC: HGNC:4328
Homologene: 142
Fam166b
Name: family with sequence similarity 166, member B
Synonyms: 4833436C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329831
Homologene: 52229
Cav3
Name: caveolin 3
Synonyms: M-caveolin, Cav-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12391
HGNC: HGNC:1529
Homologene: 7255
AC147801.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Slc29a2
Name: solute carrier family 29 (nucleoside transporters), member 2
Synonyms: HNP36, ENT2, Der12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13340
VEGA: 19
Homologene: 37493
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 182,973,892 bp
  • C to T, chromosome 2 at 80,517,942 bp
  • A to T, chromosome 3 at 55,857,006 bp
  • T to A, chromosome 4 at 15,111,257 bp
  • A to G, chromosome 4 at 43,427,550 bp
  • A to T, chromosome 4 at 116,096,312 bp
  • A to G, chromosome 4 at 156,035,038 bp
  • T to A, chromosome 5 at 34,458,986 bp
  • T to C, chromosome 6 at 86,447,362 bp
  • T to A, chromosome 6 at 112,472,296 bp
  • A to G, chromosome 6 at 124,776,182 bp
  • G to A, chromosome 7 at 8,485,543 bp
  • A to T, chromosome 7 at 38,906,983 bp
  • T to A, chromosome 7 at 90,383,080 bp
  • T to A, chromosome 7 at 106,678,007 bp
  • T to G, chromosome 7 at 120,182,357 bp
  • A to G, chromosome 8 at 56,039,754 bp
  • A to G, chromosome 11 at 60,424,781 bp
  • C to A, chromosome 11 at 73,187,837 bp
  • C to A, chromosome 12 at 80,707,224 bp
  • T to C, chromosome 12 at 118,911,547 bp
  • T to A, chromosome 13 at 36,943,881 bp
  • C to T, chromosome 13 at 100,803,413 bp
  • A to G, chromosome 14 at 50,777,878 bp
  • T to G, chromosome 15 at 55,749,280 bp
  • A to G, chromosome 15 at 85,789,055 bp
  • T to C, chromosome 17 at 18,257,455 bp
  • T to C, chromosome 17 at 27,893,449 bp
  • A to T, chromosome 17 at 31,632,831 bp
  • A to G, chromosome 18 at 89,267,922 bp
  • G to T, chromosome 19 at 5,024,602 bp
  • C to A, chromosome 19 at 11,687,328 bp
  • T to C, chromosome 19 at 31,920,978 bp
  • T to A, chromosome 19 at 53,623,043 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1125 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039198-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.