Strain Name:
C57BL/6J-MtgxR1202Btlr/Mmmh
Stock Number:
039272-MU
Citation ID:
RRID:MMRRC_039272-MU
Other Names:
R1202 (G1), C57BL/6J-MtgxR1202Btlr
Major Collection:

Gene Information

Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20269
Homologene: 56005
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217342
Homologene: 11113
Fmn2
Name: formin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54418
Homologene: 137334
Larp4b
Name: La ribonucleoprotein domain family, member 4B
Synonyms: D13Wsu64e, Larp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 217980
Homologene: 18195
Cct3
Name: chaperonin containing Tcp1, subunit 3 (gamma)
Synonyms: TriC-P5, Cctg, Tcp1-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12462
HGNC: HGNC:1616
Homologene: 4373
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Impdh2
Name: inosine monophosphate dehydrogenase 2
Synonyms: IMP dehydrogenase type II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23918
HGNC: HGNC:6053
Homologene: 48919
Pacs1
Name: phosphofurin acidic cluster sorting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107975
VEGA: 19
Homologene: 9970
9430015G10Rik
Name: RIKEN cDNA 9430015G10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230996
Homologene: 51678
Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Synonyms: methionine synthase, MS, D830038K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238505
VEGA: 13
HGNC: HGNC:7468
Homologene: 37280
Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Synonyms: PERK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13666
HGNC: HGNC:3255
Homologene: 3557
Gle1
Name: GLE1 RNA export mediator (yeast)
Synonyms: 4933405K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74412
HGNC: HGNC:4315
Homologene: 20379
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329002
Homologene: 7198
N4bp1
Name: NEDD4 binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80750
Homologene: 23703
Mycbpap
Name: MYCBP associated protein
Synonyms: AMAP-1, 4932408B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104601
Homologene: 49982
Fermt3
Name: fermitin family member 3
Synonyms: C79673, Kindlin-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 108101
VEGA: 19
Homologene: 12877
Tmem209
Name: transmembrane protein 209
Synonyms: 2700094F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72649
Homologene: 18021
Aadacl4fm1
Name: AADACL4 family member 1
Synonyms: LOC381572, 9430007A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381572
Homologene: 28662
Acsm1
Name: acyl-CoA synthetase medium-chain family member 1
Synonyms: Macs, Bucs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 117147
Homologene: 24930
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209590
Homologene: 16930
St8sia2
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Synonyms: ST8SiaII, Siat8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20450
Homologene: 4384
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546980
Homologene: 115466
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 260305
Homologene: 9024
Pabpc1l
Name: poly(A) binding protein, cytoplasmic 1-like
Synonyms: ePAB, 1810053B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381404
Homologene: 77989
Usp17lb
Name: ubiquitin specific peptidase 17-like B
Synonyms: Dub1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381944
Homologene: 131315
Sema4g
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26456
Homologene: 22682
Fndc5
Name: fibronectin type III domain containing 5
Synonyms: PeP, 1500001L03Rik, Pxp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 384061
Homologene: 17812
Hoxd11
Name: homeobox D11
Synonyms: Hox-5.4, Hox-4.6, E230017H14Rik, Hox-5.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15431
HGNC: HGNC:5134
Homologene: 7368
Tmprss11a
Name: transmembrane protease, serine 11a
Synonyms: LOC194597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 194597
Homologene: 62723
Slc26a10
Name: solute carrier family 26, member 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216441
VEGA: 10
Homologene: 66953
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 174,612,535 bp
  • C to T, chromosome 2 at 29,949,265 bp
  • T to C, chromosome 2 at 65,506,147 bp
  • C to T, chromosome 2 at 74,682,577 bp
  • G to T, chromosome 2 at 164,037,171 bp
  • T to C, chromosome 3 at 88,318,528 bp
  • G to A, chromosome 4 at 129,139,445 bp
  • T to C, chromosome 4 at 144,523,666 bp
  • G to A, chromosome 4 at 152,488,729 bp
  • A to G, chromosome 4 at 156,117,118 bp
  • T to A, chromosome 5 at 86,411,925 bp
  • C to G, chromosome 6 at 30,508,790 bp
  • A to G, chromosome 6 at 67,478,953 bp
  • T to C, chromosome 6 at 70,904,074 bp
  • A to T, chromosome 7 at 73,972,035 bp
  • G to A, chromosome 7 at 85,961,337 bp
  • G to A, chromosome 7 at 104,842,488 bp
  • A to G, chromosome 7 at 119,662,192 bp
  • T to C, chromosome 8 at 86,844,887 bp
  • T to C, chromosome 9 at 13,803,452 bp
  • G to A, chromosome 9 at 108,563,187 bp
  • A to G, chromosome 10 at 127,173,348 bp
  • T to C, chromosome 11 at 94,507,539 bp
  • C to T, chromosome 11 at 116,541,582 bp
  • A to G, chromosome 13 at 9,166,326 bp
  • A to G, chromosome 13 at 12,227,678 bp
  • A to T, chromosome 15 at 8,157,760 bp
  • T to A, chromosome 18 at 82,628,166 bp
  • G to A, chromosome 19 at 5,135,237 bp
  • A to G, chromosome 19 at 7,003,482 bp
  • G to T, chromosome 19 at 44,998,257 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1202 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039272-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.