Strain Name:
C57BL/6J-MtgxR1136Btlr/Mmmh
Stock Number:
039209-MU
Citation ID:
RRID:MMRRC_039209-MU
Other Names:
R1136 (G1), C57BL/6J-MtgxR1136Btlr
Major Collection:

Gene Information

Matr3
Name: matrin 3
Synonyms: 1110061A14Rik, 2810017I02Rik, D030046F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17184
HGNC: HGNC:6912
Homologene: 7830
Plekhj1
Name: pleckstrin homology domain containing, family J member 1
Synonyms: 9530063M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 78670
VEGA: 10
Homologene: 11389
Pex7
Name: peroxisomal biogenesis factor 7
Synonyms: peroxisome biogenesis factor 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18634
HGNC: HGNC:8860
Homologene: 242
Nudt3
Name: nudix (nucleotide diphosphate linked moiety X)-type motif 3
Synonyms: diphosphoinositol polyphosphate phosphohydrolase, 1110011B09Rik, Dipp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56409
HGNC: HGNC:8050
Homologene: 31400
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, b2b3190Clo, Dock180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Dgkh
Name: diacylglycerol kinase, eta
Synonyms: 5930402B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380921
VEGA: 14
HGNC: HGNC:2854
Homologene: 99373
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230393
Homologene: 9842
Eef2
Name: eukaryotic translation elongation factor 2
Synonyms: Ef-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13629
VEGA: 10
HGNC: HGNC:3214
Homologene: 134867
Akap8l
Name: A kinase (PRKA) anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: Nirf, D130071B19Rik, 2310065A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109113
Homologene: 17001
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 4930596K11Rik, 6330407G04Rik, CHMP family, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105513
VEGA: 14
Homologene: 14613
Sucla2
Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms: 4930547K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20916
Homologene: 2856
N4bp2
Name: NEDD4 binding protein 2
Synonyms: LOC386488, B3bp, LOC333789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333789
Homologene: 32396
Phyhipl
Name: phytanoyl-CoA hydroxylase interacting protein-like
Synonyms: 4921522K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70911
Homologene: 13028
Gpbp1l1
Name: GC-rich promoter binding protein 1-like 1
Synonyms: 5330440M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77110
Homologene: 84840
Bmp2
Name: bone morphogenetic protein 2
Synonyms: Bmp2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12156
HGNC: HGNC:1069
Homologene: 926
Mtch1
Name: mitochondrial carrier 1
Synonyms: 2310034O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56462
Homologene: 22807
Tmtc3
Name: transmembrane and tetratricopeptide repeat containing 3
Synonyms: 9130014E20Rik, B130008E12Rik, mSmile
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237500
Homologene: 27616
Tent2
Name: terminal nucleotidyltransferase 2
Synonyms: 8030446C20Rik, Papd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100715
VEGA: 13
Homologene: 44022
Zfp457
Name: zinc finger protein 457
Synonyms: Rslcan-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 431706
Homologene: 75311
C1qtnf3
Name: C1q and tumor necrosis factor related protein 3
Synonyms: Corcs, CTRP3, 2310005P21Rik, CORS-26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 81799
Homologene: 12788
Hnrnpu
Name: heterogeneous nuclear ribonucleoprotein U
Synonyms: Hnrpu, Sp120, scaffold attachment factor A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 51810
HGNC: HGNC:5048
Homologene: 22991
Mfsd14b
Name: major facilitator superfamily domain containing 14B
Synonyms: 5730414C17Rik, Hiatl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66631
Homologene: 64464
Nmd3
Name: NMD3 ribosome export adaptor
Synonyms: C87860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 97112
Homologene: 6127
Sec63
Name: SEC63-like (S. cerevisiae)
Synonyms: 5730478J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 140740
Homologene: 5220
Wdcp
Name: WD repeat and coiled coil containing
Synonyms: BC068281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238037
VEGA: 12
Homologene: 49822
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70129
Homologene: 11359
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Wdr93
Name: WD repeat domain 93
Synonyms: EG626359
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 626359
Homologene: 56878
Gm4847
Name: predicted gene 4847
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226604
Homologene: 101040
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319555
Homologene: 72261
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: A430075I06Rik, E430002F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231050
Homologene: 11126
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: E230008N13Rik, LOC381522
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381522
Homologene: 117988
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, Mll4, C430014K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Mylk
Name: myosin, light polypeptide kinase
Synonyms: MLCK108, nmMlck, MLCK210, Mlck, 9530072E15Rik, telokin, A930019C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Esp6
Name: exocrine gland secreted peptide 6
Synonyms: Esp5, Gm5494
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 433107
VEGA: 17
Ercc6l2
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
Synonyms: 0610007P08Rik, 9330134C04Rik, 1700019D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76251
Homologene: 32564
Foxred1
Name: FAD-dependent oxidoreductase domain containing 1
Synonyms: TEG-23, Tex23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235169
Homologene: 9712
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620697
Homologene: 115466
Samsn1
Name: SAM domain, SH3 domain and nuclear localization signals, 1
Synonyms: Hacs1, 4930571B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67742
Homologene: 11148
Ncf2
Name: neutrophil cytosolic factor 2
Synonyms: Ncf-2, p67phox, NADPH oxidase subunit (67kDa), NOXA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17970
HGNC: HGNC:7661
Homologene: 374
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Tedc2
Name: tubulin epsilon and delta complex 2
Synonyms: 1600002H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72016
Homologene: 45943
Trafd1
Name: TRAF type zinc finger domain containing 1
Synonyms: 1110008K06Rik, Fln29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231712
Homologene: 31399
Prss21
Name: protease, serine 21
Synonyms: 1700023E12Rik, testisin, mT4, TESP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57256
HGNC: HGNC:9485
Homologene: 137342
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 20,522,829 bp
  • A to T, chromosome 1 at 152,830,372 bp
  • A to G, chromosome 1 at 166,630,366 bp
  • A to T, chromosome 1 at 178,331,225 bp
  • G to T, chromosome 2 at 25,407,715 bp
  • T to C, chromosome 2 at 133,560,927 bp
  • T to A, chromosome 3 at 69,746,716 bp
  • C to A, chromosome 4 at 45,914,589 bp
  • T to C, chromosome 4 at 88,326,180 bp
  • C to T, chromosome 4 at 116,592,918 bp
  • T to G, chromosome 5 at 25,258,945 bp
  • T to C, chromosome 5 at 65,808,472 bp
  • C to T, chromosome 5 at 121,373,324 bp
  • T to C, chromosome 7 at 79,773,448 bp
  • T to A, chromosome 7 at 85,222,341 bp
  • T to A, chromosome 7 at 134,848,173 bp
  • G to T, chromosome 7 at 141,638,772 bp
  • C to T, chromosome 8 at 72,697,769 bp
  • C to A, chromosome 9 at 35,205,037 bp
  • T to A, chromosome 10 at 19,888,688 bp
  • A to T, chromosome 10 at 42,806,546 bp
  • A to G, chromosome 10 at 70,569,072 bp
  • A to T, chromosome 10 at 80,797,820 bp
  • C to CN, chromosome 10 at 81,178,769 bp
  • A to G, chromosome 10 at 100,472,043 bp
  • G to A, chromosome 12 at 4,851,655 bp
  • T to A, chromosome 13 at 63,869,120 bp
  • C to T, chromosome 13 at 65,095,692 bp
  • T to C, chromosome 13 at 67,293,782 bp
  • C to T, chromosome 13 at 68,730,317 bp
  • C to T, chromosome 13 at 93,175,697 bp
  • C to T, chromosome 14 at 69,719,450 bp
  • C to T, chromosome 14 at 73,560,634 bp
  • T to C, chromosome 14 at 78,624,889 bp
  • A to G, chromosome 15 at 10,978,584 bp
  • A to T, chromosome 15 at 47,675,817 bp
  • A to T, chromosome 15 at 98,857,765 bp
  • T to C, chromosome 16 at 35,000,318 bp
  • T to C, chromosome 16 at 75,873,520 bp
  • T to A, chromosome 17 at 23,872,994 bp
  • T to A, chromosome 17 at 24,216,317 bp
  • C to A, chromosome 17 at 24,216,318 bp
  • C to A, chromosome 17 at 27,623,106 bp
  • C to T, chromosome 17 at 29,333,770 bp
  • C to T, chromosome 17 at 32,332,483 bp
  • C to T, chromosome 17 at 34,928,022 bp
  • T to C, chromosome 17 at 40,565,393 bp
  • A to G, chromosome 18 at 35,572,895 bp
  • T to A, chromosome 19 at 30,056,226 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1136 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039209-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.