Strain Name:
C57BL/6J-MtgxR1130Btlr/Mmmh
Stock Number:
039203-MU
Citation ID:
RRID:MMRRC_039203-MU
Other Names:
R1130 (G1), C57BL/6J-MtgxR1130Btlr
Major Collection:

Strain Information

Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Tac2
Name: tachykinin 2
Synonyms: neuropeptide K, neuromedin L, neurokinin alpha, neurokinin 2, neurokinin A, substance K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21334
VEGA: 10
Homologene: 7560
Ociad1
Name: OCIA domain containing 1
Synonyms: expressed during mesenchymal induction 2, Emi2, B230209J16Rik, 6030432N09Rik, TPA018, Asrij, Imi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68095
Homologene: 9866
Aurka
Name: aurora kinase A
Synonyms: Ayk1, Ark1, IAK, AIRK1, aurora A, Aurora-A, Stk6, IAK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20878
Homologene: 2670
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, Aspm, D330028K02Rik, MCPH5, Calmbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12316
Homologene: 7650
Ptprj
Name: protein tyrosine phosphatase, receptor type, J
Synonyms: Byp, DEP-1, Scc-1, Scc1, CD148, RPTPJ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, crf11, eyes2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329872
Homologene: 27049
Nrde2
Name: nrde-2 necessary for RNA interference, domain containing
Synonyms: 6720454P05Rik, BC002230
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217827
VEGA: 12
Homologene: 41213
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Gml2
Name: glycosylphosphatidylinositol anchored molecule like 2
Synonyms: HemT, hematopoietic cell-specific transcript, 1700057K19Rik, Hemt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15202
HGNC: HGNC:4375
Homologene: 48071
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: merg1a, ether a go-go related, M-erg, LQT, Lqt2, ERG1, merg1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Stk-ps2
Name: serine/threonine kinase 2
Synonyms: Gm4776
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 212225
Fbxw24
Name: F-box and WD-40 domain protein 24
Synonyms: Gm5162
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382106
Homologene: 110776
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213402
Homologene: 41848
H1f6
Name: H1.6 linker histone, cluster member
Synonyms: H1ft, H1t, Hist1h1t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107970
HGNC: HGNC:4720
Homologene: 3889
Cfap45
Name: cilia and flagella associated protein 45
Synonyms: 1700028D05Rik, Nesg1, Ccdc19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71870
Homologene: 71837
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 328505
Homologene: 106613
Defb19
Name: defensin beta 19
Synonyms: Tdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 246700
Homologene: 17045
Rxylt1
Name: ribitol xylosyltransferase 1
Synonyms: 6330415D21Rik, Tmem5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216395
Homologene: 8600
Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
Synonyms: IAP, Akp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11648
HGNC: HGNC:437
Homologene: 134333
Srsf2
Name: serine and arginine-rich splicing factor 2
Synonyms: MRF-1, D11Wsu175e, SC35, Sfrs10, Sfrs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20382
Homologene: 37721
Tex50
Name: testis expressed 50
Synonyms: 4930469G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100502590
Homologene: 130370
Gm9945
Name: predicted gene 9945
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Cldn20
Name: claudin 20
Synonyms: EG621628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 621628
VEGA: 17
HGNC: HGNC:2042
Homologene: 47972
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,029,336 bp
  • G to A, chromosome 1 at 87,127,871 bp
  • A to T, chromosome 1 at 139,477,834 bp
  • A to G, chromosome 1 at 161,157,352 bp
  • T to C, chromosome 1 at 172,545,697 bp
  • A to G, chromosome 2 at 90,453,421 bp
  • C to A, chromosome 2 at 152,576,189 bp
  • A to T, chromosome 2 at 172,357,258 bp
  • T to G, chromosome 4 at 82,916,628 bp
  • T to C, chromosome 4 at 111,984,158 bp
  • G to A, chromosome 5 at 24,331,825 bp
  • T to C, chromosome 5 at 73,294,332 bp
  • A to T, chromosome 9 at 109,608,202 bp
  • T to C, chromosome 10 at 42,011,834 bp
  • T to C, chromosome 10 at 122,095,942 bp
  • A to G, chromosome 10 at 127,729,502 bp
  • T to A, chromosome 11 at 53,480,518 bp
  • A to G, chromosome 11 at 116,852,183 bp
  • C to T, chromosome 11 at 119,274,683 bp
  • A to T, chromosome 12 at 100,125,670 bp
  • G to T, chromosome 13 at 23,696,324 bp
  • A to T, chromosome 13 at 98,748,289 bp
  • G to A, chromosome 15 at 74,821,346 bp
  • C to T, chromosome 15 at 82,059,360 bp
  • T to C, chromosome 17 at 3,532,968 bp
  • T to C, chromosome 18 at 57,262,006 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1130 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039203-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.