Strain Name:
C57BL/6J-MtgxR1193Btlr/Mmmh
Stock Number:
039265-MU
Citation ID:
RRID:MMRRC_039265-MU
Other Names:
R1193 (G1), C57BL/6J-MtgxR1193Btlr
Major Collection:

Gene Information

Sp4
Name: trans-acting transcription factor 4
Synonyms: HF1-b, 5730497N03Rik, HF-1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20688
VEGA: 12
Homologene: 2341
Gpm6a
Name: glycoprotein m6a
Synonyms: Gpm6, M6A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234267
HGNC: HGNC:4460
Homologene: 3864
Top1
Name: topoisomerase (DNA) I
Synonyms: D130064I21Rik, Top-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21969
Homologene: 2467
Nudt5
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 53893
HGNC: HGNC:8052
Homologene: 5388
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: 9030416H16Rik, E230024D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71521
Homologene: 22877
Wwox
Name: WW domain-containing oxidoreductase
Synonyms: 5330426P09Rik, 9030416C10Rik, WOX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 80707
Homologene: 56334
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: D3Bwg1534e, 2610040L17Rik, Ten-m2, Odz2, 9330187F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 23964
Homologene: 22672
Rars
Name: arginyl-tRNA synthetase
Synonyms: 2610011N19Rik, 2610037E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 104458
HGNC: HGNC:9870
Homologene: 68281
Actl6a
Name: actin-like 6A
Synonyms: ARP4, 2810432C06Rik, Baf53a, Actl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56456
Homologene: 55811
Nupl1
Name: nucleoporin like 1
Synonyms: 1700017F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 71844
VEGA: 14
Homologene: 40924
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: Nrbp, B230344L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: Dna2l, E130315B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Shf
Name: Src homology 2 domain containing F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 435684
Homologene: 44524
Tcaim
Name: T cell activation inhibitor, mitochondrial
Synonyms: D9Ertd402e, LOC382117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382117
Homologene: 45481
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 624845
HGNC: null
Homologene: 83483
Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms: p110alpha, 6330412C24Rik, caPI3K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18706
HGNC: HGNC:8975
Homologene: 21249
Cenpt
Name: centromere protein T
Synonyms: G630055P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 320394
Homologene: 41610
Twnk
Name: twinkle mtDNA helicase
Synonyms: twinkle, D19Ertd626e, Peo1, Twinl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226153
VEGA: 19
HGNC: HGNC:1160
Homologene: 11052
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 52372
HGNC: null
Homologene: null
Tmem150c
Name: transmembrane protein 150C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231503
Homologene: 18818
Olfr1431
Name: olfactory receptor 1431
Synonyms: MOR214-5, GA_x6K02T2RE5P-2573738-2574676
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258409
HGNC: null
Homologene: 115495
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 620672
HGNC: null
Homologene: 115466
Olfr1336
Name: olfactory receptor 1336
Synonyms: MOR103-7, GA_x6K02T2QGBW-3190370-3191314
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258917
HGNC: null
Homologene: 37007
Rfk
Name: riboflavin kinase
Synonyms: 0610038L10Rik, ATP:riboflavin 5'-phosphotransferase, flavokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 54391
Homologene: 115690
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 2 at 5,863,600 bp
  • G to A, chromosome 2 at 122,368,682 bp
  • T to G, chromosome 2 at 160,670,210 bp
  • A to G, chromosome 3 at 32,456,093 bp
  • A to G, chromosome 3 at 32,712,144 bp
  • T to A, chromosome 5 at 31,245,813 bp
  • G to T, chromosome 5 at 65,637,802 bp
  • T to C, chromosome 5 at 100,083,592 bp
  • C to G, chromosome 6 at 87,111,524 bp
  • A to G, chromosome 7 at 6,460,716 bp
  • T to C, chromosome 7 at 85,151,445 bp
  • A to T, chromosome 8 at 55,047,233 bp
  • A to G, chromosome 8 at 105,847,185 bp
  • G to A, chromosome 8 at 114,679,874 bp
  • T to C, chromosome 9 at 122,818,830 bp
  • C to T, chromosome 10 at 62,949,187 bp
  • T to A, chromosome 10 at 79,377,905 bp
  • C to T, chromosome 11 at 35,809,326 bp
  • C to T, chromosome 11 at 36,063,177 bp
  • C to T, chromosome 12 at 118,299,246 bp
  • A to T, chromosome 14 at 60,244,670 bp
  • A to T, chromosome 19 at 12,210,439 bp
  • C to T, chromosome 19 at 17,395,321 bp
  • A to G, chromosome 19 at 45,007,790 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1193 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039265-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.