Strain Name:
C57BL/6J-MtgxR1133Btlr/Mmmh
Stock Number:
039206-MU
Citation ID:
RRID:MMRRC_039206-MU
Other Names:
R1133 (G1), C57BL/6J-MtgxR1133Btlr
Major Collection:

Gene Information

Ccar2
Name: cell cycle activator and apoptosis regulator 2
Synonyms: 2610301G19Rik, Dbc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219158
VEGA: 14
Homologene: 10910
AC159748.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Ttc30a2
Name: tetratricopeptide repeat domain 30A2
Synonyms: OTTMUSG00000015167
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 620631
Homologene: 44342
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100559
Homologene: 137225
Socs4
Name: suppressor of cytokine signaling 4
Synonyms: A730004F22Rik, Socs7, 3110032M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67296
Homologene: 15442
Hook2
Name: hook microtubule tethering protein 2
Synonyms: A630054I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170833
Homologene: 8332
B430305J03Rik
Name: RIKEN cDNA B430305J03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Mmp25
Name: matrix metallopeptidase 25
Synonyms: MT6-MMP, Leukolysin, F730048C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240047
VEGA: 17
Homologene: 23375
Ahr
Name: aryl-hydrocarbon receptor
Synonyms: In, dioxin receptor, bHLHe76, Ah, Ahh, Ahre
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11622
HGNC: HGNC:348
Homologene: 1224
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Olfr147
Name: olfactory receptor 147
Synonyms: MOR164-1, GA_x6K02T2PVTD-32098059-32099003, M3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258869
VEGA: 9
Homologene: 128279
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 2 at 75,977,383 bp
  • C to T, chromosome 3 at 61,364,009 bp
  • T to G, chromosome 5 at 87,412,373 bp
  • T to C, chromosome 8 at 84,995,804 bp
  • A to T, chromosome 9 at 38,403,731 bp
  • A to G, chromosome 10 at 5,349,044 bp
  • A to G, chromosome 12 at 35,526,806 bp
  • A to G, chromosome 14 at 47,290,194 bp
  • A to G, chromosome 14 at 70,139,754 bp
  • T to A, chromosome 16 at 38,005,321 bp
  • T to A, chromosome 17 at 23,644,185 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1133 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039206-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.